AGR2 - anterior gradient 2, protein disulphide isomerase family member Gene

Also Known as AG2; AG-2; HPC8; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10551

About AGR2

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:16,791,811-16,804,999 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 2 paralogues. Biased expression in stomach (RPKM 530.9), colon (RPKM 321.4) and 6 other tissues.

Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein Mucin. This gene has been implicated in inflammatory bowel disease and Cancer progression. [provided by RefSeq, Mar 2017]

AGR2 Products (1)

mRNA	Protein	Name
NM_006408.4	NP_006399.1	anterior gradient protein 2 homolog precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables dystroglycan binding	IDA IDA: Inferred from direct assay	12592373	GOA
enables epidermal growth factor receptor binding	IPI IPI: Inferred from physical interaction	25666625	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	23220234	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12592373	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of IRE1-mediated unfolded protein response	IDA IDA: Inferred from direct assay	23220234	GOA
involved in positive regulation of PERK-mediated unfolded protein response	IDA IDA: Inferred from direct assay	23220234	GOA
involved in positive regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	23274113	GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25666625	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22184114	GOA
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	25666625	GOA
NOT involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	25666625	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	22184114	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	15834940	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	22184114	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGR2 Protein Structure

Thioredoxin_7

0
100
175 a.a.

Protein Preferred Names	Protein Names
anterior gradient protein 2 homolog	anterior gradient homolog 2

