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Cav1 - caveolin 1 Gene

Also Known as Cav

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25404

Summary

Enables several functions, including enzyme binding activity; syntaxin binding activity; and transmembrane transporter binding activity. Involved in several processes, including positive regulation of cellular component organization; regulation of endothelial cell proliferation; and regulation of signal transduction. Located in several cellular components, including basal plasma membrane; focal adhesion; and lipid droplet. Part of protein-containing complex. Biomarker of several diseases, including artery disease (multiple); bone disease (multiple); brain ischemia (multiple); obesity; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including breast Cancer (multiple); lipodystrophy (multiple); primary open angle glaucoma; primary pulmonary hypertension; and systemic scleroderma (multiple). Orthologous to human CAV1 (caveolin 1). [provided by Alliance of Genome Resources, Apr 2022]

Cav1 Products (2)

mRNA	Protein	Name
NM_031556.3	NP_113744.2	caveolin-1 isoform alpha
NM_133651.2	NP_598412.2	caveolin-1 isoform beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SNARE binding	IMP IMP: Inferred from mutant phenotype	11883949	RGD
enables kinase binding	IPI IPI: Inferred from physical interaction	16419038	RGD
enables nitric-oxide synthase binding	IPI IPI: Inferred from physical interaction	17277024	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12646183	RGD
enables receptor serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	28162981	RGD
enables syntaxin binding	IMP IMP: Inferred from mutant phenotype	11883949	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	18923542	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	22431231	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	29069575	RGD
involved in cellular response to mechanical stimulus	IDA IDA: Inferred from direct assay	20172952	RGD
involved in cellular senescence	IMP IMP: Inferred from mutant phenotype	23941874	RGD
involved in cholesterol efflux	IMP IMP: Inferred from mutant phenotype	17499231	RGD
involved in intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	17337601	RGD
involved in maintenance of protein location in cell	IMP IMP: Inferred from mutant phenotype	18162583	RGD
involved in microtubule polymerization	IMP IMP: Inferred from mutant phenotype	16480946	RGD
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	20172952	RGD
involved in negative regulation of calcium ion import across plasma membrane	IMP IMP: Inferred from mutant phenotype	29069575	RGD
involved in negative regulation of cation channel activity	IDA IDA: Inferred from direct assay	20624795	RGD
involved in negative regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16051704	RGD
involved in negative regulation of muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	18039791	RGD
involved in negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	21826216	RGD
involved in negative regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	29069575	RGD
involved in negative regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	20828553	RGD
involved in negative regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	29069575	RGD
involved in positive regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	17715130	RGD
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	20828553	RGD
involved in positive regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	16480946	RGD
involved in positive regulation of signal transduction	IMP IMP: Inferred from mutant phenotype	18039791	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	21098487	RGD
involved in response to gamma radiation	IEP IEP: Inferred from expression pattern	17993744	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	17537407	RGD
involved in response to mechanical stimulus	IMP IMP: Inferred from mutant phenotype	17446044	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	16335790	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17331262	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	18162583	RGD
located in basal plasma membrane	IDA IDA: Inferred from direct assay	16904002	RGD
located in caveola	IDA IDA: Inferred from direct assay	16419038	RGD
located in cell surface	IDA IDA: Inferred from direct assay	10887965	RGD
located in focal adhesion	IDA IDA: Inferred from direct assay	15731459	RGD
located in lipid droplet	IDA IDA: Inferred from direct assay	14528016	RGD
located in membrane raft	IDA IDA: Inferred from direct assay	18162583	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	19931615	RGD
located in peroxisomal membrane	IDA IDA: Inferred from direct assay	20146263	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	16306401	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	22492718	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
caveolin-1	caveolin 1, caveolae protein caveolin caveolae protein 22 kDa caveolin-like

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1090	Cinnarizine	Inhibitor	99.56%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112499	Menaquinone-7	Activator	98.51%	Phase 2
HY-112499R	Menaquinone-7 (Standard)		98.27%	Phase 2

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134542	CaV1.3 antagonist-1	Antagonist	98.38%	Unkown
HY-N2488	Demethylsuberosin	Inhibitor	99.71%	Unkown
HY-RS01986	CAV1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-B1752	Quinpirole		98.95%	Unkown
HY-106454	N-Desalkylflurazepam	Inhibitor	99.95%	Unkown
HY-RS17533	Cav1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-118202	(-)-Gallopamil	Inhibitor	/	Unkown
HY-118202A	(-)-Gallopamil hydrochloride	Inhibitor	/	Unkown
HY-126336	HM12	Inhibitor	/	Unkown
HY-146173	KCa1.1 channel activator-1		/	Unkown
HY-159090	AT1R antagonist 3		/	Unkown
HY-17402S	Nisoldipine-d6	Inhibitor	/	Unkown
HY-17402S3	Nisoldipine-d3	Inhibitor	/	Unkown
HY-175395	Onychocin B	Inhibitor	/	Unkown
HY-180547	MRC71		/	Unkown
HY-181755	Phenylaminojuglone AJ-2	Inhibitor	/	Unkown
HY-184190	ERG-IN-7	Inhibitor	/	Unkown
HY-N12859	Herbacetin 3-O-glucopyranoside-8-O-glucuronopyranoside		/	Unkown
HY-P3269A	Calciseptine TFA	Inhibitor	97.55%	Unkown
HY-W701464	N-Desalkylflurazepam-d4		/	Unkown
HY-Z15823	(R)-Verapamil		98.97%	Unkown
HY-Z7760	Felodipine 3,5-dimethyl ester	Modulator	/	Unkown
HY-116307	2-Thio-UTP	Agonist	/	Unkown
HY-122552	Chrysotobibenzyl	Inhibitor	/	Unkown
HY-156889	Cav 3.1 blocker 1	Antagonist	/	Unkown
HY-17402S1	Nisoldipine-d4	Inhibitor	/	Unkown
HY-17402S2	Nisoldipine-d7	Inhibitor	/	Unkown
HY-175226	DPP8/9-IN-2	Inhibitor	/	Unkown
HY-N4189	Isocucurbitacin B		98.98%	Unkown
HY-P3269	Calciseptine	Inhibitor	/	Unkown
HY-RS23990	Cav1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cav1	NCBI	NCBI:857