CHNQD-03005
CHNQD-03005 is an orally active anti-inflammatory agent. CHNQD-03005 inhibits the expression of iNOS and COX-2, reduces inflammatory signal transduction, suppresses NO production, and downregulates the pro-inflammatory cytokines TNF-α, IL-6 and IL-1β. CHNQD-03005 can be used in the research of inflammatory diseases such as colitis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C31H28O7
- Peso molecular:512.55
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
IL-6 |
COX-2 |
IL-1β |
In Vitro
CHNQD-03005 (Compound C13) (24 h) inhibits the production of TNF-α, IL-1β, IL-6 and NO in LPS (HY-D1056)-stimulated RAW264.7 cells, with IC50 values of 0.45 μM, 0.086 μM, 0.095 μM, and 0.038 μM, respectively[1].
CHNQD-03005 (0.2-6 μM) inhibits the protein expression of iNOS, COX-2 and IL-1β in LPS (HY-D1056)-stimulated RAW264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS (HY-D1056)-stimulated RAW264.7 cells
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Concentration:0.2, 2 and
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Incubation Time:6 μM
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Result:Inhibited the protein expression of iNOS, COX-2, and IL-1β in a concentration-dependent manner.
In Vivo
CHNQD-03005 (100 mg/kg; p.o.; single administration) exhibits favorable safety, with an oral MTD exceeding 100 mg/kg in male C57BL/6J mice[1].
CHNQD-03005 (20 mg/kg; p.o.; 21 days) is well tolerated in ICR mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 8 weeks old) treated DSS (HY-116282C)[1]
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Dosage:1 mg/kg
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Administration:p.o.; daily; 7-9 days
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Result:Significantly improved body weight loss, DAI scores, and colon length.
Preserved intestinal mucosal integrity, reduced crypt loss and inflammatory infiltration, and restored colonic architecture.
Reduced colon levels of TNF-α and IL-1β to control levels.
Chemical Information
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Peso molecular 512.55
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Fòrmula C31H28O7
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SMILES
C=CCOC1=CC=C(C=C1)C2=CC(OC)=C(C(OCC=C)=C2OC)C3=CC=C(C=C3)OC(C4=CC=CO4)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CHNQD-03005 Related Classifications
HY-181081 Related Classifications
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