SRT3657
SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1383551-17-4
- Fòrmula: C40H54N8O6S
- Peso molecular:774.97
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
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HY-15452
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CAY10602SIRT1 Activator -
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Selisistat (Standard)SirT1/Sir2 Inhibitor -
HY-15145A
SRT 1720 dihydrochlorideSIRT1 Activator
Actividad biológica
Descripciòn
IC50 & Target
SIRT1[1]
In Vivo
SRT3657 treatment prevents synaptic and neuronal loss and effectively rescues against neurodegeneration-driven memory impairments[1].
SRT3657 recapitulates the neuroprotective potential of caloric restriction (CR)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult double-transgenic CK-p25 mice (3-month-old)[1]
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Dosage:30 mg/kg
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Administration:Oral gavage, daily, for 6 weeks
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Result:Significantly upregulated the activity of SIRT1 in hippocampal extracts of CK-p25 animals.
Chemical Information
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No. CAS 1383551-17-4
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Peso molecular 774.97
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Fòrmula C40H54N8O6S
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SMILES
O=C(N1CCC(OCC2=CN=C(SC(C3=CC=CC=C3NC(C4=NC(CCCC)=NC(NCCN(C(OC(C)(C)C)=O)C)=C4)=O)=N5)C5=C2)CC1)OC(C)(C)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SRT3657 Related Classifications
HY-136094 Related Classifications
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