2. Gene
  3. Atm - ataxia telangiectasia mutated Gene

Atm - ataxia telangiectasia mutated Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as C030026E19Rik

Gene ID: 11920 | Gene type: protein coding

About Atm

Chromosome 9: 53,350,449-53,448,040 reverse strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 226 orthologues, 5 paralogues and is associated with 130 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 3.8), CNS E14 (RPKM 2.7) and 24 other tissues.

Summary

Enables protein kinase activity. Involved in several processes, including cellular response to retinoic acid; negative regulation of TORC1 signaling; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including DNA recombination; animal organ development; and meiotic nuclear division. Located in cytoplasm; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Used to study ataxia telangiectasia. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; endometrial cancer; lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Atm Products(1)

mRNA Protein Name
NM_007499.3 NP_031525.3 serine-protein kinase ATM

Atm Protein Structure

TAN

TAN: pfam11640 (7 - 164)

FAT

FAT: pfam02259 (2101 - 2495)

PIKKc_ATM

PIKKc_ATM: cd05171 (2689 - 2968)

FATC

FATC: pfam02260 (3032 - 3061)

  • 0
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  • 2500
  • 3063 a.a.
Protein Preferred Names Protein Names

serine-protein kinase ATM

A-T mutated homolog

ataxia telangiectasia gene mutated in human beings

ataxia telangiectasia mutated homolog

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-111783 AZD-7648 Inhibitor 99.86% Phase 2
HY-139609 Camonsertib Inhibitor 99.75% Phase 2
HY-109566 AZD1390 Inhibitor 99.28% Phase 1
HY-100016 AZD0156 Inhibitor 99.82% Phase 1
Pre-clinical Phase
Bioactive Molecules (19)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12016 KU-55933 Inhibitor 99.88% Unkown
HY-12061 KU-60019 Inhibitor 99.43% Unkown
HY-14731 VE-821 Inhibitor 98.32% Unkown
HY-13902 Berzosertib Inhibitor 99.70% Unkown
HY-150617 Lartesertib Inhibitor 99.89% Unkown
HY-11002 CP-466722 Inhibitor 99.91% Unkown
HY-15520 CGK733 Inhibitor 99.83% Unkown
HY-103241 Ro 90-7501 Inhibitor 99.10% Unkown
HY-112305 AZ32 Inhibitor 99.94% Unkown
HY-15521 ETP-46464 Inhibitor 99.55% Unkown
HY-112198 AZ31 Inhibitor 98.13% Unkown
HY-112614 ATM Inhibitor-1 Inhibitor / Unkown
HY-144685 ATM Inhibitor-2 Inhibitor / Unkown
HY-144687 ATM Inhibitor-4 Inhibitor / Unkown
HY-144686 ATM Inhibitor-3 Inhibitor / Unkown
HY-141478 Antitumor agent-28 Inhibitor / Unkown
HY-151915 ATR-IN-20 Inhibitor / Unkown
HY-147567 ATR-IN-15 Inhibitor / Unkown
HY-149291 A011 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atm NCBI NCBI:472