Gü1303
Gü1303 is a potent, reversible, slow-binding cathepsin K (CatK) inhibitor with a Ki of 0.91 nM for mature CatK (mCatK). Gü1303 suppresses the autocatalytic activation of the cathepsin K zymogen.
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- No. CAS: 1043922-53-7
- Fòrmula: C20H22N4O3
- Peso molecular:366.41
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Ver todos los productos específicos de isoformas Cathepsin
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Actividad biológica
Ki: 0.91 nM (mCatK)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LLC-MK2 | CC50 |
42 μM
Compound: Neq0677
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Cytotoxicity against monkey LLC-MK2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against monkey LLC-MK2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 34095840] |
| U2OS | CC50 |
10.2 μM
Compound: Neq0677
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Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 34095840] |
Chemical Information
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No. CAS 1043922-53-7
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Peso molecular 366.41
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Fòrmula C20H22N4O3
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SMILES
CN(N(C([C@@H](NC(OCC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O)C)C#N
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Gü1303 Related Classifications
HY-144812 Related Classifications
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