Cyp1b1 - cytochrome P450, family 1, subfamily b, polypeptide 1 Gene

Also Known as CP1B; CYPIB1; P4501b1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13078

Summary

Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including camera-type eye development; cellular response to oxidative stress; and retinoid metabolic process. Acts upstream of or within several processes, including endothelial cell-cell adhesion; toxin metabolic process; and vasculature development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; musculature; nervous system; and sensory organ. Used to study buphthalmos. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Orthologous to human CYP1B1 (Cytochrome P450 family 1 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp1b1 Products (2)

mRNA Protein Name
NM_001364889.1 NP_001351818.1 cytochrome P450 1B1 isoform 2
NM_009994.2 NP_034124.1 cytochrome P450 1B1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables monooxygenase activity IDA
IDA: Inferred from direct assay
15258110 MGI
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA
IDA: Inferred from direct assay
9367523 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
19005183 MGI
involved in arachidonate metabolic process IDA
IDA: Inferred from direct assay
15258110 MGI
acts upstream of or within benzene-containing compound metabolic process IDA
IDA: Inferred from direct assay
1910294 MGI
acts upstream of or within benzene-containing compound metabolic process IMP
IMP: Inferred from mutant phenotype
9367523 MGI
acts upstream of or within blood vessel endothelial cell migration IMP
IMP: Inferred from mutant phenotype
19005183 MGI
involved in blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
23568032 MGI
involved in cell adhesion IMP
IMP: Inferred from mutant phenotype
23979599 MGI
involved in cellular response to hydrogen peroxide IMP
IMP: Inferred from mutant phenotype
23979599 MGI
involved in collagen fibril organization IMP
IMP: Inferred from mutant phenotype
23979599 MGI
NOT acts upstream of or within dibenzo-p-dioxin metabolic process IMP
IMP: Inferred from mutant phenotype
16636061 MGI
involved in endothelial cell migration IMP
IMP: Inferred from mutant phenotype
20032512 MGI
acts upstream of or within endothelial cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
19005183 MGI
involved in estrogen metabolic process IDA
IDA: Inferred from direct assay
23821647 MGI
involved in intrinsic apoptotic signaling pathway in response to oxidative stress IMP
IMP: Inferred from mutant phenotype
23568032 MGI
involved in membrane lipid catabolic process IMP
IMP: Inferred from mutant phenotype
19005183 MGI
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
23568032 MGI
involved in negative regulation of cell adhesion mediated by integrin IMP
IMP: Inferred from mutant phenotype
23568032 MGI
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
23568032 MGI
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
23568032 MGI
involved in nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
20032512 MGI
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
20032512 MGI
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
23568032 MGI
involved in positive regulation of receptor signaling pathway via JAK-STAT IMP
IMP: Inferred from mutant phenotype
23568032 MGI
involved in positive regulation of vascular endothelial growth factor production IMP
IMP: Inferred from mutant phenotype
23568032 MGI
involved in regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
19005183 MGI
acts upstream of or within response to toxic substance IMP
IMP: Inferred from mutant phenotype
16377763 MGI
acts upstream of or within retina vasculature development in camera-type eye IMP
IMP: Inferred from mutant phenotype
19005183 MGI
involved in retinal blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
20032512 MGI
involved in retinal metabolic process IDA
IDA: Inferred from direct assay
15258110 MGI
involved in retinol metabolic process IDA
IDA: Inferred from direct assay
15258110 MGI
acts upstream of or within toxin metabolic process IMP
IMP: Inferred from mutant phenotype
10051580 MGI
involved in trabecular meshwork development IMP
IMP: Inferred from mutant phenotype
23979599 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IMP
IMP: Inferred from mutant phenotype
23692925 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytochrome P450 1B1

  • cytochrome P450, 1b1, benz[a]anthracene inducible

  • cytochrome P450CMEF

  • cytochrome P450EF

  • hydroperoxy icosatetraenoate dehydratase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1234 Octinoxate 99.84% Unkown
HY-W017113 2-Mercaptobenzothiazole 99.85% Yes

Pre-clinical Phase

Bioactive Molecules (41)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19340 TMS Inhibitor 99.40% Unkown
HY-133677 Mono(2-ethyl-5-hydroxyhexyl) phthalate 99.03% Unkown
HY-W007700 8-Bromooctanoic acid 99.89% Unkown
HY-101285 DMU2139 Inhibitor 98.0% Unkown
HY-152118 CYP1B1-IN-4 Inhibitor 99.09% Unkown
HY-124404 12(R)-HETE 99.90% Unkown
HY-N5132 (-)-Fenchone 98.0% Unkown
HY-159006 CYP1B1 ligand 3 Inhibitor 99.83% Unkown
HY-101284 DMU2105 Inhibitor 99.31% Unkown
HY-146393 PROTAC CYP1B1 degrader-1 Inhibitor 98.26% Unkown
HY-157942 CYP1B1-IN-7 Inhibitor 99.88% Unkown
HY-RS03443 CYP1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W713284 2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate 99.87% Unkown
HY-16676 7-Epi-docetaxel Activator 98.76% Unkown
HY-150557 CYP1B1-IN-1 Inhibitor / Unkown
HY-150558 CYP1B1-IN-2 Inhibitor / Unkown
HY-152079 CYP1B1-IN-3 Inhibitor / Unkown
HY-152196 CYP1B1-IN-5 Inhibitor 98.03% Unkown
HY-158429 PROTAC CYP1B1 degrader-2 / Unkown
HY-158430 CYP1B1 ligand 2 / Unkown
HY-161403 CYP1B1-IN-8 Inhibitor / Unkown
HY-162051 CYP1B1-IN-6 Inhibitor / Unkown
HY-174425 CYP1B1-IN-9 Inhibitor / Unkown
HY-175554 CYP1B1-IN-10 Inhibitor / Unkown
HY-175760 CYP1B1-IN-11 Inhibitor / Unkown
HY-175836 CYP1B1-IN-12 / Unkown
HY-178053 AHR agonist 10 / Unkown
HY-181550A CYP1B1-IN-14 TFA Inhibitor / Unkown
HY-181629 ZSTK3744 / Unkown
HY-181629A ZSTK3744 hydrochloride / Unkown
HY-183304 Anticancer agent 318 Substrate / Unkown
HY-187206 CYP1B1-IN-15 Inhibitor / Unkown
HY-101284A (E/Z)-DMU2105 Inhibitor / Unkown
HY-126308 (E/Z)-DMU2139 Inhibitor / Unkown
HY-158431 (S,R,S)-AHPC-Me-8-bromooctanoic acid / Unkown
HY-B1234S Octinoxate-13C,d3 / Unkown
HY-RS16945 Cyp1b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23388 Cyp1b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W472509 11-HETE Activator / Unkown
HY-W517092 1,2,3,4,7,8,9-Heptachlorodibenzofuran / Unkown
HY-W775354 1,2,3,4,7,8-Hexachlorodibenzofuran / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp1b1 NCBI NCBI:1545