Fasn - fatty acid synthase Gene

Also Known as FAS; A630082H08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14104

About Fasn

Chromosome 11: 120,696,672-120,715,373 reverse strand.GRCm39:CM001004.3

This gene has 6 transcripts (splice variants), 195 orthologues, 1 paralogue and is associated with 4 phenotypes. Biased expression in mammary gland adult (RPKM 165.), subcutaneous fat pad adult (RPKM 1125.4) and 6 other tissues.

Summary

Enables fatty acid synthase activity. Involved in ether lipid biosynthetic process; mammary gland development; and myeloid leukocyte differentiation. Acts upstream of or within cellular response to interleukin-4; epithelial cell development; and fatty acid biosynthetic process. Located in glycogen granule. Is expressed in several structures, including adipose tissue; alimentary system; nervous system; sensory organ; and skeleton. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Apr 2022]

Fasn Products (1)

mRNA Protein Name
NM_007988.3 NP_032014.3 fatty acid synthase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fatty acid synthase activity IDA
IDA: Inferred from direct assay
16054098 MGI
enables fatty acid synthase activity IMP
IMP: Inferred from mutant phenotype
16054078 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to interleukin-4 IDA
IDA: Inferred from direct assay
9798653 MGI
acts upstream of or within establishment of endothelial intestinal barrier IMP
IMP: Inferred from mutant phenotype
25565205 MGI
involved in ether lipid biosynthetic process IMP
IMP: Inferred from mutant phenotype
25565205 MGI
acts upstream of or within fatty acid biosynthetic process IDA
IDA: Inferred from direct assay
22331133 MGI
acts upstream of or within glandular epithelial cell development IMP
IMP: Inferred from mutant phenotype
25565205 MGI
acts upstream of inflammatory response IMP
IMP: Inferred from mutant phenotype
25565205 MGI
involved in lipid biosynthetic process IDA
IDA: Inferred from direct assay
16054098 MGI
involved in lipid biosynthetic process IMP
IMP: Inferred from mutant phenotype
16054078 MGI
involved in mammary gland development IMP
IMP: Inferred from mutant phenotype
24668799 MGI
involved in monocyte differentiation IMP
IMP: Inferred from mutant phenotype
25565205 MGI
involved in neutrophil differentiation IMP
IMP: Inferred from mutant phenotype
25565205 MGI
acts upstream of or within tissue development IMP
IMP: Inferred from mutant phenotype
25565205 MGI
Cellular Component GO Annotation Evidence References Source
located in glycogen granule IDA
IDA: Inferred from direct assay
15169678 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fasn Protein Structure

PksD

PksD: COG3321 (0 - 1014)

PKS

PKS: cd00833 (1 - 403)

Methyltransf_12

Methyltransf_12: pfam08242 (1238 - 1336)

KR_1_FAS_SDR_x

KR_1_FAS_SDR_x: cd08954 (1310 - 1517)

PKS_ER

PKS_ER: smart00829 (1556 - 1846)

KR_1_FAS_SDR_x

KR_1_FAS_SDR_x: cd08954 (1868 - 2104)

PKS_PP

PKS_PP: smart00823 (2117 - 2172)

Thioesterase

Thioesterase: pfam00975 (2234 - 2493)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2400
  • 2504 a.a.
Protein Preferred Names Protein Names

fatty acid synthase

  • type I Fatty Acid Synthase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0218 Orlistat 99.95% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112829 Denifanstat Inhibitor 99.58% Phase 3

Pre-clinical Phase

Bioactive Molecules (45)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12364 C75 99.91% Unkown
HY-A0210 Cerulenin ≥99.0% Unkown
HY-120394 TVB-3166 99.69% Unkown
HY-120062 TVB-3664 Inhibitor 99.76% Unkown
HY-12325 GSK2194069 Inhibitor 99.80% Unkown
HY-16100 BI 99179 Inhibitor 99.38% Unkown
HY-124628 IPI-9119 Inhibitor 98.91% Unkown
HY-121250 Fasnall 99.94% Unkown
HY-N3415 Kumatakenin 99.31% Unkown
HY-12364A trans-C75 Inhibitor 99.79% Unkown
HY-B0218R Orlistat (Standard) 98.21% Unkown
HY-111551 FT113 Inhibitor 99.39% Unkown
HY-116568 Prothioconazole 99.52% Unkown
HY-N2486 Desoxyrhaponticin 99.80% Unkown
HY-12648A FASN-IN-4 tosylate Inhibitor 98.55% Unkown
HY-110354 UCM05 Inhibitor 99.22% Unkown
HY-111777 FASN-IN-1 Inhibitor 99.69% Unkown
HY-N1399 Androsin 99.94% Unkown
HY-145809 FASN-IN-5 Inhibitor 99.98% Unkown
HY-117769 GSK837149A Inhibitor 99.13% Unkown
HY-B0218S Orlistat-d3 99.9% Unkown
HY-N12124 Monascuspiloin 95% Unkown
HY-12648 FASN-IN-4 Inhibitor 99.21% Unkown
HY-N8144 Niga-ichigoside F1 99.0% Unkown
HY-RS04753 FASN Human Pre-designed siRNA Set A / Unkown
HY-RS04754 Fasn Mouse Pre-designed siRNA Set A / Unkown
HY-RS04755 Fasn Rat Pre-designed siRNA Set A / Unkown
HY-U00436 FASN-IN-3 Inhibitor 98.06% Unkown
HY-W587772 Mono(2-ethyl-5-hydroxyhexyl) terephthalate 98.27% Unkown
HY-110354R UCM05 (Standard) Inhibitor / Unkown
HY-112522 HS79 Inhibitor / Unkown
HY-112522A HS80 Inhibitor / Unkown
HY-12364B (−)-C75 / Unkown
HY-149540 CTL-06 Inhibitor / Unkown
HY-149541 CTL-12 Inhibitor / Unkown
HY-155282 FASN-IN-6 Inhibitor / Unkown
HY-158649 Fasnall benzenesulfonate / Unkown
HY-15957 FASN-IN-7 Inhibitor / Unkown
HY-170570 PFM046 / Unkown
HY-175020 QNX-10 / Unkown
HY-176274 FASN/SCD-IN-1 / Unkown
HY-181801 FASN-IN-8 / Unkown
HY-182750 ACLY-IN-3 Inhibitor / Unkown
HY-182751 ACLY-IN-4 Inhibitor / Unkown
HY-N17737 Floramanoside F / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fasn NCBI NCBI:2194