FASN - fatty acid synthase Gene

Also Known as FAS; OA-519; SDR27X1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2194

About FASN

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,078,338-82,098,236 (from NCBI)

This gene has 13 transcripts (splice variants), 195 orthologues, 1 paralogue and is associated with 1 phenotype. Biased expression in fat (RPKM 227.7), prostate (RPKM 28.4) and 3 other tissues.

Summary

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some Cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]

FASN Products (2)

mRNA	Protein	Name
NM_004104.5	NP_004095.4	fatty acid synthase
XM_011523538.3	XP_011521840.1	fatty acid synthase isoform X1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables [acyl-carrier-protein] S-acetyltransferase activity	IDA IDA: Inferred from direct assay	8962082	GOA
enables fatty acid synthase activity	EXP EXP: Inferred from Experiment	18455495	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18022563	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in modulation by host of viral process	IDA IDA: Inferred from direct assay	34320401	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FASN Protein Structure

ketoacyl-synt

Ketoacyl-synt_C

Acyl_transf_1

PS-DH

Methyltransf_12

ADH_zinc_N

PP-binding

Thioesterase

0
400
800
1200
1600
2000
2400
2511 a.a.

Protein Preferred Names	Protein Names
fatty acid synthase	3-hydroxyacyl-[acyl-carrier-protein] dehydratase 3-oxoacyl-[acyl-carrier-protein] reductase 3-oxoacyl-[acyl-carrier-protein] synthase Acyl-[acyl-carrier-protein] hydrolase Enoyl-[acyl-carrier-protein] reductase [Acyl-carrier-protein] S-acetyltransferase [Acyl-carrier-protein] S-malonyltransferase short chain dehydrogenase/reductase family 27X, member 1 type I fatty acid synthase

FASN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FASN	P49327	ADIPOQ	Homo sapiens	Q15848	Validated Y2H	32296183
Intra	FASN	P49327	HIF1A	Homo sapiens	Q16665	Anti Bait CoIP	36604718
Intra	FASN	P49327	HIF1A	Homo sapiens	Q16665	IF	36604718
Intra	FASN	P49327	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Cross	FASN	P49327	Q99IB8-PRO_0000045603	Hepatitis C virus	Q99IB8-PRO_0000045603	Anti Bait CoIP	23427160

Cross: Cross-species interaction Intra: Intraspecies interaction

FASN Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80128	Fatty Acid Synthase Antibody (YA444)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse, Rat
HY-P80668	Fatty Acid Synthase Antibody (YA766)	WB, ICC/IF, IP	Human, Mouse, Rat, Monkey
HY-P80668A	Fatty Acid Synthase Antibody (YA766)(PBS only)	WB, ICC/IF, IP	Human, Mouse, Rat, Monkey
HY-P85497	Fatty Acid Synthase Antibody (YA5189)	WB, IP, ICC/IF	Human, Mouse, Rat, Monkey, Bovine
HY-P86362	Fatty Acid Synthase Antibody (YA6054)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hyperinsulinism	Hyperinsulinemia
Lipid Storage Disease	Lipoidosis Inborn Lipid Storage Disorder Lipoid Storage Diseas Lipid Storage Diseases Lipidoses
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Diabetes Mellitus	Diabetes
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Non-Alcoholic Steatohepatitis	Nonalcoholic Steatohepatitis Nash Nash - [Non-Alcoholic Steatohepatitis] Non-Alcoholic Steatohepatosis
Fatty Liver Disease	Alcoholic Fatty Liver Fatty Liver Fatty Liver, Alcoholic Fatty Change Of Liver Hepatic Lipidosis Steatosis Of Liver Fatty Liver Alcoholic Steatohepatitis Etoh Fatty Liver Etoh Fatty Liver Metamorphosis Fatty Etoh Liver Necrosis
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Glucose Intolerance	Glucose: Intolerance Glucose: Malabsorption Malabsorption Of Glucose Impaired Glucose Tolerance

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0218	Orlistat		99.95%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112829	Denifanstat	Inhibitor	99.58%	Phase 3

Pre-clinical Phase

Bioactive Molecules (45)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12364	C75		99.91%	Unkown
HY-A0210	Cerulenin		≥99.0%	Unkown
HY-120394	TVB-3166		99.69%	Unkown
HY-120062	TVB-3664	Inhibitor	99.76%	Unkown
HY-12325	GSK2194069	Inhibitor	99.80%	Unkown
HY-16100	BI 99179	Inhibitor	99.38%	Unkown
HY-124628	IPI-9119	Inhibitor	98.91%	Unkown
HY-121250	Fasnall		99.94%	Unkown
HY-N3415	Kumatakenin		99.31%	Unkown
HY-12364A	trans-C75	Inhibitor	99.79%	Unkown
HY-B0218R	Orlistat (Standard)		98.21%	Unkown
HY-111551	FT113	Inhibitor	99.39%	Unkown
HY-116568	Prothioconazole		99.52%	Unkown
HY-N2486	Desoxyrhaponticin		99.80%	Unkown
HY-12648A	FASN-IN-4 tosylate	Inhibitor	98.55%	Unkown
HY-110354	UCM05	Inhibitor	99.22%	Unkown
HY-111777	FASN-IN-1	Inhibitor	99.69%	Unkown
HY-N1399	Androsin		99.94%	Unkown
HY-145809	FASN-IN-5	Inhibitor	99.98%	Unkown
HY-117769	GSK837149A	Inhibitor	99.13%	Unkown
HY-B0218S	Orlistat-d3		99.9%	Unkown
HY-N12124	Monascuspiloin		95%	Unkown
HY-12648	FASN-IN-4	Inhibitor	99.21%	Unkown
HY-N8144	Niga-ichigoside F1		99.0%	Unkown
HY-RS04753	FASN Human Pre-designed siRNA Set A		/	Unkown
HY-RS04754	Fasn Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS04755	Fasn Rat Pre-designed siRNA Set A		/	Unkown
HY-U00436	FASN-IN-3	Inhibitor	98.06%	Unkown
HY-W587772	Mono(2-ethyl-5-hydroxyhexyl) terephthalate		98.27%	Unkown
HY-110354R	UCM05 (Standard)	Inhibitor	/	Unkown
HY-112522	HS79	Inhibitor	/	Unkown
HY-112522A	HS80	Inhibitor	/	Unkown
HY-12364B	(−)-C75		/	Unkown
HY-149540	CTL-06	Inhibitor	/	Unkown
HY-149541	CTL-12	Inhibitor	/	Unkown
HY-155282	FASN-IN-6	Inhibitor	/	Unkown
HY-158649	Fasnall benzenesulfonate		/	Unkown
HY-15957	FASN-IN-7	Inhibitor	/	Unkown
HY-170570	PFM046		/	Unkown
HY-175020	QNX-10		/	Unkown
HY-176274	FASN/SCD-IN-1		/	Unkown
HY-181801	FASN-IN-8		/	Unkown
HY-182750	ACLY-IN-3	Inhibitor	/	Unkown
HY-182751	ACLY-IN-4	Inhibitor	/	Unkown
HY-N17737	Floramanoside F		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FASN	VGNC	VGNC:62152
Bos taurus	FASN	VGNC	VGNC:28871
Mus musculus	FASN	MGD	MGI:95485
Rattus norvegicus	FASN	RGD	RGD:620665
Canis familiaris	FASN	VGNC	VGNC:40736
Macaca mulatta	FASN	VGNC	VGNC:72616
Others	FASN	NCBI