AGR2 - anterior gradient 2, protein disulphide isomerase family member Gene

Homo sapiens

Also known as AG2; AG-2; HPC8; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116

Gene ID: 10551 | Gene type: protein coding

About AGR2

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:16,791,811-16,804,999 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 2 paralogues. Biased expression in stomach (RPKM 530.9), colon (RPKM 321.4) and 6 other tissues.

Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein Mucin. This gene has been implicated in inflammatory bowel disease and Cancer progression. [provided by RefSeq, Mar 2017]

AGR2 Products(1)

mRNA	Protein	Name
NM_006408.4	NP_006399.1	anterior gradient protein 2 homolog precursor

AGR2 Protein Structure

Thioredoxin_7

0
100
175 a.a.

Protein Preferred Names

Protein Names

anterior gradient protein 2 homolog

anterior gradient homolog 2

Recombinant AGR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7465	AG-2 Protein, Human (HEK293, His)	O95994 (R21-L175)	≥95%
HY-P7465A	AG-2 Protein, Human (HEK293, C-His)	O95994 (R21-L175)	≥95%

Related Diseases

Diseases

Alias

Ileocolitis

Iieocolitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Non-Proliferative Fibrocystic Change Of The Breast

Non-Proliferative Fibrocystic Change

Breast Fibrocystic Change, Non-Proliferative Type

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma	Fhcc
Fibrolamellar Hepatocarcinoma	Hepatocellular Carcinoma, Fibrolamellar
Oncocytic Hepatocellular Tumor	Eosinophilic Glassy Cell Hepatoma
Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis	Fl-Hcc
Fibrolamellar Oncocytic Hepatoma	Hepatocellular Carcinoma With Increased Stromal Fibrosis
Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00462	AGR2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AGR2	MGD	MGI:1344405
Bos taurus	AGR2	VGNC	VGNC:25740
Canis familiaris	AGR2	VGNC	VGNC:37715
Felis catus	AGR2	VGNC	VGNC:59690
Rattus norvegicus	AGR2	RGD	RGD:1304606
Macaca mulatta	AGR2	VGNC	VGNC:69748
Others	AGR2	NCBI