Nfatc1 - nuclear factor of activated T-cells 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 100361818

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and transcription coactivator binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human NFATC1 (nuclear factor of activated T cells 1). [provided by Alliance of Genome Resources, Apr 2022]

Nfatc1 Products (1)

mRNA Protein Name
NM_001244933.1 NP_001231862.1 nuclear factor of activated T-cells, cytoplasmic 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
14979875 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12557015 RGD
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
22566696 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
23110133 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
23110133 RGD
involved in mononuclear cell differentiation IEP
IEP: Inferred from expression pattern
23110133 RGD
involved in positive regulation of DNA biosynthetic process IMP
IMP: Inferred from mutant phenotype
18667424 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
14979875 RGD
involved in response to muscle activity IEP
IEP: Inferred from expression pattern
30907990 RGD
involved in skeletal muscle adaptation IEP
IEP: Inferred from expression pattern
24284598 RGD
involved in wound healing IMP
IMP: Inferred from mutant phenotype
18675800 RGD
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
14979875 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18675800 RGD
located in sarcoplasm IDA
IDA: Inferred from direct assay
30907990 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear factor of activated T-cells, cytoplasmic 1

  • nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-113756A Latanoprost acid Agonist 98.77% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-16275 Nivocasan Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (38)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0656 Usnic acid 99.40% Unkown
HY-N0481 Roburic acid 99.93% Unkown
HY-N0231 Bavachalcone 99.90% Unkown
HY-N2119 Sciadopitysin Inhibitor 99.0% Unkown
HY-B2162B Chondroitin sulfate sodium (from bovine) Inhibitor 99.40% Unkown
HY-147369 NFATc1-IN-1 Inhibitor 99.97% Unkown
HY-N0616 Trifolirhizin 98.37% Unkown
HY-N3312 Matairesinol Inhibitor 98.78% Unkown
HY-175232 GL64 Inhibitor 98.80% Unkown
HY-N0381 Maackiain 99.83% Unkown
HY-N5048 Galloylpaeoniflorin Inhibitor 98.30% Unkown
HY-N0026 2'-Acetylacteoside Inhibitor 99.73% Unkown
HY-N0805A Alisol B 99.57% Unkown
HY-W423191 Maltobionic acid Inhibitor 99.86% Unkown
HY-15001G Stemregenin 1 (GMP) Antagonist / Unkown
HY-165126 Schizophyllan / Unkown
HY-N2736 3′,4′,7-Trihydroxyflavone Inhibitor 99.04% Unkown
HY-N2157 Pteryxin Inhibitor 99.55% Unkown
HY-N0853A Alisol A 24-acetate 98.0% Unkown
HY-117200 Necrostatin-7 Inhibitor 99.64% Unkown
HY-182757 Y1693 Inhibitor 99.91% Unkown
HY-W641445 ELP-004 Inhibitor 99.89% Unkown
HY-123503 Salicortin Inhibitor / Unkown
HY-124958 NDMC101 Inhibitor 99.91% Unkown
HY-N2528 Usnic acid sodium Inhibitor / Unkown
HY-107614G 1-Oleoyl lysophosphatidic acid sodium (GMP) Activator / Unkown
HY-113756B rel-Latanoprost acid Agonist / Unkown
HY-116640 Amorphigenin Inhibitor / Unkown
HY-149852 Anti-osteoporosis agent-3 / Unkown
HY-162280 PROTAC BTK Degrader-9 / Unkown
HY-182818 SH494 / Unkown
HY-N3071 Picrasidine I / Unkown
HY-P11617 CLP-d2 Inhibitor / Unkown
HY-P4684 Osteostatin / Unkown
HY-RS09238 NFATC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W185542 E09241 / Unkown
HY-RS18427 Nfatc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24908 Nfatc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfatc1 NCBI NCBI:4772