Referencia número: HY-14443

XMD8-92

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XMD8-92 is a potent ERK5 (BMK1)/BRD4 inhibitor with K_ds of 80 and 190 nM, respectively. XMD8-92 inhibits DCAMKL2, PLK4 and TNK1 with K_ds of 190, 600 and 890 nM, respectively. Anti-cancer activity.

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Pureza: 99.48%
No. CAS: 1234480-50-2
Fòrmula: C₂₆H₃₀N₆O₃
Peso molecular:474.55

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

XMD8-92 Chemical Structure

No. CAS: 1234480-50-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (17)
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

BMK1

80 nM (Kd)

BRD4

190 nM (Kd)

DCAMKL1

Ver todos los productos específicos de isoformas Epigenetic Reader Domain :

Ver todos los productos específicos de isoformas CaMK :

Ver todos los productos específicos de isoformas ERK :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC₅₀	>10000 nM Compound: XMD8-92	Inhibition of cell growth in HEK293T cells incubated for 72 hrs by CellTiter-blue reagent based assay Inhibition of cell growth in HEK293T cells incubated for 72 hrs by CellTiter-blue reagent based assay	[PMID: 34710325]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of ABL1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ABL1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of AGK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of AGK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of AKT1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of AKT1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of ALS2CR2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ALS2CR2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of AMPKalpha1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of AMPKalpha1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of AMPKalpha1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of AMPKalpha1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of AMPKalpha1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of AMPKalpha1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of AMPKalpha2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of AMPKalpha2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of ARAF in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ARAF in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of ATM in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ATM in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of ATR in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ATR in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of AURA in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of AURA in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of AURA/AURB/AURC in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of AURA/AURB/AURC in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of AXL in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of AXL in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of BRAF in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of BRAF in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of BRAF in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of BRAF in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CAMK1d in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CAMK1d in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CAMK1d in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CAMK1d in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CAMK2d in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CAMK2d in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CAMK2d in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CAMK2d in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CAMK2g in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CAMK2g in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CAMK2g in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CAMK2g in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CAMKK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CAMKK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CASK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CASK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDC2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDC2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK10 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK10 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK2 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK2 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK2 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK2 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK5 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK5 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK5 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK5 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK5/PRKX/PRKY in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK5/PRKX/PRKY in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK5/PRKX/PRKY in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK5/PRKX/PRKY in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK7 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK7 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK8/CDK11 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK8/CDK11 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK9 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK9 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK9 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK9 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CHED in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CHED in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CHED in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CHED in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CHK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CHK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CHK1 inactive site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CHK1 inactive site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CHK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CHK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CK1alpha in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CK1alpha in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CK1g1/g2/g3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CK1g1/g2/g3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CLK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CLK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of COT in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of COT in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CRK7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CRK7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CSK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CSK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of CSK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CSK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of EEF2K in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of EEF2K in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of EGFR in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of EGFR in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of EGFR in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of EGFR in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of EphA2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of EphA2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of EphB4 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of EphB4 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of EphB4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of EphB4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of ERK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ERK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of ERK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ERK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of ERK2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ERK2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of ERK4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ERK4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of FER in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of FER in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of FRAP in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of FRAP in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of FYN in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of FYN in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of GCK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of GCK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of GCN2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of GCN2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of GSK3A in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of GSK3A in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of GSK3B isoform 2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of GSK3B isoform 2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of GSK3B isoform 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of GSK3B isoform 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of HGK/MINK/TNIK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of HGK/MINK/TNIK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of HGK/MINK/TNIK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of HGK/MINK/TNIK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of IGF1R in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of IGF1R in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of IKKA in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of IKKA in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of IKKB in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of IKKB in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of IKKE/TBK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of IKKE/TBK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of ILK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ILK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of INSR in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of INSR in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of IRAK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of IRAK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of IRAK4 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of IRAK4 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of IRAK4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of IRAK4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of IRE1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of IRE1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of JAK1 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of JAK1 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of JAK1 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of JAK1 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of JNK1/JNK2/JNK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of JNK1/JNK2/JNK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of KHS1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of KHS1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of LATS1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of LATS1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of LATS2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of LATS2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of LOK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of LOK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of LOK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of LOK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of LYN in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of LYN in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K1/MAP2K2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K1/MAP2K2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K1/MAP2K2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K1/MAP2K2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K4 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K4 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K5 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K5 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K6 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K6 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K6 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K6 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP3K1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP3K1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP3K2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP3K2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP3K2/MAP3K3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP3K2/MAP3K3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP3K2/MAP3K3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP3K2/MAP3K3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP3K4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP3K4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP3K5 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP3K5 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP3K5/MAP3K6/MAP3K15 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP3K5/MAP3K6/MAP3K15 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MARK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MARK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MARK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MARK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MARK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MARK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MARK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MARK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAST3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAST3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MASTL in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MASTL in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MET in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MET in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MLK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MLK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MLKL in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MLKL in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MLKL in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MLKL in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MPSK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MPSK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MRCKB in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MRCKB in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MSK1 domain 1 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MSK1 