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Referencia número: HY-164527

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Si306

Si306 is a Src inhibitor with antitumor activity. Si306 reduces the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), and inhibits the invasion of human glioblastoma (GBM).

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No. CAS: 1640012-88-9
Fòrmula: C₂₅H₂₆BrClN₆OS
Peso molecular:573.94

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Si306 Chemical Structure

No. CAS: 1640012-88-9

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
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Bioz

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Src :

Ver todos los productos específicos de isoformas EGFR :

Cellular Effect

Cell Line	Type	Value	Description	References
SH-SY5Y	IC₅₀	0.34 μM Compound: 29	Antiproliferative activity against human SH-SY5Y cells after 24 hrs Antiproliferative activity against human SH-SY5Y cells after 24 hrs	[PMID: 25469771]
U-87MG ATCC	IC₅₀	1.9 μM Compound: 4	Cytotoxicity against human U87 cells assessed as reduction in cell viability after 72 hrs by trypan blue assay Cytotoxicity against human U87 cells assessed as reduction in cell viability after 72 hrs by trypan blue assay	[PMID: 28650650]
U-87MG ATCC	IC₅₀	17.3 μM Compound: 4	Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs by trypan blue assay Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs by trypan blue assay	[PMID: 28650650]
U-87MG ATCC	IC₅₀	6.8 μM Compound: 4	Cytotoxicity against human U87 cells assessed as reduction in cell viability after 48 hrs by trypan blue assay Cytotoxicity against human U87 cells assessed as reduction in cell viability after 48 hrs by trypan blue assay	[PMID: 28650650]

Chemical Information

No. CAS 1640012-88-9
Peso molecular 573.94
Fòrmula C₂₅H₂₆BrClN₆OS
SMILES

BrC1=CC(NC2=NC(SCCN3CCOCC3)=NC4=C2C=NN4CC(Cl)C5=CC=CC=C5)=CC=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Nešović, et al. "Src Inhibitors Pyrazolo [3, 4-d] pyrimidines, Si306 and Pro-Si306, inhibit focal adhesion kinase and suppress human glioblastoma invasion in vitro and in vivo." Cancers 12.6 (2020): 1570. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Si306

Ver todos los productos específicos de isoformas Src

Ver todos los productos específicos de isoformas EGFR

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Si306 Related Classifications

HY-164527 Related Classifications