2. Epigenetics
  3. Histone Methyltransferase
  4. NSD2-IN-4

NSD2-IN-4 is a potent and selective NSD2-SET inhibitor. NSD2-IN-4 has the potential for NSD2-related diseases.

For research use only. We do not sell to patients.

NSD2-IN-4

NSD2-IN-4 Chemical Structure

CAS No. : 3035028-80-6

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NSD2-IN-4 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NSD2-IN-4 is a potent and selective NSD2-SET inhibitor. NSD2-IN-4 has the potential for NSD2-related diseases[1].

Cellular Effect
Cell Line Type Value Description References
CMK IC50
2.6 μM
Compound: 15a
Antiproliferative activity against human CMK cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
Antiproliferative activity against human CMK cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
[PMID: 36642961]
Daudi IC50
12.8 μM
Compound: 15a
Antiproliferative activity against human Daudi cells assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
Antiproliferative activity against human Daudi cells assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
[PMID: 36642961]
HL-60 IC50
2.66 μM
Compound: 15a
Antiproliferative activity against human HL-60 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
Antiproliferative activity against human HL-60 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
[PMID: 36642961]
KMS-11 IC50
0.27 μM
Compound: 15a
Antiproliferative activity against human KMS-11 cells assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
Antiproliferative activity against human KMS-11 cells assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
[PMID: 36642961]
MOLM-13 IC50
3.17 μM
Compound: 15a
Antiproliferative activity against human MOLM-13 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
Antiproliferative activity against human MOLM-13 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
[PMID: 36642961]
MOLT-4 IC50
1.23 μM
Compound: 15a
Antiproliferative activity against human MOLT-4 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
Antiproliferative activity against human MOLT-4 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
[PMID: 36642961]
OCI-AML2 IC50
2.6 μM
Compound: 15a
Antiproliferative activity against human OCI-AML2 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
Antiproliferative activity against human OCI-AML2 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
[PMID: 36642961]
OPM-2 IC50
2.09 μM
Compound: 15a
Antiproliferative activity against NSD2 translocated human OPM-2 cells assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
Antiproliferative activity against NSD2 translocated human OPM-2 cells assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
[PMID: 36642961]
RS4-11 IC50
0.304 μM
Compound: 15a
Antiproliferative activity against human RS4-11 cells harboring NSD2 E1099K mutant assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
Antiproliferative activity against human RS4-11 cells harboring NSD2 E1099K mutant assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
[PMID: 36642961]
THP-1 IC50
2.64 μM
Compound: 15a
Antiproliferative activity against human THP-1 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
Antiproliferative activity against human THP-1 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
[PMID: 36642961]
U-937 IC50
4.9 μM
Compound: 15a
Antiproliferative activity against human U-937 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
Antiproliferative activity against human U-937 cells harboring wild type NSD2 assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
[PMID: 36642961]
U2932 IC50
9.11 μM
Compound: 15a
Antiproliferative activity against human U2932 cells assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
Antiproliferative activity against human U2932 cells assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
[PMID: 36642961]
Molecular Weight

355.78

Formula

C18H14ClN3O3
CAS No.
SMILES

O=C1C(NC2(C3)CC3(NC(C#CC)=O)C2)=C(Cl)C(C4=NC=CC=C41)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NSD2-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSD2-IN-43035028-80-6Histone MethyltransferaseInhibitorinhibitorinhibit

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HY-155818
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