Thermopsoside
Based on 1 Customer Validation
Thermopsoside is a CYP450 isoenzyme inhibitor and PXR activator. Thermopsoside inhibits CYP3A4, CYP2C19, CYP2D6 and CYP2C9 with IC50 values of 6.0 μM, 9.5 μM, 12.0 μM and 32.0 μM, respectively.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.0%
- No. CAS: 19993-32-9
- Fòrmula: C22H22O11
- Peso molecular:462.40
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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CYP2 |
CYP3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
>20 μM
Compound: chrysoeriol-7-O-beta-D-glucopyranoside
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Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite accumulation after 24 hrs by Griess reagent method
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite accumulation after 24 hrs by Griess reagent method
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[PMID: 19778086] |
| Vero | CC50 |
200 μM
Compound: 5
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Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
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[PMID: 23354072] |
Thermopsoside (0.3-30 μM; 48 h) activates PXR but exerts only marginal effects on the mRNA expression of CYP3A4, CYP1A2, CYP2C9, and P-gp in transiently transfected HepG2 cells[1].
Thermopsoside (100 μM; 10 min pre-incubation, 1 h with calcein-AM) does not inhibit P-glycoprotein activity in hMDR1-MDCK-II cells at 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Transiently transfected HepG2 cells
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Concentration:0.3-30 μM
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Incubation Time:48 h
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Result:Exerted marginal effects on the mRNA expression of CYP3A4, CYP1A2, CYP2C9, and P-gp.
Chemical Information
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No. CAS 19993-32-9
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Appearance Solid
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Peso molecular 462.40
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Fòrmula C22H22O11
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Color White to off-white
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SMILES
O=C1C2=C(O)C=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)C=C2OC(C4=CC(OC)=C(O)C=C4)=C1
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thermopsoside Related Classifications
HY-N6023 Related Classifications
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