PS21M
PS21M is a negative control PROTAC degrader derived from CPS-021, as well as an inhibitor of ternary complex formation. PS21M attenuates the interaction with Cereblon ligase, restricting the formation of the PAK4-PROTAC-Cereblon ternary complex and the subsequent degradation of PAK4. PS21M serves as a negative control molecule to verify the degradation mechanism of CPS-021.
(Pink: PAK4 ligand (HY-174822); Blue: Cereblon ligand (HY-W586822); Black: linker).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C53H65N11O7
- Peso molecular:968.15
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 human breast cancer cells
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Concentration:2, 5 μM
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Incubation Time:4 h
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Result:Attenuated CPS-021-induced PAK4 degradation, resulting in a PAK4 relative abundance of 1.13 versus the untreated control (set at 1.00).
Chemical Information
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Peso molecular 968.15
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Fòrmula C53H65N11O7
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SMILES
O=C(C1=CN(C2=NC(N)=NC=C2)C3=C1C=CC(C#CC4(O)CCCCC4)=C3)N5CCN(CC5)CCCCCCCC(N6CCN(CCNC7=CC=CC(C(N8C9CCC(N(C)C9=O)=O)=O)=C7C8=O)CC6)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PS21M Related Classifications
HY-174248 Related Classifications
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