AGR2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AGR2	O95994	CDKN2AIPNL	Homo sapiens	Q96HQ2	Validated Y2H	32296183
Intra	AGR2	O95994	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	AGR2	O95994	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Prey Pooling	25416956
Intra	AGR2	O95994	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	AGR2	O95994	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	AGR2	O95994	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	AGR2	O95994	CRYGA	Homo sapiens	Q24JT5	Validated Y2H	32296183
Intra	AGR2	O95994	ZDHHC24	Homo sapiens	Q6UX98	Validated Y2H	32296183
Intra	AGR2	O95994	LGALS14	Homo sapiens	Q8TCE9	Validated Y2H	32296183
Intra	AGR2	O95994	NSD1	Homo sapiens	Q96L73-2	Validated Y2H	32296183
Intra	AGR2	O95994	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	AGR2	O95994	ZNF410	Homo sapiens	Q86VK4-3	Validated Y2H	32296183
Intra	AGR2	O95994	NRF1	Homo sapiens	Q16656-4	Validated Y2H	32296183
Intra	AGR2	O95994	TFAP2D	Homo sapiens	Q7Z6R9	Validated Y2H	32296183
Intra	AGR2	O95994	POM121	Homo sapiens	Q96HA1-2	Validated Y2H	32296183
Intra	AGR2	O95994	PSORS1C2	Homo sapiens	Q9UIG4	Validated Y2H	32296183
Intra	AGR2	O95994	VEZF1	Homo sapiens	Q14119	Validated Y2H	32296183
Intra	AGR2	O95994	POU6F2	Homo sapiens	P78424	Validated Y2H	32296183
Intra	AGR2	O95994	ASPH	Homo sapiens	Q12797-6	Validated Y2H	32296183
Intra	AGR2	O95994	ASPH	Homo sapiens	Q12797-6	Y2H Prey Pooling	32296183
Intra	AGR2	O95994	CYB5R2	Homo sapiens	Q6BCY4-2	Validated Y2H	32296183
Intra	AGR2	O95994	RBFOX1	Homo sapiens	Q9NWB1-5	Validated Y2H	32296183
Intra	AGR2	O95994	RBFOX1	Homo sapiens	Q9NWB1-5	Y2H Prey Pooling	32296183
Intra	AGR2	O95994	RBFOX1	Homo sapiens	Q9NWB1-5	Y2H Array	32296183
Intra	AGR2	O95994	WUGSC:H_DJ0726N20.gs.b	Homo sapiens	Q9Y6T4	Validated Y2H	32296183
Intra	AGR2	O95994	PHC3	Homo sapiens	Q8NDX5-7	Validated Y2H	32296183
Intra	AGR2	O95994	TYK2	Homo sapiens	P29597	Validated Y2H	32296183
Intra	AGR2	O95994	ANKRD11	Homo sapiens	X5D778	Validated Y2H	32296183
Intra	AGR2	O95994	CAMLG	Homo sapiens	P49069	Validated Y2H	32296183
Intra	AGR2	O95994	FAM110A	Homo sapiens	Q9BQ89	Validated Y2H	32296183
Intra	AGR2	O95994	APOBEC3B	Homo sapiens	Q9UH17-2	Validated Y2H	32296183
Intra	AGR2	O95994	PTTG2	Homo sapiens	Q9NZH5-2	Validated Y2H	32296183
Intra	AGR2	O95994	THOC1	Homo sapiens	Q96FV9	Validated Y2H	32296183
Intra	AGR2	O95994	RTL4	Homo sapiens	Q6ZR62	Y2H Prey Pooling	32296183
Intra	AGR2	O95994	RTL4	Homo sapiens	Q6ZR62	Validated Y2H	32296183
Intra	AGR2	O95994	RTL4	Homo sapiens	Q6ZR62	Y2H Array	32296183
Intra	AGR2	O95994	MUC2	Homo sapiens	Q02817	Anti Tag CoIP	34237462
Intra	AGR2	O95994	DCAF11	Homo sapiens	Q8TEB1	Validated Y2H	32296183
Intra	AGR2	O95994	PRPF18	Homo sapiens	Q99633	Validated Y2H	32296183
Intra	AGR2	O95994	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32296183
Intra	AGR2	O95994	CD68	Homo sapiens	P34810	Validated Y2H	32296183
Intra	AGR2	O95994	CD34	Homo sapiens	P28906	Validated Y2H	32296183
Intra	AGR2	O95994	MYL6	Homo sapiens	P60660	Validated Y2H	32296183
Intra	AGR2	O95994	LSM1	Homo sapiens	O15116	Y2H Prey Pooling	32296183
Intra	AGR2	O95994	LSM1	Homo sapiens	O15116	Y2H Array	32296183
Intra	AGR2	O95994	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	AGR2	O95994	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	AGR2	O95994	IMPDH2	Homo sapiens	P12268	Validated Y2H	32296183
Intra	AGR2	O95994	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	AGR2	O95994	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	AGR2	O95994	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	AGR2	O95994	PSMA1	Homo sapiens	P25786	Validated Y2H	32296183
Intra	AGR2	O95994	POLR2L	Homo sapiens	P62875	Validated Y2H	32296183
Intra	AGR2	O95994	PSMB1	Homo sapiens	P20618	Validated Y2H	32296183
Intra	AGR2	O95994	FAM117B	Homo sapiens	Q6P1L5	Validated Y2H	32296183
Intra	AGR2	O95994	FABP2	Homo sapiens	P12104	Y2H Array	25416956
Intra	AGR2	O95994	HSD3B7	Homo sapiens	Q9H2F3	Validated Y2H	32296183
Intra	AGR2	O95994	RBP5	Homo sapiens	P82980	Validated Y2H	32296183
Intra	AGR2	O95994	GRB2	Homo sapiens	P62993	Validated Y2H	32296183
Intra	AGR2	O95994	IL36RN	Homo sapiens	Q9UBH0	Validated Y2H	32296183
Intra	AGR2	O95994	GABPB1	Homo sapiens	Q06547	Validated Y2H	32296183
Intra	AGR2	O95994	GTF2H5	Homo sapiens	Q6ZYL4	Validated Y2H	32296183
Intra	AGR2	O95994	KLHL38	Homo sapiens	Q2WGJ6	Validated Y2H	32296183
Intra	AGR2	O95994	GUCA1A	Homo sapiens	P43080	Validated Y2H	32296183
Intra	AGR2	O95994	TCEA2	Homo sapiens	Q15560	Validated Y2H	32296183
Intra	AGR2	O95994	CREB1	Homo sapiens	P16220	Validated Y2H	32296183
Intra	AGR2	O95994	POM121	Homo sapiens	Q96HA1	Validated Y2H	25416956
Intra	AGR2	O95994	POM121	Homo sapiens	Q96HA1	Y2H Array	25416956
Intra	AGR2	O95994	POM121	Homo sapiens	Q96HA1	Y2H Prey Pooling	25416956
Intra	AGR2	O95994	GTPBP3	Homo sapiens	Q969Y2	Validated Y2H	32296183
Intra	AGR2	O95994	HMG20A	Homo sapiens	Q9NP66	Y2H Prey Pooling	32296183
Intra	AGR2	O95994	HMG20A	Homo sapiens	Q9NP66	Y2H Array	32296183
Intra	AGR2	O95994	HMG20A	Homo sapiens	Q9NP66	Validated Y2H	32296183
Intra	AGR2	O95994	CNNM3	Homo sapiens	Q8NE01	Validated Y2H	32296183
Intra	AGR2	O95994	NUP54	Homo sapiens	Q7Z3B4	Validated Y2H	32296183
Intra	AGR2	O95994	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	AGR2	O95994	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	AGR2	O95994	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	AGR2	O95994	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	25416956
Intra	AGR2	O95994	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	AGR2	O95994	BORCS8	Homo sapiens	Q96FH0	Validated Y2H	32296183
Intra	AGR2	O95994	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	AGR2	O95994	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	AGR2	O95994	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	AGR2	O95994	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	25416956
Intra	AGR2	O95994	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	32296183
Intra	AGR2	O95994	NUP62CL	Homo sapiens	Q9H1M0	Validated Y2H	32296183
Intra	AGR2	O95994	NUP62CL	Homo sapiens	Q9H1M0	Y2H Array	25416956
Intra	AGR2	O95994	NUP62CL	Homo sapiens	Q9H1M0	Y2H Prey Pooling	25416956
Intra	AGR2	O95994	NUP62CL	Homo sapiens	Q9H1M0	Validated Y2H	25416956
Intra	AGR2	O95994	TSTD2	Homo sapiens	Q5T7W7	Validated Y2H	32296183
Intra	AGR2	O95994	C3	Homo sapiens	P01024	Validated Y2H	32296183
Intra	AGR2	O95994	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	AGR2	O95994	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	AGR2	O95994	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	AGR2	O95994	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	AGR2	O95994	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	AGR2	O95994	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	AGR2	O95994	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	AGR2	O95994	HCK	Homo sapiens	P08631-2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AGR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7465	AG-2 Protein, Human (HEK293, His, solution)	O95994 (R21-L175)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7465A	AG-2 Protein, Human (HEK293, His)	O95994 (R21-L175)	≥ 90%, as determined by reducing SDS-PAGE.

