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Referencia número: HY-190554

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STK436742

STK436742 is a TRPV1 channel antagonist. STK436742 has anti-Amyloid-β propagation and anticancer effects. STK436742 can be used for pain research.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 610266-79-0
Fòrmula: C₁₈H₁₄N₂O₃
Peso molecular:306.32

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

STK436742 Chemical Structure

No. CAS: 610266-79-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

STK436742 is a TRPV1 channel antagonist. STK436742 has anti-Amyloid-β propagation and anticancer effects. STK436742 can be used for pain research^[1].

IC₅₀ & Target

^[1]

TRPV1

Ver todos los productos específicos de isoformas TRP Channel :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC50	4.35 μM	Inhibition of capsaicin-induced TRPV1 calcium influx in HEK293 cells stably expressing TRPV1 assessed by FDSS/μCELL fluorescence Ca2+ assay using Fluo-4 AM after 20 min compound incubation. Inhibition of capsaicin-induced TRPV1 calcium influx in HEK293 cells stably expressing TRPV1 assessed by FDSS/μCELL fluorescence Ca2+ assay using Fluo-4 AM after 20 min compound incubation.	42732743
HEK293	IC50	0.69 μM	Inhibition of capsaicin-induced TRPV1 transmembrane currents in HEK293 cells stably expressing TRPV1 assessed by whole-cell patch-clamp electrophysiology at +100 mV after 1 min compound application. Inhibition of capsaicin-induced TRPV1 transmembrane currents in HEK293 cells stably expressing TRPV1 assessed by whole-cell patch-clamp electrophysiology at +100 mV after 1 min compound application.	42732743

In Vitro

STK436742 (0.005-100 μM; 20 min) inhibits Capsaicin (HY-10448)-induced TRPV1 calcium influx in TRPV1-expressing HEK293 cells with an FDSS IC₅₀ of 4.35 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

No. CAS 610266-79-0
Peso molecular 306.32
Fòrmula C₁₈H₁₄N₂O₃
SMILES

OC1=C2C(C=CC=C2)=CC=C1C(N/N=C/C3=CC=CC(O)=C3)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Guo Y, et al. Discovery and mechanism analysis of novel TRPV1 antagonists driven by multi-dimensional virtual screening and dynamic simulation. European journal of medicinal chemistry. 2026 Sep 10;320:119311.

Calculators

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Calculadora de dilución

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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