Irak1 - interleukin-1 receptor-associated kinase 1 Gene

Also Known as IRAK; Plpk; mPLK; IRAK-1; IRAK1b; Il1rak; IRAK1-S

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16179

About Irak1

Chromosome X: 73,057,520-73,067,524 reverse strand.GRCm39:CM001013.3

This gene has 22 transcripts (splice variants), 187 orthologues, 4 paralogues and is associated with 6 phenotypes. Ubiquitous expression in adrenal adult (RPKM 73.), ovary adult (RPKM 47.6) and 27 other tissues.

Summary

Enables interleukin-1 receptor binding activity and protein kinase activity. Involved in negative regulation of Cholesterol efflux; negative regulation of transcription, DNA-templated; and positive regulation of JUN kinase activity. Acts upstream of or within several processes, including interleukin-1-mediated signaling pathway; response to molecule of Bacterial origin; and Toll-like Receptor signaling pathway. Located in lipid droplet and membrane. Part of protein-containing complex. Is expressed in several structures, including liver; skeletal muscle; and urinary system. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Irak1 Products (5)

mRNA Protein Name
NM_001177973.1 NP_001171444.1 interleukin-1 receptor-associated kinase 1 isoform 1
NM_001177974.1 NP_001171445.1 interleukin-1 receptor-associated kinase 1 isoform 4
NM_008363.2 NP_032389.2 interleukin-1 receptor-associated kinase 1 isoform 4
NM_001177975.1 NP_001171446.1 interleukin-1 receptor-associated kinase 1 isoform 3
NM_001177976.1 NP_001171447.1 interleukin-1 receptor-associated kinase 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables interleukin-1 receptor binding IPI
IPI: Inferred from physical interaction
15292196 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10854325 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
10549626 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
15292196 MGI
involved in innate immune response IEP
IEP: Inferred from expression pattern
16831874 MGI
acts upstream of or within interleukin-1-mediated signaling pathway IDA
IDA: Inferred from direct assay
12054681 MGI
involved in interleukin-1-mediated signaling pathway IDA
IDA: Inferred from direct assay
10854325 MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway IDA
IDA: Inferred from direct assay
10549626 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19752193 MGI
involved in negative regulation of cholesterol efflux IMP
IMP: Inferred from mutant phenotype
19752193 MGI
involved in positive regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
17379480 MGI
involved in positive regulation of MAP kinase activity IMP
IMP: Inferred from mutant phenotype
17379480 MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
12054681 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
10549626 MGI
acts upstream of or within response to lipopolysaccharide IDA
IDA: Inferred from direct assay
10549626 MGI
acts upstream of or within response to peptidoglycan IDA
IDA: Inferred from direct assay
10549626 MGI
acts upstream of or within toll-like receptor 2 signaling pathway IDA
IDA: Inferred from direct assay
10549626 MGI
acts upstream of or within toll-like receptor 4 signaling pathway IDA
IDA: Inferred from direct assay
10549626 MGI
Cellular Component GO Annotation Evidence References Source
located in lipid droplet IDA
IDA: Inferred from direct assay
21435586 MGI
located in membrane IDA
IDA: Inferred from direct assay
16831874 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
10854325 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Irak1 Protein Structure

Death_IRAK1

Death_IRAK1: cd08794 (16 - 99)

PKc_like

PKc_like: cl21453 (218 - 521)

  • 0
  • 200
  • 400
  • 600
  • 711 a.a.
Protein Preferred Names Protein Names

interleukin-1 receptor-associated kinase 1

  • interleukin-1 receptor-associated kinase-1b

  • pelle-like protein kinase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0380 Trimebutine Inhibitor 99.42% Yes
HY-B0380A Trimebutine maleate Inhibitor 99.66% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-160487 KME-2780 Inhibitor 98.94% Phase 2

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0039 Ginsenoside Rb1 Inhibitor 99.75% Unkown
HY-147141 HS-276 Inhibitor 98.93% Unkown
HY-103017A JH-X-119-01 Inhibitor 99.65% Unkown
HY-153188 JNJ-1013 Degrader 99.97% Unkown
HY-111101 AZ1495 Inhibitor 98.07% Unkown
HY-103017 JH-X-119-01 hydrochloride Inhibitor 99.14% Unkown
HY-137342 SB1-G-187 Degrader 98.70% Unkown
HY-134911 HS-243 Inhibitor 99.95% Unkown
HY-159953 IRAK1/4/pan-FLT3 Kinase-IN-1 Inhibitor 99.25% Unkown
HY-153110 Larotinib Inhibitor 99.50% Unkown
HY-153224 GLPG2534 Inhibitor 98.73% Unkown
HY-153110A Larotinib mesylate hydrate Inhibitor 98.66% Unkown
HY-N0039R Ginsenoside Rb1 (Standard) Inhibitor 99.26% Unkown
HY-177515 IRAK4 modulator-2 Inhibitor 99.86% Unkown
HY-179095 UR241-2 Inhibitor 99.68% Unkown
HY-159953A IRAK1/4/pan-FLT3 Kinase-IN-1 hydrochloride Inhibitor 98.46% Unkown
HY-147141A HS-276 hydrochloride Inhibitor / Unkown
HY-181712 IRAK1-IN-2 Inhibitor / Unkown
HY-162641 AF-45 Inhibitor / Unkown
HY-B0380S2 Trimebutine-d3 hydrochloride Inhibitor / Unkown
HY-125142 AP-24567 Inhibitor / Unkown
HY-147141B HS-276 formic Inhibitor / Unkown
HY-B0380S1 Trimebutine-d5 fumarate Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irak1 NCBI NCBI:3654