Sarolaner
Based on 1 publication(s) in Google Scholar
Sarolaner (PF-6450567) is an orally active and broad-spectrum ectoparasiticide. Sarolaner is an isoxazoline compound which shows efficacy against fleas and ticks on dogs, with a LC80 value of 0.3 μg/mL against C. felis and a LC100 value of 0.003 μg/mL against O. turicata.
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- Pureza: 99.19%
- No. CAS: 1398609-39-6
- Fòrmula: C23H18Cl2F4N2O5S
- Peso molecular:581.36
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Sarolaner
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Actividad biológica
LC80: 0.3μg/mL (C. felis)[1]
LC100: 0.003 μg/mL (O. turicata)[1]
IC50: 135 nM (CfRDL-A285), 136 nM (CfRDL-S285)[1]
Sarolaner (450 nM-1 mM; 5 min) inhibits CfRDL-A285 and CfRDL-S285 receptors with γ-Aminobutyric acid (GABA)-induced currents[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CHO-K1 cell lines
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Concentration:450 nM-1 mM
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Incubation Time:5 min
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Result:Inhibited GABA-elicited currents at both susceptible (CfRDL-A285) and resistant (CfRDL-S285) flea GABACls with EC50s of 135 and 136 nM, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Dog infested with R. sanguineus and D. reticulatus[1]
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Dosage:2.5 mg/kg
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Administration:Oral gavage; 2.5 mg/kg once
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Result:Exibited 100% efficacy against R. sanguineus at 48 hours after treatment and also exhibited 98.0% efficacy againstD. reticulatus.
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Animal Model:Dog infested with I. ricinus[1]
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Dosage:1.25, 2.5 and 5 mg/kg
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Administration:Oral gavage; 1.25, 2.5 and 5 mg/kg once
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Result:Exibited 100% efficacy against I. ricinus at all doses until 7 days, and provided over 99.3% reduction against subsequent re-infestations until 57 days at dose of 5.0 and 2.5 mg/kg.
Chemical Information
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No. CAS 1398609-39-6
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Appearance Solid
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Peso molecular 581.36
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Fòrmula C23H18Cl2F4N2O5S
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Color White to off-white
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SMILES
O=S(CC(N1CC2(OCC3=C2C=CC(C4=NO[C@](C(F)(F)F)(C5=CC(Cl)=C(F)C(Cl)=C5)C4)=C3)C1)=O)(C)=O
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Synonyms
PF-6450567
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Pest Manag Sci
Repurposing isoxazoline insecticides to control Varroa destructor populations in honey bee colonies. [Abstract]2025 Oct 2. PMID: 41039832
Solvente y solubilidad
DMSO : 300 mg/mL (516.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 7.5 mg/mL (12.90 mM); Clear solution
This protocol yields a clear solution of ≥ 7.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (75.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (540 KB)
- English - EN (540 KB)
- Français - FR (540 KB)
- Deutsch - DE (540 KB)
- Norwegian - NO (540 KB)
- Español - ES (540 KB)
- Swedish - SV (540 KB)
- Italian - IT (540 KB)
- Korean - KR (540 KB)
- Portuguese - PT (540 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7201 mL | 8.6005 mL | 17.2010 mL | 43.0026 mL |
| 5 mM | 0.3440 mL | 1.7201 mL | 3.4402 mL | 8.6005 mL | |
| 10 mM | 0.1720 mL | 0.8601 mL | 1.7201 mL | 4.3003 mL | |
| 15 mM | 0.1147 mL | 0.5734 mL | 1.1467 mL | 2.8668 mL | |
| 20 mM | 0.0860 mL | 0.4300 mL | 0.8601 mL | 2.1501 mL | |
| 25 mM | 0.0688 mL | 0.3440 mL | 0.6880 mL | 1.7201 mL | |
| 30 mM | 0.0573 mL | 0.2867 mL | 0.5734 mL | 1.4334 mL | |
| 40 mM | 0.0430 mL | 0.2150 mL | 0.4300 mL | 1.0751 mL | |
| 50 mM | 0.0344 mL | 0.1720 mL | 0.3440 mL | 0.8601 mL | |
| 60 mM | 0.0287 mL | 0.1433 mL | 0.2867 mL | 0.7167 mL | |
| 80 mM | 0.0215 mL | 0.1075 mL | 0.2150 mL | 0.5375 mL | |
| 100 mM | 0.0172 mL | 0.0860 mL | 0.1720 mL | 0.4300 mL |
Sarolaner Related Classifications
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