Slc7a11 - solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 Gene

Also Known as sut; xCT; 9930009M05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26570

Summary

Predicted to enable L-amino acid transmembrane transporter activity. Acts upstream of or within several processes, including animal organ development; oligopeptide transmembrane transport; and regulation of cellular amino acid metabolic process. Located in apical part of cell; astrocyte projection; and brush border membrane. Is expressed in brain; meninges; and sensory organ. Used to study Hermansky-Pudlak syndrome and platelet storage pool deficiency. Orthologous to human SLC7A11 (solute carrier family 7 member 11). [provided by Alliance of Genome Resources, Apr 2022]

Slc7a11 Products (1)

mRNA Protein Name
NM_011990.2 NP_036120.1 cystine/glutamate transporter

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in L-cystine transport IMP
IMP: Inferred from mutant phenotype
16037214 MGI
acts upstream of or within L-glutamate import across plasma membrane IMP
IMP: Inferred from mutant phenotype
21490221 MGI
acts upstream of or within adult behavior IDA
IDA: Inferred from direct assay
29024663 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
17035536 MGI
acts upstream of or within cellular response to oxidative stress IDA
IDA: Inferred from direct assay
17035536 MGI
acts upstream of or within cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
17035536 MGI
acts upstream of or within cellular response to stress IDA
IDA: Inferred from direct assay
29024663 MGI
acts upstream of or within dipeptide import across plasma membrane IMP
IMP: Inferred from mutant phenotype
16037214 MGI
acts upstream of or within glutathione metabolic process IMP
IMP: Inferred from mutant phenotype
17200146 MGI
acts upstream of or within glutathione transmembrane transport IDA
IDA: Inferred from direct assay
17035536 MGI
acts upstream of or within intracellular glutamate homeostasis IGI
IGI: Inferred from genetic interaction
29024663 MGI
acts upstream of or within intracellular glutamate homeostasis IMP
IMP: Inferred from mutant phenotype
21191088 MGI
acts upstream of or within limb development IMP
IMP: Inferred from mutant phenotype
21490221 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
23085521 MGI
acts upstream of or within modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
25429150 MGI
acts upstream of or within platelet aggregation IMP
IMP: Inferred from mutant phenotype
8699821 MGI
acts upstream of or within regulation of AMPA glutamate receptor clustering IMP
IMP: Inferred from mutant phenotype
25429150 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16037214 MGI
acts upstream of or within regulation of cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
16037214 MGI
acts upstream of or within regulation of cysteine metabolic process IMP
IMP: Inferred from mutant phenotype
17200146 MGI
acts upstream of or within regulation of glutamate metabolic process IMP
IMP: Inferred from mutant phenotype
21490221 MGI
acts upstream of or within regulation of glutathione biosynthetic process IMP
IMP: Inferred from mutant phenotype
16037214 MGI
acts upstream of or within regulation of melanin biosynthetic process IMP
IMP: Inferred from mutant phenotype
16037214 MGI
acts upstream of or within regulation of neutrophil apoptotic process IMP
IMP: Inferred from mutant phenotype
17200146 MGI
acts upstream of or within regulation of protein transport IMP
IMP: Inferred from mutant phenotype
16037214 MGI
acts upstream of or within regulation of synapse organization IMP
IMP: Inferred from mutant phenotype
25429150 MGI
acts upstream of or within response to organic cyclic compound IMP
IMP: Inferred from mutant phenotype
21191088 MGI
acts upstream of or within response to redox state IMP
IMP: Inferred from mutant phenotype
16144837 MGI
acts upstream of or within striatum development IMP
IMP: Inferred from mutant phenotype
17035536 MGI
acts upstream of or within ventricular system development IMP
IMP: Inferred from mutant phenotype
17035536 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
21490221 MGI
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
16399997 MGI
located in astrocyte projection IDA
IDA: Inferred from direct assay
16399997 MGI
located in brush border membrane IDA
IDA: Inferred from direct assay
16399997 MGI
located in membrane IDA
IDA: Inferred from direct assay
29350434 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16399997 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cystine/glutamate transporter

  • amino acid transport system xc-

  • cysteine/glutamate transporter

  • sodium independent anionic amino acid transport system

  • solute carrier family 7 member 11

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0653A Levobupivacaine hydrochloride 99.86% Yes
HY-B0653 Levobupivacaine 99.66% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-W402682 SXC2023 Activator 99.85% Phase 2

Pre-clinical Phase

Bioactive Molecules (33)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15763 Erastin 99.91% Unkown
HY-W451275 HG106 Activator 99.90% Unkown
HY-108894 Ferumoxytol Inducer 95.00% Unkown
HY-W018161 Hexadecanedioic acid Inhibitor 98.0% Unkown
HY-175032 ATF3-IN-1 96.30% Unkown
HY-145733 DI-1859 99.62% Unkown
HY-169056 SLC7A11-IN-2 99.80% Unkown
HY-149979 SLC7A11-IN-1 Inducer 97.06% Unkown
HY-RS13325 SLC7A11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N10549 Gigantol 99.79% Unkown
HY-179041 SZ0232 99.25% Unkown
HY-179528 DIM-3,5-Cl2 99.18% Unkown
HY-183622 UCI-1014 Activator 98.43% Unkown
HY-112005G DOPE (GMP) Inhibitor / Unkown
HY-155851 Lepadin E / Unkown
HY-155852 Lepadin H / Unkown
HY-161075 Microtubule inhibitor 8 / Unkown
HY-176719 AKR1B1/STAT3/SLC7A11-regulator-1 / Unkown
HY-180199 GPX4-IN-21 / Unkown
HY-181982 HJ03 / Unkown
HY-182052 Ferroptosis inducer-16 / Unkown
HY-183554 Fa-Au / Unkown
HY-184115 JHB-17 / Unkown
HY-184266 GCLCi0 Inducer / Unkown
HY-184267 GCLCi1 / Unkown
HY-184761 Keap1-Nrf2-IN-30 / Unkown
HY-B0653AS Levobupivacaine-d9 hydrochloride / Unkown
HY-D3311 M1219 / Unkown
HY-N17850 5-Hydroxy-6,7-dimethoxyflavone / Unkown
HY-P5762A Phoenixin-14 TFA / Unkown
HY-W018161S Hexadecanedioic acid-d28 99.21% Unkown
HY-RS16551 Slc7a11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22984 Slc7a11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc7a11 NCBI NCBI:23657