Scd1 - stearoyl-Coenzyme A desaturase 1 Gene

Also Known as ab; Scd; Scd-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20249

About Scd1

Chromosome 19: 44,382,894-44,396,318 reverse strand.GRCm39:CM001012.3

This gene has 3 transcripts (splice variants), 29 orthologues, 3 paralogues and is associated with 79 phenotypes. Biased expression in subcutaneous fat pad adult (RPKM 3754.4), mammary gland adult (RPKM 322.4) and 5 other tissues.

Summary

Enables metal ion binding activity; palmitoyl-CoA 9-desaturase activity; and stearoyl-CoA 9-desaturase activity. Involved in several processes, including Cholesterol esterification; positive regulation of cold-induced thermogenesis; and tarsal gland development. Acts upstream of or within several processes, including brown fat cell differentiation; monounsaturated fatty acid biosynthetic process; and white fat cell differentiation. Is integral component of endoplasmic reticulum membrane. Is expressed in several structures, including adipose tissue; central nervous system; cranium; integumental system; and liver. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to several human genes including SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Apr 2022]

Scd1 Products (1)

mRNA Protein Name
NM_009127.4 NP_033153.2 acyl-CoA desaturase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables metal ion binding IDA
IDA: Inferred from direct assay
26098370 MGI
enables palmitoyl-CoA 9-desaturase activity IDA
IDA: Inferred from direct assay
16443825 MGI
enables palmitoyl-CoA 9-desaturase activity IGI
IGI: Inferred from genetic interaction
16443825 MGI
enables stearoyl-CoA 9-desaturase activity IDA
IDA: Inferred from direct assay
16443825 MGI
enables stearoyl-CoA 9-desaturase activity IGI
IGI: Inferred from genetic interaction
16443825 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within brown fat cell differentiation IDA
IDA: Inferred from direct assay
18492766 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
16040962 MGI
acts upstream of or within fatty acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
12815040 MGI
acts upstream of or within lipid homeostasis IMP
IMP: Inferred from mutant phenotype
16040962 MGI
acts upstream of or within monounsaturated fatty acid biosynthetic process IDA
IDA: Inferred from direct assay
16443825 MGI
acts upstream of or within monounsaturated fatty acid biosynthetic process IGI
IGI: Inferred from genetic interaction
16443825 MGI
involved in monounsaturated fatty acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
10899171 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
15210843 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
involved in sebaceous gland development IMP
IMP: Inferred from mutant phenotype
10854228 MGI
involved in sterol homeostasis IMP
IMP: Inferred from mutant phenotype
10854228 MGI
involved in tarsal gland development IMP
IMP: Inferred from mutant phenotype
10854228 MGI
involved in triglyceride metabolic process IMP
IMP: Inferred from mutant phenotype
10899171 MGI
acts upstream of or within white fat cell differentiation IDA
IDA: Inferred from direct assay
18492766 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
16275639 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scd1 Protein Structure

Delta9-FADS-like

Delta9-FADS-like: cd03505 (92 - 332)

  • 0
  • 100
  • 200
  • 300
  • 355 a.a.
Protein Preferred Names Protein Names

acyl-CoA desaturase 1

  • asebia

  • delta(9)-desaturase 1

  • fatty acid desaturase 1

  • stearoyl-CoA desaturase 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-19796 Icomidocholic acid 99.98% Phase 3
HY-148788 Osivelotor Inhibitor 98.10% Phase 3
HY-13070 MK-8245 Inhibitor 99.04% Phase 2
HY-13077 MK-8245 Trifluoroacetate Inhibitor 98.45% Phase 2

Pre-clinical Phase

Bioactive Molecules (34)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50709 A939572 Inhibitor 99.98% Unkown
HY-15823 CAY10566 Inhibitor 99.93% Unkown
HY-155033 SSI-4 99.99% Unkown
HY-12756 E6446 98.78% Unkown
HY-12756A E6446 dihydrochloride 99.29% Unkown
HY-15822 MF-438 Inhibitor 99.92% Unkown
HY-127143 Sterculic acid Inhibitor ≥99.0% Unkown
HY-169761B (R,R)-dWIZ-1 TFA Control 98.58% Unkown
HY-141525 SCD1 inhibitor-4 Inhibitor 98.73% Unkown
HY-112812 SCD1 inhibitor-1 Inhibitor 99.91% Unkown
HY-N6807 Elemicin Inhibitor 98.02% Unkown
HY-124751 YTX-465 Inhibitor 99.06% Unkown
HY-139077 SCD1 inhibitor-3 Inhibitor 98.24% Unkown
HY-E70265 18:0 Coenzyme A triammonium 99.9% Unkown
HY-N3388 Licoisoflavone B Inhibitor 99.46% Unkown
HY-155403 SCD1/5-IN-1 Inhibitor 99.07% Unkown
HY-100249 XEN723 Inhibitor 99.30% Unkown
HY-N8144 Niga-ichigoside F1 99.0% Unkown
HY-RS12496 Scd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N7521 Procyanidin C2 / Unkown
HY-RS12494 SCD Human Pre-designed siRNA Set A / Unkown
HY-111315 XEN103 Inhibitor / Unkown
HY-118117 Rovatirelin / Unkown
HY-150125 SCD1-IN-1 Inhibitor / Unkown
HY-152775A RK-0133114 Inhibitor / Unkown
HY-161787 G9a-IN-2 Inhibitor / Unkown
HY-170570 PFM046 / Unkown
HY-182046 HD202A / Unkown
HY-34603 1-Methyl-1H-pyrazole-3-carboxylic acid 99.53% Unkown
HY-RS12495 Scd Rat Pre-designed siRNA Set A / Unkown
HY-W175543 Methoxyurea Substrate / Unkown
HY-155209 SCD1 inhibitor-5 Inhibitor / Unkown
HY-N10612 Petasin / Unkown
HY-W013627S trans,trans-2,4-Decadienal-d4 / Unkown