NTZ-24
NTZ-24 is a selective STAT3 pathway inhibitor. NTZ-24 suppresses STAT3 phosphorylation at Tyr705, blocks STAT3-DNA interaction, and downregulates the levels of STAT3 downstream target proteins. NTZ-24 induces cell-cycle arrest and promotes apoptosis in cancer cells. NTZ-24 exerts significant antiproliferative activity against HeLa cells (IC50 = 3.3 μM). NTZ-24 can be used for the research of cervical cancer.
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- No. CAS: 69819-42-7
- Fòrmula: C10H5Cl2N3O3S
- Peso molecular:318.14
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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STAT3 0.8 μM (IC50) |
IL-6 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
3.3 μM
Compound: 24
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Cytotoxicity against human HeLa cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay
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[PMID: 34055214] |
NTZ-24 (compound 24) inhibits the IL-6/JAK/STAT3 pathway in HEK-Blue IL-6 cells with an IC50 of 0.8 μM[1].
NTZ-24 (48 h) inhibits the proliferation of HeLa epithelial carcinoma cells with an IC50 of 3.3 μM[1].
NTZ-24 (10-50 μM; 48 h) exhibits low cytotoxicity in human normal embryonic kidney HEK 293T cells, with 8.0% and 19.1% cell viability inhibition at 10 μM and 50 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 69819-42-7
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Peso molecular 318.14
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Fòrmula C10H5Cl2N3O3S
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SMILES
O=C(C1=CC=C(C(Cl)=C1)Cl)NC2=NC=C([N+]([O-])=O)S2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NTZ-24 Related Classifications
HY-182510 Related Classifications
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