Pim2 - proviral integration site 2 Gene

Also Known as Pim-2; DXCch3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18715

About Pim2

Chromosome X: 7,744,501-7,749,671 forward strand.GRCm39:CM001013.3

This gene has 3 transcripts (splice variants), 115 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in spleen adult (RPKM 19.6), thymus adult (RPKM 12.7) and 28 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of autophagy; and protein stabilization. Acts upstream of or within several processes, including apoptotic mitochondrial changes; negative regulation of protein binding activity; and positive regulation of macroautophagy. Predicted to be active in cytoplasm. Is expressed in spleen and thymus. Orthologous to human PIM2 (Pim-2 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Pim2 Products (1)

mRNA Protein Name
NM_138606.2 NP_613072.1 serine/threonine-protein kinase pim-2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11854514 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
11854514 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12869584 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic mitochondrial changes IDA
IDA: Inferred from direct assay
12869584 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
17476689 MGI
acts upstream of macroautophagy IMP
IMP: Inferred from mutant phenotype
17476689 MGI
acts upstream of or within negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
12869584 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17476689 MGI
acts upstream of or within negative regulation of protein binding IMP
IMP: Inferred from mutant phenotype
17476689 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18438430 MGI
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
17476689 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
15548703 MGI
acts upstream of or within positive regulation of macroautophagy IMP
IMP: Inferred from mutant phenotype
17476689 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
15548703 MGI
involved in protein stabilization IDA
IDA: Inferred from direct assay
18438430 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pim2 Protein Structure

PKc_like

PKc_like: cl21453 (89 - 345)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase pim-2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-101870B Uzansertib phosphate Inhibitor 99.77% Phase 2
HY-101870 Uzansertib Inhibitor 99.45% Phase 2
HY-15604 AZD1208 Inhibitor 99.73% Phase 1
HY-15698 CRT0066101 Inhibitor 99.88% Phase 1
HY-19322 PIM447 Inhibitor 99.52% Phase 1
HY-19322B PIM-447 dihydrochloride Inhibitor 99.82% Phase 1
HY-15604A AZD1208 hydrochloride Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (22)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15698A CRT0066101 dihydrochloride Inhibitor 99.97% Unkown
HY-16576A SMI-4a Inhibitor 99.85% Unkown
HY-N4149 Quercetagetin Inhibitor 99.94% Unkown
HY-16976 GDC-0339 Inhibitor 99.87% Unkown
HY-101947 SMI-16a Inhibitor 98.0% Unkown
HY-120758 SEL24-B489 Inhibitor 99.02% Unkown
HY-122665 HTH-01-091 Inhibitor 99.81% Unkown
HY-115590 JP-11646 Inhibitor 98.74% Unkown
HY-111552 PIM1-IN-1 Inhibitor 99.83% Unkown
HY-164460 AZD1897 Inhibitor 99.69% Unkown
HY-123983 HS56 Inhibitor 99.6% Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-15698B CRT0066101 trihydrochloride Inhibitor / Unkown
HY-101783 GNE-955 Inhibitor / Unkown
HY-181925 FD2024 Inhibitor / Unkown
HY-163442A PIM3-IN-1 hydrochloride Inhibitor / Unkown
HY-160006 PIM-IN-2 / Unkown
HY-186146 SGI-1776-VHL-02 Degrader 96.67% Unkown
HY-122670 VS-II-173 Inhibitor / Unkown
HY-168479 VB1080 Inhibitor / Unkown
HY-163119 Pim-1 kinase inhibitor 9 Inhibitor / Unkown
HY-157404 Pim-1/2 kinase inhibitor 2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pim2 NCBI NCBI:11040