YCW-E11
YCW-E11 is a Bcl-2, and Mcl-1 inhibitor with Ki values of 0.83 and 0.33 μM, respectively. YCW-E11 induces cell apoptosis through the mitochondrial pathway and exhibits antitumor activity. YCW-E11 can be utilized in cancer research.
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- No. CAS: 1519043-97-0
- Fòrmula: C25H21Cl2N3O6S2
- Peso molecular:594.49
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Bcl-2 |
Mcl-1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | IC50 |
10.7 μM
Compound: YCW-E11
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Cytotoxicity against HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Cytotoxicity against HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
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[PMID: 34228434] |
| HeLa | IC50 |
>50 μM
Compound: YCW-E11
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Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
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[PMID: 34228434] |
| HL-60 | IC50 |
6.9 μM
Compound: YCW-E11
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Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
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[PMID: 34228434] |
| RS4-11 | IC50 |
6.2 μM
Compound: YCW-E11
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Cytotoxicity against human RS4-11 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Cytotoxicity against human RS4-11 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
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[PMID: 34228434] |
Chemical Information
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No. CAS 1519043-97-0
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Peso molecular 594.49
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Fòrmula C25H21Cl2N3O6S2
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SMILES
O=C(NCCNS(=O)(C1=C(C2=C(OC3=CC=C(C(O)=C3)O)C=CC=C2)C=CS1)=O)NC4=CC(Cl)=CC(Cl)=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YCW-E11 Related Classifications
HY-116532 Related Classifications
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