domain 1 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MSK1 domain 1 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MSK1 domain 1 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MSK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MSK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MSK1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MSK1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MSK1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MSK1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MST1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MST1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MST1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MST1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MST1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MST1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MST1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MST1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MST2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MST2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MST3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MST3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MST3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MST3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MST4/YSK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MST4/YSK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of MST4/YSK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MST4/YSK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of NDR1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NDR1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of NDR2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NDR2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK6/7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK6/7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK6/7 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK6/7 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK7 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK7 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK8 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK8 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK9 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK9 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK9 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK9 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of P38a in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of P38a in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of P38a interaction site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of P38a interaction site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of P38delta/gamma in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of P38delta/gamma in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of P70S6K in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of P70S6K in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of P70S6KB in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of P70S6KB in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PAN3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PAN3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PCTAIRE1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PCTAIRE1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PCTAIRE2/ICK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PCTAIRE2/ICK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PCTAIRE2/PCTAIRE3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PCTAIRE2/PCTAIRE3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PDK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PDK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PEK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PEK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PFTAIRE2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PFTAIRE2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PHKg2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PHKg2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PHKg2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PHKg2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIK3C2B in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIK3C2B in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIK3C3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIK3C3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIK4CB in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIK4CB in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIP5K2A in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIP5K2A in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIP5K2A in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIP5K2A in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIP5K2A LIP1 labeling site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIP5K2A LIP1 labeling site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIP5K2A LIP1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIP5K2A LIP1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIP5K2B in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIP5K2B in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIP5K2C in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIP5K2C in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIP5K3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIP5K3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PITSLRE in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PITSLRE in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKCalpha/beta in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKCalpha/beta in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKCiota in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKCiota in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKCtheta in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKCtheta in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKCzeta in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKCzeta in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKD1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKD1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKD2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKD2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKD3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKD3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKN2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKN2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKR in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKR in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKR in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKR in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PLK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PLK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PLK1 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PLK1 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PLK1 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PLK1 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PLK1 splice variant in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PLK1 splice variant in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PRKDC in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PRKDC in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PRKDC in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PRKDC in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PRKX/PRKY in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PRKX/PRKY in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PRP4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PRP4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PRPK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PRPK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of PRPK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PRPK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of ROCK1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ROCK1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of RON in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RON in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK1 domain 1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK1 domain 1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK1/2/3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK1/2/3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK1/RSK2/RSK3 domain 1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK1/RSK2/RSK3 domain 1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK2 domain 1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK2 domain 1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of SGK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SGK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of SGK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SGK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of SGK3 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SGK3 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of SGK3 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SGK3 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of SLK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SLK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of SLK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SLK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of SMG1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SMG1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of SRC/FYN/YES in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SRC/FYN/YES in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of SRPK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SRPK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of SRPK1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SRPK1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of TAK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of TAK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of TAO2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of TAO2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of TAO3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of TAO3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of TIF1b in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of TIF1b in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of TLK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of TLK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of TLK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of TLK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of ULK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ULK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of ULK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ULK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of ULK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ULK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of Wee1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of Wee1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of Wnk1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of Wnk1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of Wnk1/2/4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of Wnk1/2/4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	>50 μM Compound: Chemical probe : XMD8-92	Inhibition of ZAK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ZAK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	1.5 μM Compound: Chemical probe : XMD8-92	Inhibition of ERK5 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ERK5 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	10 μM Compound: Chemical probe : XMD8-92	Inhibition of TNK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of TNK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	18 μM Compound: Chemical probe : XMD8-92	Inhibition of ACK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ACK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	26 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK1 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK1 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	29 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK1 domain 2 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK1 domain 2 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	31 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK1 domain 2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK1 domain 2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	34 μM Compound: Chemical probe : XMD8-92	Inhibition of PIK4CB in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIK4CB in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	36 μM Compound: Chemical probe : XMD8-92	Inhibition of PIK4CA in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIK4CA in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	39 μM Compound: Chemical probe : XMD8-92	Inhibition of FAK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of FAK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	47 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK2 domain 2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK2 domain 2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	49 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK2 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK2 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	0.24 μM Compound: 18	Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysis Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysis	[PMID: 21412406]
HeLa	IC₅₀	300 nM Compound: 2; XMD8-92	Inhibition of ERK5 in human HeLa cells incubated for 15 mins prior to ATP addition by KiNativ profiling method Inhibition of ERK5 in human HeLa cells incubated for 15 mins prior to ATP addition by KiNativ profiling method	[PMID: 31212132]
HeLa	IC₅₀	>50 μM Compound: 4; XMD8-92	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs	[PMID: 32078308]
HL-60	IC₅₀	10.59 μM Compound: 4; XMD8-92	Antiproliferative activity against human HL60 cells assessed as reduction in cell viability measured after 24 hrs Antiproliferative activity against human HL60 cells assessed as reduction in cell viability measured after 24 hrs	[PMID: 32078308]
MKN-74	IC₅₀	>50 μM Compound: 4; XMD8-92	Antiproliferative activity against human MKN74 cells assessed as reduction in cell viability measured after 24 hrs Antiproliferative activity against human MKN74 cells assessed as reduction in cell viability measured after 24 hrs	[PMID: 32078308]
MM1.S	IC₅₀	2100 nM Compound: XMD8-92	Inhibition of cell growth in human MM1.S cells incubated for 72 hrs by CellTiter-blue reagent based assay Inhibition of cell growth in human MM1.S cells incubated for 72 hrs by CellTiter-blue reagent based assay	[PMID: 34710325]

