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Cat. No.: HY-155818

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NSD2-IN-4

NSD2-IN-4 is a potent and selective NSD2-SET inhibitor. NSD2-IN-4 has the potential for NSD2-related diseases.

For research use only. We do not sell to patients.

CAS No.: 3035028-80-6
Formula: C₁₈H₁₄ClN₃O₃
Molecular Weight:355.78

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

NSD2-IN-4 Chemical Structure

CAS No.: 3035028-80-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

NSD2-IN-4 is a potent and selective NSD2-SET inhibitor. NSD2-IN-4 has the potential for NSD2-related diseases^[1].

All Histone Methyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CMK	IC₅₀	2.6 μM Compound: 15a	Antiproliferative activity against human CMK cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay Antiproliferative activity against human CMK cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay	[PMID: 36642961]
Daudi	IC₅₀	12.8 μM Compound: 15a	Antiproliferative activity against human Daudi cells assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay Antiproliferative activity against human Daudi cells assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay	[PMID: 36642961]
HL-60	IC₅₀	2.66 μM Compound: 15a	Antiproliferative activity against human HL-60 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay Antiproliferative activity against human HL-60 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay	[PMID: 36642961]
KMS-11	IC₅₀	0.27 μM Compound: 15a	Antiproliferative activity against human KMS-11 cells assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay Antiproliferative activity against human KMS-11 cells assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay	[PMID: 36642961]
MOLM-13	IC₅₀	3.17 μM Compound: 15a	Antiproliferative activity against human MOLM-13 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay Antiproliferative activity against human MOLM-13 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay	[PMID: 36642961]
MOLT-4	IC₅₀	1.23 μM Compound: 15a	Antiproliferative activity against human MOLT-4 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay Antiproliferative activity against human MOLT-4 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay	[PMID: 36642961]
OCI-AML2	IC₅₀	2.6 μM Compound: 15a	Antiproliferative activity against human OCI-AML2 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay Antiproliferative activity against human OCI-AML2 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay	[PMID: 36642961]
OPM-2	IC₅₀	2.09 μM Compound: 15a	Antiproliferative activity against NSD2 translocated human OPM-2 cells assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay Antiproliferative activity against NSD2 translocated human OPM-2 cells assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay	[PMID: 36642961]
RS4-11	IC₅₀	0.304 μM Compound: 15a	Antiproliferative activity against human RS4-11 cells harboring NSD2 E1099K mutant assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay Antiproliferative activity against human RS4-11 cells harboring NSD2 E1099K mutant assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay	[PMID: 36642961]
THP-1	IC₅₀	2.64 μM Compound: 15a	Antiproliferative activity against human THP-1 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay Antiproliferative activity against human THP-1 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay	[PMID: 36642961]
U2932	IC₅₀	9.11 μM Compound: 15a	Antiproliferative activity against human U2932 cells assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay Antiproliferative activity against human U2932 cells assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay	[PMID: 36642961]
U-937	IC₅₀	4.9 μM Compound: 15a	Antiproliferative activity against human U-937 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay Antiproliferative activity against human U-937 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay	[PMID: 36642961]

Chemical Information

CAS No. 3035028-80-6
Molecular Weight 355.78
Formula C₁₈H₁₄ClN₃O₃
SMILES

O=C1C(NC2(C3)CC3(NC(C#CC)=O)C2)=C(Cl)C(C4=NC=CC=C41)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zonghui Ma, et al. Drug Discovery Targeting Nuclear Receptor Binding SET Domain Protein 2 (NSD2. J Med Chem. 2023 Aug 24;66(16):10991-11026 [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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