Nsd2 - nuclear receptor binding SET domain protein 2 Gene

Also Known as MMSET; Whsc1; Whsc1l; mKIAA1090; 5830445G22Rik; 9430010A17Rik; C130020C13Rik; D030027O06Rik; D930023B08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107823

Summary

Enables chromatin binding activity; histone-lysine N-methyltransferase activity; and sequence-specific DNA binding activity. Acts upstream of or within several processes, including cardiac septum morphogenesis; histone lysine methylation; and regulation of nucleobase-containing compound metabolic process. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study Wolf-Hirschhorn syndrome. Human ortholog(s) of this gene implicated in Wolf-Hirschhorn syndrome. Orthologous to human NSD2 (nuclear receptor binding SET domain protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Nsd2 Products (3)

mRNA Protein Name
NM_001081102.2 NP_001074571.2 histone-lysine N-methyltransferase NSD2 isoform 1
NM_001177884.1 NP_001171355.1 histone-lysine N-methyltransferase NSD2 isoform 3
NM_175231.2 NP_780440.2 histone-lysine N-methyltransferase NSD2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
19483677 MGI
enables histone H3K36 trimethyltransferase activity IDA
IDA: Inferred from direct assay
19483677 MGI
enables histone methyltransferase activity IDA
IDA: Inferred from direct assay
19483677 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19483677 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23241889 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within atrial septum primum morphogenesis IMP
IMP: Inferred from mutant phenotype
19483677 MGI
acts upstream of or within atrial septum secundum morphogenesis IMP
IMP: Inferred from mutant phenotype
19483677 MGI
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
19483677 MGI
acts upstream of or within membranous septum morphogenesis IMP
IMP: Inferred from mutant phenotype
19483677 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19483677 MGI
acts upstream of or within positive regulation of isotype switching to IgA isotypes IMP
IMP: Inferred from mutant phenotype
23241889 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
23241889 MGI
acts upstream of or within regulation of double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
23241889 MGI
acts upstream of or within regulation of establishment of protein localization IMP
IMP: Inferred from mutant phenotype
23241889 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
19483677 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase NSD2

  • IL5 promoter REII region-binding protein

  • multiple myeloma SET domain-containing protein

  • nuclear SET domain-containing protein 2

  • probable histone-lysine N-methyltransferase NSD2

  • trithorax/ash1-related protein 5

  • wolf-Hirschhorn syndrome candidate 1 pro

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (48)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-154812 Gintemetostat Inhibitor 99.81% Unkown
HY-100034 NSC 663284 Inhibitor 99.29% Unkown
HY-161574 LLC0424 Inhibitor 98.41% Unkown
HY-114208A BI-9321 trihydrochloride Antagonist 99.83% Unkown
HY-157251 UNC8153 TFA Degrader 99.92% Unkown
HY-145103 UNC6934 Antagonist 98.24% Unkown
HY-114340 LEM-14 98.02% Unkown
HY-138283 MR837 Inhibitor 99.65% Unkown
HY-151101 MS159 Degrader 99.38% Unkown
HY-168035 W4275 Inhibitor 98.93% Unkown
HY-147914 NSD2-IN-1 Inducer 98.72% Unkown
HY-162308 NSD-IN-3 98.0% Unkown
HY-171119 NSD2-PWWP1-IN-1 Inhibitor 98.72% Unkown
HY-125244 LEM-14-1189 Inhibitor 99.76% Unkown
HY-171120 NSD2-PWWP1-IN-2 Inhibitor 99.64% Unkown
HY-171121 NSD2-PWWP1-IN-3 Inhibitor 99.63% Unkown
HY-138993A NNMT-IN-6 hydrochloride Inhibitor 99.75% Unkown
HY-15647 BRD9539 Inhibitor 99.73% Unkown
HY-157251A UNC8153 Degrader 99.61% Unkown
HY-161575 NSD2 ligand 1 99.76% Unkown
HY-161796 UNC8732 / Unkown
HY-161796A UNC8732 TFA Inhibitor 99.07% Unkown
HY-177499 NSD2-IN-5 Inhibitor 98.68% Unkown
HY-185557 LLC0424N / Unkown
HY-178321 UNC10088 Degrader / Unkown
HY-W1005059 N-Methylthalidomide 98.0% Unkown
HY-114208 BI-9321 Antagonist / Unkown
HY-124699 MMSET-IN-1 Inhibitor / Unkown
HY-138993 NNMT-IN-6 Inhibitor / Unkown
HY-155817 UNC7096 Chemical / Unkown
HY-155818 NSD2-IN-4 Inhibitor / Unkown
HY-161576 Thalidomide-Pip-N-boc / Unkown
HY-161670 NSD2-PWWP1 ligand 1 Inhibitor / Unkown
HY-170674 ND-L11B free base Degrader / Unkown
HY-170674A ND-L11B TFA Degrader / Unkown
HY-172614 RK-0080552 / Unkown
HY-175871 (Rac)-NSD2-PWWP1-IN-4 Inhibitor / Unkown
HY-177400 NSD-IN-5 Inhibitor / Unkown
HY-178322 UNC10415667 Degrader / Unkown
HY-179427 NSD2/H3K36me2 modulator-1 / Unkown
HY-179650 NSD2-PWWP1-IN-5 / Unkown
HY-179651 NSD2-PWWP1-IN-6 Inhibitor / Unkown
HY-180553 NSD2-IN-6 Inhibitor / Unkown
HY-182486 LEM-06 Inhibitor / Unkown
HY-RS09588 NSD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-48149 NSD2 ligand 2 Degrader 98.75% Unkown
HY-RS16731 Nsd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23167 Nsd2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nsd2 NCBI NCBI:7468