Atm - ataxia telangiectasia mutated Gene

Also Known as C030026E19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11920

About Atm

Chromosome 9: 53,350,449-53,448,040 reverse strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 226 orthologues, 5 paralogues and is associated with 130 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 3.8), CNS E14 (RPKM 2.7) and 24 other tissues.

Summary

Enables protein kinase activity. Involved in several processes, including cellular response to retinoic acid; negative regulation of TORC1 signaling; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including DNA recombination; animal organ development; and meiotic nuclear division. Located in cytoplasm; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Used to study ataxia telangiectasia. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; endometrial cancer; lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Atm Products (1)

mRNA Protein Name
NM_007499.3 NP_031525.3 serine-protein kinase ATM

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone H2AXS139 kinase activity IDA
IDA: Inferred from direct assay
11571274 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15680327 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
10710310 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
12937170 MGI
acts upstream of or within DNA damage response IGI
IGI: Inferred from genetic interaction
19061978 MGI
acts upstream of or within DNA repair IDA
IDA: Inferred from direct assay
15364958 MGI
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
11679583 MGI
acts upstream of or within V(D)J recombination IGI
IGI: Inferred from genetic interaction
23836881 MGI
acts upstream of or within brain development IGI
IGI: Inferred from genetic interaction
16687486 MGI
involved in cellular response to retinoic acid IMP
IMP: Inferred from mutant phenotype
20876357 MGI
acts upstream of or within chromosome organization involved in meiotic cell cycle IMP
IMP: Inferred from mutant phenotype
8843194 MGI
acts upstream of or within determination of adult lifespan IGI
IGI: Inferred from genetic interaction
19061978 MGI
acts upstream of or within double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
19061978 MGI
acts upstream of or within female gamete generation IMP
IMP: Inferred from mutant phenotype
15640358 MGI
acts upstream of or within female gonad development IMP
IMP: Inferred from mutant phenotype
8843194 MGI
acts upstream of or within female meiotic nuclear division IMP
IMP: Inferred from mutant phenotype
8843194 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
16687486 MGI
acts upstream of or within immune system process IMP
IMP: Inferred from mutant phenotype
8843194 MGI
acts upstream of or within immunoglobulin production IMP
IMP: Inferred from mutant phenotype
8843194 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IGI
IGI: Inferred from genetic interaction
17476307 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
11040211 MGI
acts upstream of or within lipoprotein catabolic process IGI
IGI: Inferred from genetic interaction
15863839 MGI
acts upstream of or within male meiotic nuclear division IMP
IMP: Inferred from mutant phenotype
8843194 MGI
acts upstream of or within meiotic telomere clustering IMP
IMP: Inferred from mutant phenotype
17010969 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
8843194 MGI
involved in negative regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
23878245 MGI
acts upstream of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
10639175 MGI
acts upstream of or within neuron apoptotic process IGI
IGI: Inferred from genetic interaction
11248063 MGI
acts upstream of or within oocyte development IMP
IMP: Inferred from mutant phenotype
11536012 MGI
acts upstream of or within ovarian follicle development IMP
IMP: Inferred from mutant phenotype
8843194 MGI
involved in positive regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
20876357 MGI
acts upstream of or within positive regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
10639175 MGI
involved in positive regulation of telomere maintenance via telomerase IMP
IMP: Inferred from mutant phenotype
26586427 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20876357 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
8843194 MGI
involved in pre-B cell allelic exclusion IMP
IMP: Inferred from mutant phenotype
19448632 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
15364958 MGI
involved in regulation of autophagy IMP
IMP: Inferred from mutant phenotype
23878245 MGI
acts upstream of or within response to ionizing radiation IGI
IGI: Inferred from genetic interaction
10639175 MGI
acts upstream of or within somitogenesis IGI
IGI: Inferred from genetic interaction
16687486 MGI
acts upstream of or within thymus development IMP
IMP: Inferred from mutant phenotype
8843194 MGI
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
25936915 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
29955025 MGI
is active in extrinsic component of synaptic vesicle membrane IDA
IDA: Inferred from direct assay
27075534 MGI
located in nucleus IDA
IDA: Inferred from direct assay
29955025 MGI
located in spindle IDA
IDA: Inferred from direct assay
15509711 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Atm Protein Structure

TAN

TAN: pfam11640 (7 - 164)

FAT

FAT: pfam02259 (2101 - 2495)

PIKKc_ATM

PIKKc_ATM: cd05171 (2689 - 2968)

FATC

FATC: pfam02260 (3032 - 3061)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2500
  • 3063 a.a.
Protein Preferred Names Protein Names

serine-protein kinase ATM

  • A-T mutated homolog

  • ataxia telangiectasia gene mutated in human beings

  • ataxia telangiectasia mutated homolog

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-109566 AZD1390 Inhibitor 99.22% Phase 3
HY-13902 Berzosertib Inhibitor 99.67% Phase 2
HY-139609 Camonsertib Inhibitor 99.99% Phase 2
HY-150617 Lartesertib Inhibitor 99.94% Phase 2
HY-111783G AZD-7648 (GMP) Inhibitor / Phase 2
HY-100016 AZD0156 Inhibitor 99.83% Phase 1

Pre-clinical Phase

Bioactive Molecules (26)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111783 AZD-7648 Inhibitor 99.86% Unkown
HY-12016 KU-55933 Inhibitor 99.92% Unkown
HY-14731 VE-821 Inhibitor 99.67% Unkown
HY-12061 KU-60019 Inhibitor 99.43% Unkown
HY-15520 CGK733 Inhibitor 99.71% Unkown
HY-15521 ETP-46464 Inhibitor 99.54% Unkown
HY-103241 Ro 90-7501 Inhibitor 98.50% Unkown
HY-11002 CP-466722 Inhibitor 99.74% Unkown
HY-112198 AZ31 Inhibitor 98.22% Unkown
HY-112305 AZ32 Inhibitor 99.81% Unkown
HY-158345 PROTAC ATM degrader-1 Degrader 98.01% Unkown
HY-112614 ATM Inhibitor-1 Inhibitor / Unkown
HY-174828 ATR/PARP1-IN-1 Inhibitor / Unkown
HY-144686 ATM Inhibitor-3 Inhibitor / Unkown
HY-169310 ATM Inhibitor-11 Inhibitor / Unkown
HY-172247 ATR-IN-31 Inhibitor / Unkown
HY-144687 ATM Inhibitor-4 Inhibitor / Unkown
HY-13902A Berzosertib hydrochloride Inhibitor 98.77% Unkown
HY-144685 ATM Inhibitor-2 Inhibitor / Unkown
HY-147567 ATR-IN-15 Inhibitor / Unkown
HY-174989 ATM-IN-2 Inhibitor / Unkown
HY-149291 ATM Inhibitor-7 Inhibitor / Unkown
HY-141478 Antitumor agent-28 Inhibitor / Unkown
HY-151915 ATR-IN-20 Inhibitor / Unkown
HY-185575 ATM ligand-1 Ligand / Unkown
HY-N18301 Americanin A Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atm NCBI NCBI:472