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Referencia número: HY-164465

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C086

C086, a novel potent Hsp90 inhibitor, could inhibit cell cycle progression and induce cell apoptosis and anti-metastasis by regulating various mechanisms in different cell types.

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No. CAS: 1160107-44-7
Fòrmula: C₂₉H₂₈O₈
Peso molecular:504.53

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

C086 Chemical Structure

No. CAS: 1160107-44-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

C086, a novel potent Hsp90 inhibitor, could inhibit cell cycle progression and induce cell apoptosis and anti-metastasis by regulating various mechanisms in different cell types^[1].

Ver todos los productos específicos de isoformas HSP :

Cellular Effect

Cell Line	Type	Value	Description	References
Colon 26	IC₅₀	8.91 μM Compound: C086	Cytotoxicity against mouse Colon 26 cells after 4 hrs by MTT assay Cytotoxicity against mouse Colon 26 cells after 4 hrs by MTT assay	[PMID: 31336310]
HT-29	IC₅₀	5.42 μM Compound: C086	Cytotoxicity against human HT-29 cells after 4 hrs by MTT assay Cytotoxicity against human HT-29 cells after 4 hrs by MTT assay	[PMID: 31336310]
KM12	IC₅₀	3.9 μM Compound: C086	Cytotoxicity against human KM12 cells after 4 hrs by MTT assay Cytotoxicity against human KM12 cells after 4 hrs by MTT assay	[PMID: 31336310]
SW480	IC₅₀	4.78 μM Compound: C086	Cytotoxicity against human SW480 cells after 4 hrs by MTT assay Cytotoxicity against human SW480 cells after 4 hrs by MTT assay	[PMID: 31336310]
WiDr	IC₅₀	7.32 μM Compound: C086	Cytotoxicity against human WiDr cells after 4 hrs by MTT assay Cytotoxicity against human WiDr cells after 4 hrs by MTT assay	[PMID: 31336310]

In Vitro

C086 combined with Gefitinib damages the molecular chaperone functions of Hsp90 in NSCLC cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1160107-44-7
Peso molecular 504.53
Fòrmula C₂₉H₂₈O₈
SMILES

O=C(/C=C/C1=CC=C(O)C(OC)=C1)C(CC2=CC(OC)=C(O)C=C2)C(/C=C/C3=CC(OC)=C(O)C=C3)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Liman Wang, et al. Novel Hsp90 Inhibitor C086 Potently Inhibits Non-Small Cell Lung Cancer Cells As A Single Agent Or In Combination With Gefitinib. Cancer Manag Res. 2019 Oct 16:11:8937-8945. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

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Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- In Vitro
Chemical Information
Pureza y Documentación
Referencias

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C086

Ver todos los productos específicos de isoformas HSP