In Vitro

XMD8-92 (0-5 Μm; 48 hours) inhibits the proliferation of HMEC and cancer cells^[1].
XMD8-92 effectively inhibits BMK1 activation as well as induces PML’s (promyelocytic leukemia protein) downstream effector, p21. XMD8-92 significantly inhibits basic fibroblast growth factor (bFGF) induced angiogenesis in Matrigel plugs. XMD8-92 significantly induces p21 expression in HeLa and A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HMEC, A549 and HeLa cells
Concentration:

0.16, 0.32, 0.63, 1.25, 2.5 or 5 μM
Incubation Time:

48 hours
Result:

Inhibited the proliferation of HMEC and cancer cells.

In Vivo

XMD8-92 (i.p.; twice a day for 28 days) significantly inhibits the growth of the xenografted human tumors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

HeLa Xenograft Model (6-week-old Nod/Scid mice)^[1]
Dosage:

50 mg/kg
Administration:

I.p.; twice a day for 28 days
Result:

Significantly inhibited the growth of the xenografted human tumors.

Chemical Information

No. CAS 1234480-50-2
Appearance Solid
Peso molecular 474.55
Fòrmula C₂₆H₃₀N₆O₃
Color Off-white to light yellow
SMILES

CN(C1=O)C2=CN=C(N=C2N(C3=C1C=CC=C3)C)NC4=C(C=C(C=C4)N5CCC(CC5)O)OCC
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (17)

All WB

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Journal Impact Factor

Cancer Cell

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. [Abstract]

2018 Nov 12;34(5):807-822. PMID: 30423298
ACS Nano

Nanopore Discrimination of Protein-Small-Molecule Drug Complexes at Near-Atomic Resolution. [Abstract]

2026 May 12;20(18):13624-13635. PMID: 42046448
Nat Commun

Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]

2026 Feb 12;17(1):1214. PMID: 41680175
Adv Sci (Weinh)

Neuroendocrine Regulation of Stress-Induced T Cell Dysfunction during Lung Cancer Immunosurveillance via the Kisspeptin/GPR54 Signaling Pathway. [Abstract]

2022 May;9(13):e2104132. PMID: 35224894
Cancer Lett

Inhibition of MEK5/ERK5 signaling overcomes acquired resistance to the third generation EGFR inhibitor, osimertinib, via enhancing Bim-dependent apoptosis. [Abstract]

2021 Oct 28:519:141-149. PMID: 34245854
EMBO Mol Med

ERK5 suppression overcomes FAK inhibitor resistance in mutant KRAS-driven non-small cell lung cancer. [Abstract]

2024 Oct;16(10):2402-2426. PMID: 39271958
Sci Signal

The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma. [Abstract]

2014 Oct 28;7(349):ra102. PMID: 25351247

XMD8-92 purchased from MedChemExpress. Usage Cited in: Sci Signal. 2014 Oct 28;7(349):ra102. [Abstract]

Activation of ERK5 in neuroblastoma cell lines expressing activated ALK. (A to C) Immunoblotting for the indicated proteins in neuroblastoma cells CLB-BAR (A), CLB-GE (B), and IMR32 (C) cultured on six-well plates in complete growth medium and treated with inhibitors as indicated for 6 hours alone (A and B) or before (C) stimulation with mAb46 for 30 min.
Cancer Cell Int

Construction of a prognostic model with histone modification-related genes and identification of potential drugs in pancreatic cancer. [Abstract]

2021 Jun 5;21(1):291. PMID: 34090418
Chem Biol Interact

Platycodin D reverses tumor necrosis factor-α-induced endothelial dysfunction by increasing nitric oxide through G protein-coupled estrogen receptor-mediated eNOS activity. [Abstract]

2025 May 28:111577. PMID: 40447174
Stem Cell Reports

Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells. [Abstract]

