2. Gene
  3. Irak1 - interleukin-1 receptor-associated kinase 1 Gene

Irak1 - interleukin-1 receptor-associated kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as IRAK; Plpk; mPLK; IRAK-1; IRAK1b; Il1rak; IRAK1-S

Gene ID: 16179 | Gene type: protein coding

About Irak1

Chromosome X: 73,057,520-73,067,524 reverse strand.GRCm39:CM001013.3

This gene has 22 transcripts (splice variants), 187 orthologues, 4 paralogues and is associated with 6 phenotypes. Ubiquitous expression in adrenal adult (RPKM 73.), ovary adult (RPKM 47.6) and 27 other tissues.

Summary

Enables interleukin-1 receptor binding activity and protein kinase activity. Involved in negative regulation of Cholesterol efflux; negative regulation of transcription, DNA-templated; and positive regulation of JUN kinase activity. Acts upstream of or within several processes, including interleukin-1-mediated signaling pathway; response to molecule of Bacterial origin; and Toll-like Receptor signaling pathway. Located in lipid droplet and membrane. Part of protein-containing complex. Is expressed in several structures, including liver; skeletal muscle; and urinary system. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Irak1 Products(5)

mRNA Protein Name
NM_001177973.1 NP_001171444.1 interleukin-1 receptor-associated kinase 1 isoform 1
NM_001177974.1 NP_001171445.1 interleukin-1 receptor-associated kinase 1 isoform 4
NM_008363.2 NP_032389.2 interleukin-1 receptor-associated kinase 1 isoform 4
NM_001177975.1 NP_001171446.1 interleukin-1 receptor-associated kinase 1 isoform 3
NM_001177976.1 NP_001171447.1 interleukin-1 receptor-associated kinase 1 isoform 2

Irak1 Protein Structure

Death_IRAK1

Death_IRAK1: cd08794 (16 - 99)

PKc_like

PKc_like: cl21453 (218 - 521)

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  • 711 a.a.
Protein Preferred Names Protein Names

interleukin-1 receptor-associated kinase 1

interleukin-1 receptor-associated kinase-1b

pelle-like protein kinase

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0039 Ginsenoside Rb1 Inhibitor 98.75% Unkown
HY-103017 JH-X-119-01 hydrochloride Inhibitor 98.15% Unkown
HY-147141 HS-276 Inhibitor 98.59% Unkown
HY-103017A JH-X-119-01 Inhibitor ≥98.0% Unkown
HY-111101 AZ1495 Inhibitor 98.18% Unkown
HY-134911 HS-243 Inhibitor 99.88% Unkown
HY-153188 JNJ-1013 Degrader 99.80% Unkown
HY-153110A Larotinib mesylate hydrate Inhibitor 98.66% Unkown
HY-153224 GLPG2534 Inhibitor 98.05% Unkown
HY-153110 Larotinib Inhibitor / Unkown
HY-160487 KME-2780 Inhibitor / Unkown
HY-N0039R Ginsenoside Rb1 (Standard) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irak1 NCBI NCBI:3654