YF438
YF438 is an HDAC inhibitor with effective anticancer activity both in vitro and in vivo. YF438 inhibits the growth and metastasis of triple-negative breast cancer (TNBC) cells by blocking the interaction between HDAC and MDM2, inducing the dissociation of MDM2-MDMX, and promoting the degradation of MDM2.
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- No. CAS: 2247210-09-7
- Fòrmula: C23H26N4O5
- Peso molecular:438.48
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCCLM3 | IC50 |
5.19 μM
Compound: 11a
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Antiproliferative activity against human HCCLM3 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCCLM3 cells after 48 hrs by MTT assay
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[PMID: 30455152] |
| HepG2 | IC50 |
1.07 μM
Compound: 11a
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Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
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[PMID: 30455152] |
Chemical Information
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No. CAS 2247210-09-7
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Peso molecular 438.48
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Fòrmula C23H26N4O5
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SMILES
O=C(CCCCCC(NO)=O)N(CC1=NOC(C2=CC=CC=C2)=N1)C3=CC=C(OC)C=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YF438 Related Classifications
HY-164550 Related Classifications
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