G6374
G6374 is an IRE1 PROTAC degrader with a DC50 of 0.04 μM. G6374 induces efficient ubiquitination and degradation of IRE1. G6374 selectively inhibits IRE1-dependent cancer-cell proliferation.
(Pink: Ligands for Target Protein for PROTAC and IRE1 ligand (HY-180780); Blue: Ligands for E3 Ligase and VHL ligand (HY-125845); Black: linker (HY-W041652)).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C47H66N10O5S
- Peso molecular:883.16
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
DC50: 0.04 μM (IRE1)[1]
Chemical Information
-
Peso molecular 883.16
-
Fòrmula C47H66N10O5S
-
SMILES
CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCN4CCN(CC4)[C@H]5CC[C@@H](CC5)NC6=NC7=C(C=N6)C=CC(N7C(C)C)=O)=O)=O)O)=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
G6374 Related Classifications
HY-180787 Related Classifications
Powered by Bioz