Stat1 - signal transducer and activator of transcription 1 Gene

Also Known as 2010005J02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20846

Summary

Enables DNA-binding transcription factor activity. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and defense response to Other organism. Acts upstream of or within several processes, including cell surface receptor signaling pathway; negative regulation of macrophage fusion; and response to exogenous dsRNA. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and skeletal musculature. Used to study breast Cancer and severe acute respiratory syndrome. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 31A; immunodeficiency 31B; immunodeficiency 31C; and prostate adenocarcinoma. Orthologous to human STAT1 (signal transducer and activator of transcription 1). [provided by Alliance of Genome Resources, Apr 2022]

Stat1 Products (4)

mRNA Protein Name
NM_001205313.1 NP_001192242.1 signal transducer and activator of transcription 1 isoform 1
NM_001205314.1 NP_001192243.1 signal transducer and activator of transcription 1 isoform 2
NM_001357627.1 NP_001344556.1 signal transducer and activator of transcription 1 isoform 2
NM_009283.4 NP_033309.3 signal transducer and activator of transcription 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
37327784 MGI
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
15485925 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11972023 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22306691 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
15485925 MGI
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
10692450 MGI
involved in cell population proliferation IGI
IGI: Inferred from genetic interaction
15781341 MGI
involved in cell surface receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
11972023 MGI
acts upstream of or within cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
21606371 MGI
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
12872135 MGI
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
32270034 MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway IDA
IDA: Inferred from direct assay
12872135 MGI
acts upstream of or within negative regulation of macrophage fusion IMP
IMP: Inferred from mutant phenotype
22865856 MGI
acts upstream of or within response to bacterium IDA
IDA: Inferred from direct assay
15661922 MGI
acts upstream of or within response to exogenous dsRNA IDA
IDA: Inferred from direct assay
12872135 MGI
acts upstream of or within response to lipopolysaccharide IDA
IDA: Inferred from direct assay
12872135 MGI
involved in response to type I interferon IDA
IDA: Inferred from direct assay
24882218 MGI
involved in response to type II interferon IDA
IDA: Inferred from direct assay
11972023 MGI
involved in type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
12138178 MGI
involved in type II interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
12138178 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12634107 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12957148 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

signal transducer and activator of transcription 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-117287 Deucravacitinib Inhibitor 99.93% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-112288 C188-9 Inhibitor 99.84% Phase 2
HY-106981 Orazipone Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (33)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W008510 2-Chloro-5-(trifluoromethyl)pyrimidine Inducer 99.96% Unkown
HY-115594 Erasin Inhibitor 96.02% Unkown
HY-173236 STAT4-IN-1 Inhibitor 99.17% Unkown
HY-119024 BCI-137 Activator 99.84% Unkown
HY-170621 STAT1/3-IN-1 Inhibitor 99.23% Unkown
HY-116940 Sm4 Inhibitor 99.01% Unkown
HY-122891 SB02024 Activator 99.70% Unkown
HY-W031757 Anthraquinone-2-carboxylic acid Inhibitor 98.0% Unkown
HY-149209 LL-K8-22 Inhibitor 99.06% Unkown
HY-169360 SD-436 Degrader 98.27% Unkown
HY-158142 PROTAC TYK2 degrader-1 Inhibitor 99.55% Unkown
HY-N12586 Pheophytin a Inhibitor 80.0% Unkown
HY-17663 KMR-206 Activator 98.86% Unkown
HY-156466 QL-1200186 Inhibitor 99.95% Unkown
HY-161060 Zharp1-211 Inhibitor 99.15% Unkown
HY-181792 ZDZ-553 Inhibitor 99.91% Unkown
HY-173679 RBN012811 Activator 98.79% Unkown
HY-181653 PROTAC SKP2 Degrader-1 Modulator 99.91% Unkown
HY-P1758 IFN-α Receptor Recognition Peptide 1 Inhibitor / Unkown
HY-119956 Biflorin Inhibitor 99.54% Unkown
HY-P1758A IFN-α Receptor Recognition Peptide 1 acetate Inhibitor 99.29% Unkown
HY-114178 CDK8-IN-2 Inhibitor / Unkown
HY-178916 ITA-9 Inhibitor / Unkown
HY-178716 PTPN2/1-IN-4 Modulator / Unkown
HY-180226 Apoptosis inducer 55 Inhibitor / Unkown
HY-183748 XL-20 Activator / Unkown
HY-183554 Fa-Au Activator / Unkown
HY-184118 ADGRL1-IN-1 Activator / Unkown
HY-184119 Pabgraminone C Modulator / Unkown
HY-183937A PD-305 Activator / Unkown
HY-178915 ITA-5 Inhibitor / Unkown
HY-183537 KSI-028 Inhibitor / Unkown
HY-179288 TPST2-IN-1 / Unkown
Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99143 Anti-Mouse NK1.1 Antibody (PK136) Inhibitor 98.57% Unkown
HY-P992321 BAY-356 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stat1 NCBI NCBI:6772