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Met - MET proto-oncogene, receptor tyrosine kinase Gene

Also Known as Hgfr

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24553

About Met

Primary_assembly 4: 45,790,791-45,897,876 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 207 orthologues, 54 paralogues and is associated with 88 phenotypes. Biased expression in Kidney (RPKM 289.7), Liver (RPKM 253.1) and 8 other tissues.

Summary

Enables several functions, including beta-catenin binding activity; hepatocyte growth factor-activated receptor activity; and Phospholipase binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of macromolecule metabolic process. Located in several cellular components, including postsynaptic density; postsynaptic membrane; and sperm flagellum. Biomarker of several diseases, including acute kidney failure; hepatobiliary system Cancer (multiple); liver benign neoplasm; pancreatitis; and periodontitis. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Met Products (1)

mRNA	Protein	Name
NM_031517.2	NP_113705.1	hepatocyte growth factor receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	16952352	RGD
enables hepatocyte growth factor receptor activity	IMP IMP: Inferred from mutant phenotype	18262389	RGD
enables phosphatidylinositol 3-kinase binding	IDA IDA: Inferred from direct assay	7499789	RGD
enables phospholipase binding	IPI IPI: Inferred from physical interaction	7499789	RGD
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7499789	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	8833090	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to arsenic-containing substance	IEP IEP: Inferred from expression pattern	16876216	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	17124385	RGD
involved in cellular response to growth factor stimulus	IEP IEP: Inferred from expression pattern	7526865	RGD
involved in cellular response to interleukin-6	IEP IEP: Inferred from expression pattern	8853431	RGD
involved in cellular response to peptide hormone stimulus	IEP IEP: Inferred from expression pattern	17035232	RGD
involved in central nervous system neuron differentiation	IEP IEP: Inferred from expression pattern	18262389	RGD
involved in flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	12399538	RGD
involved in lactation	IEP IEP: Inferred from expression pattern	7628535	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	8506951	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	11316747	RGD
involved in negative regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	18262389	RGD
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17427161	RGD
involved in neuron migration	IDA IDA: Inferred from direct assay	12106690	RGD
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	12106690	RGD
involved in oligodendrocyte development	IEP IEP: Inferred from expression pattern	17382307	RGD
involved in pancreas development	IEP IEP: Inferred from expression pattern	8954115	RGD
involved in positive regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	17427161	RGD
involved in positive regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	18262389	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18262389	RGD
involved in positive regulation of mitotic nuclear division	IMP IMP: Inferred from mutant phenotype	17427161	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	18262389	RGD
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	18262389	RGD
involved in positive regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	18262389	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17427161	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	7499789	RGD
involved in response to acidic pH	IEP IEP: Inferred from expression pattern	7729276	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19638569	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	17412609	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18652820	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in dendrite	IDA IDA: Inferred from direct assay	17230549	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	16861928	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	19794968	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	16861928	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	16861928	RGD
located in sperm flagellum	IDA IDA: Inferred from direct assay	12399538	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Met Protein Structure

Sema

PSI

IPT_plexin_repeat1

IPT_plexin_repeat2

IPT

PTKc_Met_Ron

0
300
600
900
1200
1382 a.a.

Protein Preferred Names	Protein Names
hepatocyte growth factor receptor	HGF receptor HGF/SF receptor SF receptor c-Met met proto-oncogene tyrosine kinase proto-oncogene c-Met scatter factor receptor tyrosine-protein kinase Met

Recombinant Met Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72942	HGFR Protein, Rat (HEK293, Fc)	Q2IBC7 (E25-N932)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13016	Cabozantinib	Inhibitor	99.97%	Yes
HY-13404	Capmatinib	Inhibitor	99.71%	Yes
HY-14721	Tepotinib	Inhibitor	99.94%	Yes

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16446	SAR125844	Inhibitor	98.17%	Phase 2
HY-12035	AMG-208	Inhibitor	99.86%	Phase 2
HY-50683	JNJ-38877605	Inhibitor	99.95%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99455	Bafisontamab	Inhibitor	99.9%	Phase 3

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12017	PF-04217903	Inhibitor	99.85%	Unkown
HY-123961	SJF-8240	Degrader	99.33%	Unkown
HY-168135	PROTAC c-Met degrader-1	Degrader	98.48%	Unkown
HY-12017A	PF-04217903 mesylate	Inhibitor	99.82%	Unkown
HY-114357A	DS-1205b free base	Inhibitor	99.92%	Unkown
HY-157551	JNK-IN-16	Inhibitor	99.82%	Unkown
HY-12017B	PF-04217903 phenolsulfonate	Inhibitor	/	Unkown
HY-13752	STA-1474	Inhibitor	/	Unkown
HY-183579	c-Met-IN-27	Inhibitor	/	Unkown
HY-162803	c-Met-IN-24	Inhibitor	/	Unkown
HY-D3352	EMI-137		/	Unkown
HY-179098	Multi-target kinase-IN-8	Inhibitor	/	Unkown
HY-175321	PROTAC c-Met degrader-6	Degrader	/	Unkown
HY-161372	PARP1/c-Met-IN-1	Inhibitor	/	Unkown
HY-184305	c-Met-IN-30	Inhibitor	/	Unkown
HY-157387	c-Met-IN-22	Inhibitor	/	Unkown
HY-168910	PROTAC c-Met degrader-3	Degrader	/	Unkown
HY-171824	PROTAC c-Met Degrader-4	Degrader	/	Unkown
HY-181928	PARP1/c-Met-IN-3	Inhibitor	/	Unkown
HY-178348	PARP1/c-Met-IN-2	Inhibitor	/	Unkown
HY-123237	KRC-108	Inhibitor	/	Unkown
HY-120908	c-Met-IN-16	Inhibitor	/	Unkown
HY-175848	NSC 850745	Inhibitor	/	Unkown
HY-45124	3-Fluoro-desmethyl-cabozantinib		/	Unkown
HY-149675	VEGFR-2/c-Met-IN-2	Inhibitor	/	Unkown
HY-181776	c-Met-IN-31	Inhibitor	/	Unkown
HY-179034	CAIX/XII-IN-16	Inhibitor	/	Unkown
HY-177134	Taligantinib	Inhibitor	/	Unkown
HY-W425461	c-Met ligand-1	Ligand	/	Unkown
HY-12017C	PF-04217903 phosphate	Inhibitor	/	Unkown
HY-13752B	STA-1474 sodium	Inhibitor	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992481	VERT-002	Degrader	/	Unkown
HY-P991565	CE-355621	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Met	NCBI	NCBI:4233