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Referencia número: HY-183892

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d9A1-2

d9A1-2 is a potent SLC9A1 PROTAC degrader. d9A1-2 binds to SLC9A1 via the d9A1 warhead, recruits the CRL4CRBN E3 ubiquitin ligase through EBM, and thereby induces ubiquitination and proteasomal degradation of SLC9A1. d9A1-2 can be used for research on cancers such as acute myeloid leukemia.
(Pink: SLC9A1 Target protein ligand; Blue: Cereblon ligand (HY-10984); Black: linker (HY-22335)).

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2690350-15-1
Fòrmula: C₄₆H₅₄FN₇O₉
Peso molecular:867.96

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

d9A1-2 Chemical Structure

No. CAS: 2690350-15-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Bioz

Actividad biológica

Descripciòn

d9A1-2 is a potent SLC9A1 PROTAC degrader. d9A1-2 binds to SLC9A1 via the d9A1 warhead, recruits the CRL4CRBN E3 ubiquitin ligase through EBM, and thereby induces ubiquitination and proteasomal degradation of SLC9A1. d9A1-2 can be used for research on cancers such as acute myeloid leukemia^[1]. (Pink: SLC9A1 Target protein ligand; Blue: Cereblon ligand (HY-10984); Black: linker (HY-22335)).

IC₅₀ & Target^[1]

SLC9A1

Ver todos los productos específicos de isoformas PROTACs :

In Vitro

d9A1 (0.5-25 μM, 8-24 h) induces concentration-dependent degradation of endogenous SLC9A1 protein in HAP1 and KBM7 cells^[1].
d9A1-2 (1 μM; 16 h) exerts CRBN-dependent degradation of SLC9A1 in KBM7 WT and CRBN knockout cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HAP1 and KBM7 cells
Concentration:

0.25, 0.5, 1, 2.5 μM
Incubation Time:

8 h, 16 h
Result:

Successfully degraded various multi-pass transmembrane proteins located at the plasma membrane, lysosome, and endoplasmic reticulum in a time- and concentration-dependent manner.
Inhibited CRBN-dependent SLC9A1 degradation in KBM7 WT and CRBN knockout cells.

Chemical Information

No. CAS 2690350-15-1
Peso molecular 867.96
Fòrmula C₄₆H₅₄FN₇O₉
SMILES

O=C(C1=CC=C(C(N2CCC(CC2)C3=C(C)N=CN3)=C1)C4=CC(C)=C(F)C=C4)NCCOCCOCCOCCOCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Ariel Bensimon, et al. Compounds for targeted degradation of carrier proteins and uses thereof. EP3808741A1. EPO. 2021-04-21.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

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d9A1-2

Ver todos los productos específicos de isoformas PROTACs