AGR2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82034	Anterior Gradient 2 Antibody (YA1779)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Rat
HY-P82034A	Anterior Gradient 2 Antibody (YA1779)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Rat
HY-P83880	Anterior Gradient 2 Antibody (YA3577)	ICC/IF, FC, ELISA	Human
HY-P83880A	Anterior Gradient 2 Antibody (YA3577)(PBS only)	ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Ileocolitis	Iieocolitis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Non-Proliferative Fibrocystic Change Of The Breast	Non-Proliferative Fibrocystic Change Breast Fibrocystic Change, Non-Proliferative Type
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Fibrolamellar Carcinoma	Fibrolamellar Hepatocellular Carcinoma Fhcc Fibrolamellar Hepatocarcinoma Hepatocellular Carcinoma, Fibrolamellar Oncocytic Hepatocellular Tumor Eosinophilic Glassy Cell Hepatoma Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis Fl-Hcc Fibrolamellar Oncocytic Hepatoma Hepatocellular Carcinoma With Increased Stromal Fibrosis Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P5831	Biotin-H10	Inhibitor	98.94%	Unkown
HY-RS00462	AGR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17048	Agr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23492	Agr2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992187	Anti-AGR2 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AGR2	MGD	MGI:1344405
Bos taurus	AGR2	VGNC	VGNC:25740
Canis familiaris	AGR2	VGNC	VGNC:37715
Felis catus	AGR2	VGNC	VGNC:59690
Rattus norvegicus	AGR2	RGD	RGD:1304606
Macaca mulatta	AGR2	VGNC	VGNC:69748
Others	AGR2	NCBI