2. Gene
  3. Met - MET proto-oncogene, receptor tyrosine kinase Gene

Met - MET proto-oncogene, receptor tyrosine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Hgfr

Gene ID: 24553 | Gene type: protein coding

About Met

Primary_assembly 4: 45,790,791-45,897,876 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 207 orthologues, 54 paralogues and is associated with 88 phenotypes. Biased expression in Kidney (RPKM 289.7), Liver (RPKM 253.1) and 8 other tissues.

Summary

Enables several functions, including beta-catenin binding activity; hepatocyte growth factor-activated receptor activity; and Phospholipase binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of macromolecule metabolic process. Located in several cellular components, including postsynaptic density; postsynaptic membrane; and sperm flagellum. Biomarker of several diseases, including acute kidney failure; hepatobiliary system Cancer (multiple); liver benign neoplasm; pancreatitis; and periodontitis. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Met Products(1)

mRNA Protein Name
NM_031517.2 NP_113705.1 hepatocyte growth factor receptor precursor

Met Protein Structure

Sema

Sema: cl15693 (24 - 516)

PSI

PSI: smart00423 (519 - 561)

IPT_plexin_repeat1

IPT_plexin_repeat1: cd01180 (563 - 656)

IPT_plexin_repeat2

IPT_plexin_repeat2: cd01179 (657 - 738)

IPT

IPT: cl15674 (742 - 837)

IPT

IPT: smart00429 (838 - 902)

PTKc_Met_Ron

PTKc_Met_Ron: cd05058 (1082 - 1343)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1382 a.a.
Protein Preferred Names Protein Names

hepatocyte growth factor receptor

HGF receptor

HGF/SF receptor

SF receptor

c-Met

met proto-oncogene tyrosine kinase

proto-oncogene c-Met

scatter factor receptor

tyrosine-protein kinase Met

Recombinant Met Proteins

Cat. No. Product Name Accession Purity
HY-P72942 HGFR Protein, Rat (HEK293, Fc) Q2IBC7 (E25-N932) ≥95%

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13016 Cabozantinib Inhibitor 99.96% Yes
Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-12035 AMG-208 Inhibitor 99.86% Phase 2
HY-16446 SAR125844 Inhibitor 98.11% Phase 2
HY-50683 JNJ-38877605 Inhibitor 99.95% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99455 Bafisontamab Inhibitor 96.00% Phase 3
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114357A DS-1205b free base Inhibitor 99.92% Unkown
HY-161372 PARP1/c-Met-IN-1 Inhibitor / Unkown
HY-157387 c-Met-IN-22 Inhibitor / Unkown
HY-120908 c-Met-IN-16 Inhibitor / Unkown
HY-149675 VEGFR-2/c-Met-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Met NCBI NCBI:4233
Canis familiaris Met NCBI NCBI:403438
Macaca fascicularis Met NCBI NCBI:102123512
Mus musculus Met NCBI NCBI:17295
Susscrofa domestica Met NCBI
Macaca mulatta Met NCBI NCBI:704562