PRO-6E
Based on 1 Customer Validation
PRO-6E is an oral active PROTAC based on Cereblon ligand, and induces the degradation of MET with maximum degradation of 81.9% at 1 μM in MKN-45 cells. PRO-6E inhibits tumor growth in vivo and in vitro. PRO-6E induces cell apoptosis and induces cell arrest (Sturcture Note:(Blue: Cereblon ligand (HY-103596), Black: linker；Pink: ALK/c-Met inhibitor Crizotinib (HY-50878)).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.10%
- No. CAS: 2353493-69-1
- Fòrmula: C42H44Cl2FN7O7
- Peso molecular:848.75
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
PRO-6E (0.03-10 μM; 48 h) inhibits the cell growth in MKN-45, SNU-638 cells[1].
PRO‐6 E (1 μM; over 24 h) facilitates MET degradation in MKN-45 cells[1].
PRO‐6 E (0.1-1 μM; 48 h) increase in the percentage of G2/M phase cells and decrease in the percentage of S phase cells in MKN-45 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MKN-45, SNU-638 cells
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Concentration:0, 0.03, 0.1, 0.3, 1, 3, 10 μM
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Incubation Time:48 h
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Result:Inhibited the cell growth.
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Cell Line:MKN-45 cells
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Concentration:0, 0.1, 0.3, 1, 3 μM
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Incubation Time:48 h
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Result:Increased in the percentage of G2/M phase cells and decreased in the percentage of S phase cells.
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Cell Line:MKN-45 cells
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Concentration:0, 0.03, 0.1, 0.3, 1, 3 μM
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Incubation Time:12, 24, 36, 48, and 72 h
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Result:facilitated MET degradation over 24 hours.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MKN‐45 cell‐derived xenograft tumor model[1]
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Dosage:30 mg/kg/day for 15 days
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Administration:Oral gavage
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Result:Inhibited tumor growth.
Chemical Information
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No. CAS 2353493-69-1
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Appearance Solid
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Peso molecular 848.75
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Fòrmula C42H44Cl2FN7O7
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Color White to off-white
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SMILES
O=C1C2=C(OCCCCCCCC(N3CCC(N4C=C(C5=CN=C(N)C(O[C@@H](C6=C(C(F)=CC=C6Cl)Cl)C)=C5)C=N4)CC3)=O)C=CC=C2C(N1C7C(NC(CC7)=O)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : ≥ 100 mg/mL (117.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1782 mL | 5.8910 mL | 11.7820 mL | 29.4551 mL |
| 5 mM | 0.2356 mL | 1.1782 mL | 2.3564 mL | 5.8910 mL | |
| 10 mM | 0.1178 mL | 0.5891 mL | 1.1782 mL | 2.9455 mL | |
| 15 mM | 0.0785 mL | 0.3927 mL | 0.7855 mL | 1.9637 mL | |
| 20 mM | 0.0589 mL | 0.2946 mL | 0.5891 mL | 1.4728 mL | |
| 25 mM | 0.0471 mL | 0.2356 mL | 0.4713 mL | 1.1782 mL | |
| 30 mM | 0.0393 mL | 0.1964 mL | 0.3927 mL | 0.9818 mL | |
| 40 mM | 0.0295 mL | 0.1473 mL | 0.2946 mL | 0.7364 mL | |
| 50 mM | 0.0236 mL | 0.1178 mL | 0.2356 mL | 0.5891 mL | |
| 60 mM | 0.0196 mL | 0.0982 mL | 0.1964 mL | 0.4909 mL | |
| 80 mM | 0.0147 mL | 0.0736 mL | 0.1473 mL | 0.3682 mL | |
| 100 mM | 0.0118 mL | 0.0589 mL | 0.1178 mL | 0.2946 mL |
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