p-Cresyl sulfate potassium
Based on 6 publication(s) in Google Scholar
p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity.
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- Pureza : 99.97%
- No. CAS: 91978-69-7
- Fòrmula: C7H7KO4S
- Peso molecular:226.29
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) p-Cresyl sulfate potassium
More- Cell Metab. 2024 Aug 6;36(8):1806-1822.e11. [Abstract]
- Cell Death Dis. 2023 Feb 2;14(2):78. [Abstract]
- Phytomedicine. 2024 Dec:135:156174. [Abstract]
- Colloids Surf B Biointerfaces. 2024 Dec:244:114164. [Abstract]
- Electrochim Acta. 2025 Oct 26.
- ACS Appl Bio Mater. 2024 Jun 17;7(6):3841-3853. [Abstract]
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Actividad biológica
Descripciòn
IC50 & Target
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Microbial Metabolite |
Human Endogenous Metabolite |
In Vitro
p-Cresyl sulfate potassium (0.125 mM, 24 h) induces osteoblast dysfunction by activating JNK and p38 MAPK pathways[1].
p-Cresyl sulfate potassium (40 μg/mL, 30 min) inhibits adipogenesis and increases lipolysis of adipocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:Primary osteoblastic cells
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Concentration:0.05, 0.125, 0.25, 0.5 mM
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Incubation Time:24 h
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Result:Decreased cell viability in a dose-dependent manner.
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Cell Line:Primary osteoblastic cells
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Concentration:0.05, 0.125, 0.25, 0.5 mM
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Incubation Time:24 h
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Result:Increased DNA fragmentation and decreased cell proliferation.
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Cell Line:Primary osteoblastic cells
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Concentration:0.125 mM
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Incubation Time:24 h
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Result:Induced rapid and sustained phosphorylation of JNK.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CKD mice modrl[2]
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Dosage:10 mg/kg
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Administration:i.p.
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Result:Increased fasting plasma glucose concentration and plasma cholesterol levels.
Chemical Information
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No. CAS 91978-69-7
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Appearance Solid
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Peso molecular 226.29
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Fòrmula C7H7KO4S
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Color White to off-white
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SMILES
O=S(OC1=CC=C(C)C=C1)(O[K])=O
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Synonyms
p-Tolyl sulfate potassium
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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Cell Metab
Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer. [Abstract]2024 Aug 6;36(8):1806-1822.e11. PMID: 38897198 -
Cell Death Dis
3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) induces cell death through ferroptosis and acts as a trigger of apoptosis in kidney cells. [Abstract]2023 Feb 2;14(2):78. PMID: 36732325
p-Cresyl sulfate potassium purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2023 Feb 2;14(2):78. [Abstract]
HK-2 and NRK49F cells were treated with 400 μM IS, p-Cresyl sulfate (p-CS) and CMPF under serum starvation for 24 h and harvested. GPX4 protein levels in cells treated with 400 μM uremic toxin as detected by immunoblotting. The relative protein levels are shown.
p-Cresyl sulfate potassium purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2023 Feb 2;14(2):78. [Abstract]
HK-2 and NRK49F cells were treated with 400 μM IS, p-Cresyl sulfate (p-CS) and CMPF under serum starvation for 24 h and harvested. GPX4 protein levels in cells treated with uremic toxin as detected by flow cytometry. The graph on right shows the mean value of GPX4 fluorescence.
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Phytomedicine
Huangqi Jianzhong decoction improves gastric intestinal metaplasia in rats by regulating the gut‒thyroid axis. [Abstract]2024 Dec:135:156174. PMID: 39488101
p-Cresyl sulfate potassium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Dec:135:156174. [Abstract]
Indoxyl sulfate compromises mitochondrial function in Nthy-ori 3–1 cells. Survival rate of Nthy-ori 3–1 cells treated with p-Cresol sulfate.
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Colloids Surf B Biointerfaces
Trimethylamine N-oxide detection by electrochemical sensor based on screen printed electrode modified with molecularly imprinted polypyrrole-molybdenum(III) sulfide nanosheets. [Abstract]2024 Dec:244:114164. PMID: 39180990 -
p-Cresyl sulfate potassium purchased from MedChemExpress. Usage Cited in: Electrochim Acta. 2025 Oct 26.
FTIR spectra of pCS (p-Cresyl sulfate potassium).
p-Cresyl sulfate potassium purchased from MedChemExpress. Usage Cited in: Electrochim Acta. 2025 Oct 26.
IR spectra of pCS (p-Cresyl sulfate potassium).
p-Cresyl sulfate potassium purchased from MedChemExpress. Usage Cited in: Electrochim Acta. 2025 Oct 26.
Schematic of synthesis of Ppy-SnO2-rGO MIP and sensing of pCS (p-Cresyl sulfate potassium) in spiked urine samples with synthesized MIP.
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ACS Appl Bio Mater
4-Ethylphenyl Sulfate Detection by an Electrochemical Sensor Based on a MoS2 Nanosheet-Modified Molecularly Imprinted Biopolymer. [Abstract]2024 Jun 17;7(6):3841-3853. PMID: 38836520
Solvente y solubilidad
In Vitro:
DMSO : 125 mg/mL (552.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (441.91 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (220.96 mM); Clear solution; Need ultrasonic
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Protocolo
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (788 KB)
- English - EN (788 KB)
- Français - FR (788 KB)
- Deutsch - DE (788 KB)
- Norwegian - NO (788 KB)
- Español - ES (788 KB)
- Swedish - SV (788 KB)
- Italian - IT (788 KB)
- Korean - KR (788 KB)
- Portuguese - PT (788 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Tanaka H, et al, Fukagawa M. p-Cresyl sulfate induces osteoblast dysfunction through activating JNK and p38 MAPK pathways. Bone. 2013 Oct;56(2):347-54. [Content Brief]
[2]. Koppe L, et al. p-Cresyl sulfate promotes insulin resistance associated with CKD. J Am Soc Nephrol. 2013 Jan;24(1):88-99. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 4.4191 mL | 22.0955 mL | 44.1911 mL | 110.4777 mL |
| 5 mM | 0.8838 mL | 4.4191 mL | 8.8382 mL | 22.0955 mL | |
| 10 mM | 0.4419 mL | 2.2096 mL | 4.4191 mL | 11.0478 mL | |
| 15 mM | 0.2946 mL | 1.4730 mL | 2.9461 mL | 7.3652 mL | |
| 20 mM | 0.2210 mL | 1.1048 mL | 2.2096 mL | 5.5239 mL | |
| 25 mM | 0.1768 mL | 0.8838 mL | 1.7676 mL | 4.4191 mL | |
| 30 mM | 0.1473 mL | 0.7365 mL | 1.4730 mL | 3.6826 mL | |
| 40 mM | 0.1105 mL | 0.5524 mL | 1.1048 mL | 2.7619 mL | |
| 50 mM | 0.0884 mL | 0.4419 mL | 0.8838 mL | 2.2096 mL | |
| 60 mM | 0.0737 mL | 0.3683 mL | 0.7365 mL | 1.8413 mL | |
| 80 mM | 0.0552 mL | 0.2762 mL | 0.5524 mL | 1.3810 mL | |
| 100 mM | 0.0442 mL | 0.2210 mL | 0.4419 mL | 1.1048 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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