Referencia número: HY-145927

NXP800

(Synonyms: CCT361814)

4 Cited Publications

Revisión del cliente

Based on 4 publication(s) in Google Scholar

NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has the potential for cancer research.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 99.86%
No. CAS: 1693734-80-3
Fòrmula: C₃₂H₃₂FN₅O₄
Peso molecular:569.63

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

NXP800 Chemical Structure

No. CAS: 1693734-80-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Ensayo clínico
Chemical Information
Publications (4)
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has the potential for cancer research^[1]^[2].

IC₅₀ & Target^[1]

HSF1

Ver todos los productos específicos de isoformas HSP :

Cellular Effect

Cell Line	Type	Value	Description	References
SK-OV-3	GI₅₀	8.5 nM Compound: 22; CCT361814	Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 96 hrs by resazurin dye based celltiter-blue viability assay Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 96 hrs by resazurin dye based celltiter-blue viability assay	[PMID: 37017629]
SK-OV-3	IC₅₀	94 nM Compound: 22; CCT361814	Inhibition of 17-AAG induced HSP72-expression in human SK-OV-3 cells incubated for 18 hrs by ELISA Inhibition of 17-AAG induced HSP72-expression in human SK-OV-3 cells incubated for 18 hrs by ELISA	[PMID: 37017629]

In Vitro

NXP800 (example 169) inhibits U20S cells viability (IC₅₀=0.056 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NXP800 (35 mg/kg; po; once daily for 20 days) inhibits the established SK-OV-3 human ovarian cancer solid tumor xenografts grown subcutaneously, with tumor growth inhibition (TGI) of 120% relative to control^[2].

Pharmacokinetic Analysis^[2]

Species	Route	Dose (mg/kg)	T_max (h)	AUC_last (ng·h/mL)	Cl_tb (mL/min/kg)	t_1/2 (h)	F (%)	AUC_u^0-t (h·nM)	Free C_av^0-24h (nM)	Cl_u (mL/min/kg)
mouse	po/iv	5/5	2.0	6000 (7800-4600) (po)	10 (10-9.7) (iv)	4.0	42 (po)	72	3.3	830 (iv)
rat	po/iv	5/1	6.0	2600 (po)	24 (iv)	3.1	45 (po)	86	3.7	730 (iv)
dog	po/iv	2.5/0.5	2.0	250 (po)	21 (iv)	1.4	9.1 (po)	35	1.9	150 (iv)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

No. CAS 1693734-80-3
Appearance Solid
Peso molecular 569.63
Fòrmula C₃₂H₃₂FN₅O₄
Color Light yellow to green yellow
SMILES

O=C(C1=CC=C2OCCOC2=C1)NC3=CC=C(C(NC(C4=CC5=C(N=C(CN6CCN(CC6)CC)C=C5)C=C4)=O)=C3)F
Synonyms

CCT361814
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (4)

All Apoptosis AnalysisIHCWBCell Proliferation/Viability AssayIF

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Journal Impact Factor

Int J Mol Sci

The Novel HSF1 Inhibitor NXP800 Exhibits Robust Antitumor Activity in Hepatocellular Carcinoma. [Abstract]

2026 Mar 19;27(6):2781. PMID: 41898642

NXP800 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2026 Mar 19;27(6):2781. [Abstract]

Cells treated with NXP800 at 50 nM concentration, either alone or in association with 5 OLA. Apoptosis was assessed in HLF.

NXP800 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2026 Mar 19;27(6):2781. [Abstract]

The P151 and P558 patient-derived organoids (PDOs) were treated with 500 nM NXP800 for 48 h, and levels of the proliferation marker Ki67, the apoptosis marker cleaved caspase 3, and the DNA damage marker phosphorylated/activated (p) histone H2A.X were evaluated immunohistochemically.

NXP800 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2026 Mar 19;27(6):2781. [Abstract]

HCC PDOs were treated with NXP800 for 48 h, and cell viability was evaluated via CellTiter-Glo®3D Luminescent Cell Viability Assay.
Int J Mol Sci

The Role of Heat Shock Factor 1 in Preserving Proteomic Integrity During Copper-Induced Cellular Toxicity. [Abstract]

2024 Oct 30;25(21):11657. PMID: 39519208

NXP800 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Oct 30;25(21):11657. [Abstract]

MIA PaCa-2 cells treated with the indicated dose of NXP800 (0, 25, 50 nM) for 24 h. Protein levels were detected by using Western blotting.

NXP800 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Oct 30;25(21):11657. [Abstract]

MIA PaCa-2 cells were treated with 25 nM NXP800 for 2 h, followed by 1 mM CuCl2 for 24 h. Aggresomes were imaged using a fluorescence microscope.
SSRN

2026 Apr 21.
bioRxiv

A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL. [Abstract]

2025 Dec 23:2025.12.21.694897. PMID: 41509383

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (175.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7555 mL

8.7776 mL

17.5553 mL

5 mM

0.3511 mL

1.7555 mL

3.5111 mL

10 mM

0.1756 mL

0.8778 mL

1.7555 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (272 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Keith Jones, et al. Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1. WO2015049535A1.

[2]. Pasqua AE, et al. HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies. J Med Chem. 2023 [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.7555 mL	8.7776 mL	17.5553 mL	43.8881 mL
	5 mM	0.3511 mL	1.7555 mL	3.5111 mL	8.7776 mL
	10 mM	0.1756 mL	0.8778 mL	1.7555 mL	4.3888 mL
	15 mM	0.1170 mL	0.5852 mL	1.1704 mL	2.9259 mL
	20 mM	0.0878 mL	0.4389 mL	0.8778 mL	2.1944 mL
	25 mM	0.0702 mL	0.3511 mL	0.7022 mL	1.7555 mL
	30 mM	0.0585 mL	0.2926 mL	0.5852 mL	1.4629 mL
	40 mM	0.0439 mL	0.2194 mL	0.4389 mL	1.0972 mL
	50 mM	0.0351 mL	0.1756 mL	0.3511 mL	0.8778 mL
	60 mM	0.0293 mL	0.1463 mL	0.2926 mL	0.7315 mL
	80 mM	0.0219 mL	0.1097 mL	0.2194 mL	0.5486 mL
	100 mM	0.0176 mL	0.0878 mL	0.1756 mL	0.4389 mL

Keywords

NXP800

4 Cited Publications

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NXP800

Cell Cycle/DNA Damage Compound Library

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Clinical Compound Library

Anti-Aging Compound Library

Cytoskeleton Compound Library

Orally Active Compound Library

Transcription Factor-Targeted Library

Heterocyclic Compound Library

Metabolic Enzyme Compound Library

Highly Selective Inhibitors Library

Anti-Ovarian Cancer Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) NXP800

Ver todos los productos específicos de isoformas HSP

Actividad biológica

Chemical Information

Publications (4)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

NXP800

Cell Cycle/DNA Damage Compound Library

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Clinical Compound Library

Anti-Aging Compound Library

Cytoskeleton Compound Library

Orally Active Compound Library

Transcription Factor-Targeted Library

Heterocyclic Compound Library

Metabolic Enzyme Compound Library

Highly Selective Inhibitors Library

Anti-Ovarian Cancer Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) NXP800

Ver todos los productos específicos de isoformas HSP

Actividad biológica

Chemical Information

Publications (4)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

NXP800 Related Classifications

HY-145927 Related Classifications