Hidrosmin
Based on 1 Customer Validation
Hidrosmin, a flavonoid, is derived from Diosmin (HY-N0178). hidrosmin exerts a beneficial effect against diabetic nephropathy (DN) by reducing inflammation, oxidative stress, and senescence pathways. Hidrosmin can be used for the research of venous insufficiency and diabetes mellitus.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 95.34%
- No. CAS: 115960-14-0
- Fòrmula: C30H36O16
- Peso molecular:652.60
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Actividad biológica
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IL-1β |
NOX1 |
NOX4 |
Hidrosmin (0.1-1 mM) downregulates the cytokine expression in renal cells exposed to high-glucose and/or inflammatory conditions and also modulates redox balance genes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HK2 cells
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Concentration:0.1, 0.3, 1 mM
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Incubation Time:pretreated for 90 min with hidrosmin before stimulation with either high-glucose (30 mM D-Glucose (HY-B0389)) for 24 h, or a combination of human cytokines interleukin-6 (IL-6, 102 U/mL) and interfero
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Result:Reduced the gene expression of CC chemokines (CCL2 and CCL5) and proinflammatory cytokines (IL-1β and TNFα) induced by 24 h high-glucose stimulation. Restored the expression of redox balance genes by preventing the prooxidant enzyme NADPH oxidase (NOX1 and NOX4 isoforms) and promoting the expression of antioxidant enzymes Superoxide dismutase-1 (SOD1) and Catalase (CAT) in HK2 cells exposed to high-glucose, as well as to cytokines.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ApoE KO mice (14-16-week-old, induced T1D by streptozotocin injection)[1]
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Dosage:300 mg/kg/day, dissolved in tap water
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Administration:Orally through the feeding, once daily for 7 weeks (hidrosmin solution were renewed every 2-3 days)
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Result:Did not modify body weight, glycemia, and other biochemical parameters in diabetic mice, except for total cholesterol and low-density lipoprotein (LDL)-cholesterol, which presented a significant reduction when compared with the control group. Ameliorated renal dysfunction by reducing UACR levels. Showed a significant decrease in the urinary KIM-1 levels.
Chemical Information
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No. CAS 115960-14-0
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Appearance Solid
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Peso molecular 652.60
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Fòrmula C30H36O16
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Color White to off-white
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SMILES
OCCOC1=C2C(OC(C3=CC(O)=C(C=C3)OC)=CC2=O)=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)O)O)O)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hidrosmin Related Classifications
HY-105946 Related Classifications
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