BRDT - bromodomain testis associated Gene

Also Known as CT9; BRD6; SPGF21

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 676

About BRDT

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:91,949,371-92,014,428 (from NCBI)

This gene has 24 transcripts (splice variants), 148 orthologues, 11 paralogues and is associated with 1 phenotype. Restricted expression toward testis (RPKM 59.8).

Summary

BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

BRDT Products (16)

mRNA	Protein	Name
XM_047428955.1	XP_047284911.1	bromodomain testis-specific protein isoform X1
XM_006710855.5	XP_006710918.1	bromodomain testis-specific protein isoform X1
XM_047428967.1	XP_047284923.1	bromodomain testis-specific protein isoform X1
XM_011542035.4	XP_011540337.1	bromodomain testis-specific protein isoform X1
XM_011542034.4	XP_011540336.1	bromodomain testis-specific protein isoform X1
XM_011542032.4	XP_011540334.1	bromodomain testis-specific protein isoform X1
NM_001242805.2	NP_001229734.2	bromodomain testis-specific protein isoform b
NM_207189.4	NP_997072.2	bromodomain testis-specific protein isoform b
XM_011542036.4	XP_011540338.1	bromodomain testis-specific protein isoform X1
XM_006710856.5	XP_006710919.1	bromodomain testis-specific protein isoform X1
NM_001242807.2	NP_001229736.2	bromodomain testis-specific protein isoform c
XM_047428949.1	XP_047284905.1	bromodomain testis-specific protein isoform X1
NM_001726.4	NP_001717.3	bromodomain testis-specific protein isoform b
NM_001242806.2	NP_001229735.2	bromodomain testis-specific protein isoform a
NM_001242808.2	NP_001229737.2	bromodomain testis-specific protein isoform c
NM_001242810.2	NP_001229739.2	bromodomain testis-specific protein isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables histone binding	IDA IDA: Inferred from direct assay	22464331	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	28199965	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in nucleus	IDA IDA: Inferred from direct assay	25593309	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRDT Protein Structure

Bromodomain

0
200
400
600
800
947 a.a.

Protein Preferred Names	Protein Names
bromodomain testis-specific protein	RING3-like protein bromodomain, testis-specific cancer/testis antigen 9

Related Diseases

Diseases	Alias
Infertility
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Spermatogenic Failure 16	SPGF16 Acephalic Spermatozoa Syndrome Spermatozoa, Acephalic
Spermatogenic Failure 21	SPGF21
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Nut Midline Carcinoma	Nuclear Protein In Testis Midline Carcinoma Nmc
Male Infertility Due To Acephalic Spermatozoa	Acephalic Spermatozoa Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Referencia número	Nombre del producto	Efecto	Pureza	Phase
HY-112090	ABBV-744	Inhibitor	99.97%	Phase 1
HY-117286	(S)-JQ-35	Inhibitor	99.46%	Phase 1

Pre-clinical Phase

Bioactive Molecules (21)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-136570	GSK778	Inhibitor	99.14%	Unkown
HY-136571	GSK046	Inhibitor	99.70%	Unkown
HY-138563	GSK973	Inhibitor	99.97%	Unkown
HY-130622	LT052	Inhibitor	98.02%	Unkown
HY-114504	RVX-297	Inhibitor	95.00%	Unkown
HY-112610	CF53	Inhibitor	99.81%	Unkown
HY-131061	BET bromodomain inhibitor 1	Inhibitor	99.67%	Unkown
HY-160558	PLK1/BRD4-IN-3	Inhibitor	98.55%	Unkown
HY-126325	BY27	Inhibitor	/	Unkown
HY-155680	BET BD2-IN-1	Inhibitor	/	Unkown
HY-152213	BET-IN-13	Inhibitor	/	Unkown
HY-182371	BRD4 ligand 15	Ligand	/	Unkown
HY-150684	GXH-II-052	Inhibitor	/	Unkown
HY-149806	Bromodomain IN-2	Inhibitor	/	Unkown
HY-136794	SB-284851-BT	Inhibitor	/	Unkown
HY-183247	BRDT-IN-1	Inhibitor	/	Unkown
HY-150683	NC-III-49-1	Inhibitor	/	Unkown
HY-183248	BRDT-IN-2	Inhibitor	/	Unkown
HY-143471	WNY0824	Inhibitor	/	Unkown
HY-177140	CDD-1147	Inhibitor	/	Unkown
HY-136570A	GSK778 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	BRDT	VGNC	VGNC:80149
Rattus norvegicus	BRDT	RGD	RGD:1306678
Macaca mulatta	BRDT	VGNC	VGNC:70282
Canis familiaris	BRDT	VGNC	VGNC:38522
Mus musculus	BRDT	MGD	MGI:1891374
Others	BRDT	NCBI