country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-P991083

Copy Link Print Information

Biologically Validated

MAS825

Name: MAS825
Brand: MedChemExpress
SKU: HY-P991083
Price: 580.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Arumakimig)

Revisión del cliente

Based on 1 Customer Validation

MAS825 (Arumakimig) is a bispecific monoclonal antibody targeting IL-1β and IL-18. MAS825 reduces inflammatory infiltration and pulmonary alveolar proteinosis, and improves blood oxygen saturation, exercise tolerance and quality of life. MAS825 also promotes viral clearance. MAS825 can be used in research related to systemic juvenile idiopathic arthritis complicated with interstitial lung disease or macrophage activation syndrome, as well as COVID-19.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 95.83%
Peso molecular:144.353 kDa

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

MAS825 Chemical Structure

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Ensayo clínico
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Aplicación
- Verified Bioactivity
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Isotype

Ig(G1-kappa_G1-lambda2)

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

^[1]

IL-1β

IL-18

Ver todos los productos específicos de isoformas Interleukin Related :

In Vitro

MAS825 binds to and neutralizes these two cytokines to effectively block pro-inflammatory pathways.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

395196 [NCBI] & 3606 [NCBI]

Accession

O73909 & Q14116

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

IgG1-lambda-kappa

Aplicación

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized IL-1 beta Protein, Human (HY-P7028) can bind MAS825. The EC₅₀ for this effect is 3.057 ng/mL.
Immobilized IL-18 Protein, Human (HY-P70591) can bind MAS825. The EC₅₀ for this effect is 17.99 ng/mL.

Chemical Information

Appearance Liquid
Peso molecular 144.353 kDa
Color Colorless to light yellow
SMILES

N/A
Synonyms

Arumakimig
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (258 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Referencias

[1]. Rood J E, et al. Improvement of refractory systemic juvenile idiopathic arthritis-associated lung disease with single-agent blockade of IL-1β and IL-18[J]. Journal of clinical immunology, 2023, 43(1): 101-108.

[2]. Caorsi R, et al. Long-term efficacy of MAS825, a bispecific anti-IL1β and IL-18 monoclonal antibody, in two patients with systemic JIA and recurrent episodes of macrophage activation syndrome. Rheumatology (Oxford, England). 2025 Mar 01;64(3):1528-1533. [Content Brief]

[3]. Hakim A D, et al. Efficacy and safety of MAS825 (anti-IL-1β/IL-18) in COVID-19 patients with pneumonia and impaired respiratory function[J]. Clinical and experimental immunology, 2023, 213(3): 265-275.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto