Gedunin
Based on 1 Customer Validation
Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent Hsp90 inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.43%
- No. CAS: 2753-30-2
- Fòrmula: C28H34O7
- Peso molecular:482.57
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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HSP90 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>20 μM
Compound: 16
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Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay
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[PMID: 21381696] |
| AZ-521 cell line | IC50 |
16.9 μM
Compound: 16
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Cytotoxicity against human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay
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[PMID: 21381696] |
| HepG2 | IC50 |
>100 μM
Compound: 92124844
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HARVARD: Cytotoxicity in HepG2 cell line
HARVARD: Cytotoxicity in HepG2 cell line
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[PMID: 22586124] |
| HepG2 | IC50 |
0.76 μM
Compound: 92124844
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HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells
HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells
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[PMID: 22586124] |
| HL-60 | IC50 |
5.9 μM
Compound: 16
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Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by MTT assay
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[PMID: 21381696] |
| KB | IC50 |
2300 ng/mL
Compound: 1
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 9134742] |
| MCF7 | IC50 |
10.9 μM
Compound: 3
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Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS/PMS assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS/PMS assay
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[PMID: 25756299] |
| MCF7 | IC50 |
8.84 μM
Compound: 1
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Antiproliferative activity against human MCF7 cells after 72 hrs
Antiproliferative activity against human MCF7 cells after 72 hrs
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[PMID: 18816111] |
| P388 | IC50 |
3.3 μg/mL
Compound: 5
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Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
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[PMID: 16989525] |
| SH-SY5Y | EC50 |
38.95 nM
Compound: Gedunin
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Neuroprotection against beta-amyloid peptide 1-42-induced toxicity in human SH-SY5Y cells assessed as lactate dehydrogenase release
Neuroprotection against beta-amyloid peptide 1-42-induced toxicity in human SH-SY5Y cells assessed as lactate dehydrogenase release
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[PMID: 19138859] |
| SK-BR-3 | IC50 |
3.22 μM
Compound: 1
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Antiproliferative activity against human SKBr3 cells after 72 hrs
Antiproliferative activity against human SKBr3 cells after 72 hrs
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[PMID: 18816111] |
| SK-BR-3 | IC50 |
8.3 μM
Compound: 16
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Cytotoxicity against human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay
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[PMID: 21381696] |
Chemical Information
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No. CAS 2753-30-2
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Appearance Solid
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Peso molecular 482.57
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Fòrmula C28H34O7
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Color White to off-white
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SMILES
O=C1[C@](O2)([H])[C@@]32[C@](CC[C@]4([H])[C@@]5(C)C=CC(C(C)(C)[C@]5([H])C[C@@H](OC(C)=O)[C@]43C)=O)(C)[C@H](C6=COC=C6)O1
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 48.26 mg/mL (100.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (281 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Shaikh J Uddin, et al. Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytother Res. 2007 Aug;21(8):757-61. [Content Brief]
[2]. Gary E L Brandt, et al. Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships. J Med Chem. 2008 Oct 23;51(20):6495-502 [Content Brief]
[3]. Seshu Vardhan, et al. Virtual screening by targeting proteolytic sites of furin and TMPRSS2 to propose potential compounds obstructing the entry of SARS-CoV-2 virus into human host cells. J Tradit Complement Med. 2021 Apr 12. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0722 mL | 10.3612 mL | 20.7224 mL | 51.8060 mL |
| 5 mM | 0.4144 mL | 2.0722 mL | 4.1445 mL | 10.3612 mL | |
| 10 mM | 0.2072 mL | 1.0361 mL | 2.0722 mL | 5.1806 mL | |
| 15 mM | 0.1381 mL | 0.6907 mL | 1.3815 mL | 3.4537 mL | |
| 20 mM | 0.1036 mL | 0.5181 mL | 1.0361 mL | 2.5903 mL | |
| 25 mM | 0.0829 mL | 0.4144 mL | 0.8289 mL | 2.0722 mL | |
| 30 mM | 0.0691 mL | 0.3454 mL | 0.6907 mL | 1.7269 mL | |
| 40 mM | 0.0518 mL | 0.2590 mL | 0.5181 mL | 1.2951 mL | |
| 50 mM | 0.0414 mL | 0.2072 mL | 0.4144 mL | 1.0361 mL | |
| 60 mM | 0.0345 mL | 0.1727 mL | 0.3454 mL | 0.8634 mL | |
| 80 mM | 0.0259 mL | 0.1295 mL | 0.2590 mL | 0.6476 mL | |
| 100 mM | 0.0207 mL | 0.1036 mL | 0.2072 mL | 0.5181 mL |
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