2018 Oct 9;11(4):929-943. PMID: 30245209

XMD8-92 purchased from MedChemExpress. Usage Cited in: Stem Cell Reports. 2018 Oct 9;11(4):929-943. [Abstract]

Immunoblotting of total cell lysates of CML cell lines; tubulin is a loading control; representative images from four independent experiments.
Mol Oncol

Importin subunit beta-1 mediates ERK5 nuclear translocation, and its inhibition synergizes with ERK5 kinase inhibitors in reducing cancer cell proliferation. [Abstract]

2025 Jan;19(1):99-113. PMID: 38965815
Target Oncol

In Vitro Comparison of the Effects of Imatinib and Ponatinib on Chronic Myeloid Leukemia Progenitor/Stem Cell Features. [Abstract]

2020 Oct;15(5):659-671. PMID: 32780298
Am J Pathol

Latent-Transforming Growth Factor β-Binding Protein 1/Transforming Growth Factor β1 Complex Drives Antitumoral Effects upon ERK5 Targeting in Melanoma. [Abstract]

2024 Aug;194(8):1581-1591. PMID: 38705382
BMC Cancer

Artificial intelligence to guide precision anticancer therapy with multitargeted kinase inhibitors. [Abstract]

2022 Nov 24;22(1):1211. PMID: 36434556
PLoS One

ERK5 activation is essential for osteoclast differentiation. [Abstract]

2015 Apr 17;10(4):e0125054. PMID: 25885811

XMD8-92 purchased from MedChemExpress. Usage Cited in: PLoS One. 2015 Apr 17;10(4):e0125054. [Abstract]

The induction of c-Fos is blocked by inhibition of the ERK5 pathway. 4B12 cells (2.5 × 10⁴) are pretreated with or without BIX02189 or XMD8-92 for 6 hrs and then cultured in the presence of M-CSF (10 ng/mL) for 24 hrs. The expression of c-Fos is measured by Western blot analysis.
bioRxiv

2026 May 7.
Harvard Medical School LINCS LIBRARY

Solvente y solubilidad

In Vitro:

DMSO : 50 mg/mL (105.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1073 mL

10.5363 mL

21.0726 mL

5 mM

0.4215 mL

2.1073 mL

4.2145 mL

10 mM

0.2107 mL

1.0536 mL

2.1073 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (277 KB)
SDS (393 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Yang Q, et al. Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein.Cancer Cell. 2010 Sep 14;18(3):258-67. [Content Brief]

[2]. Yang Q, et al. Targeting the BMK1 MAP kinase pathway in cancer therapy. Clin Cancer Res. 2011 Jun 1;17(11):3527-32. [Content Brief]

[3]. Lin EC, et al. ERK5 kinase activity is dispensable for cellular immune response and proliferation. Proc Natl Acad Sci U S A. 2016;113(42):11865-11870. [Content Brief]

[4]. Umapathy G, et al. The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma. Sci Signal. 2014 Oct 28;7(349):ra102. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1073 mL	10.5363 mL	21.0726 mL	52.6815 mL
	5 mM	0.4215 mL	2.1073 mL	4.2145 mL	10.5363 mL
	10 mM	0.2107 mL	1.0536 mL	2.1073 mL	5.2681 mL
	15 mM	0.1405 mL	0.7024 mL	1.4048 mL	3.5121 mL
	20 mM	0.1054 mL	0.5268 mL	1.0536 mL	2.6341 mL
	25 mM	0.0843 mL	0.4215 mL	0.8429 mL	2.1073 mL
	30 mM	0.0702 mL	0.3512 mL	0.7024 mL	1.7560 mL
	40 mM	0.0527 mL	0.2634 mL	0.5268 mL	1.3170 mL
	50 mM	0.0421 mL	0.2107 mL	0.4215 mL	1.0536 mL
	60 mM	0.0351 mL	0.1756 mL	0.3512 mL	0.8780 mL
	80 mM	0.0263 mL	0.1317 mL	0.2634 mL	0.6585 mL
	100 mM	0.0211 mL	0.1054 mL	0.2107 mL	0.5268 mL

Keywords

XMD8-92

17 Cited Publications

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XMD8-92

Epigenetics Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

MAPK Compound Library

Neuronal Signaling Compound Library

Stem Cell Signaling Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Chemical Probe Library

Glutamine Metabolism Compound Library

Anti-Blood Cancer Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Heterocyclic Compound Library

Pain-Related Compound Library

Highly Selective Inhibitors Library

Serine/Threonine Kinase Inhibitor Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

Bioactive Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) XMD8-92

Ver todos los productos específicos de isoformas Epigenetic Reader Domain

Ver todos los productos específicos de isoformas CaMK

Ver todos los productos específicos de isoformas ERK

Actividad biológica

Chemical Information

Publications (17)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

XMD8-92 Related Classifications

Referencia número: HY-14443