Atm - ATM serine/threonine kinase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 300711

About Atm

Primary_assembly 8: 53,831,093-53,932,437 reverse strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 226 orthologues, 5 paralogues and is associated with 113 phenotypes. Biased expression in Spleen (RPKM 259.9), Thymus (RPKM 189.4) and 9 other tissues.

Summary

Predicted to enable identical protein binding activity; phosphotransferase activity, alcohol group as acceptor; and protein N-terminus binding activity. Involved in several processes, including positive regulation of neuron apoptotic process; positive regulation of nitrogen compound metabolic process; and regulation of microglial cell activation. Located in cytoplasm and nucleus. Used to study ataxia telangiectasia; disease of cellular proliferation; infertility; leukemia; and lymphoma. Biomarker of pre-malignant neoplasm and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; endometrial cancer; lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Atm Products (1)

mRNA Protein Name
NM_001106821.1 NP_001100291.1 serine-protein kinase ATM

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
12915485 RGD
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
19151707 RGD
involved in cellular response to ionizing radiation IMP
IMP: Inferred from mutant phenotype
28007901 RGD
involved in positive regulation of DNA catabolic process IMP
IMP: Inferred from mutant phenotype
27895165 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
20502937 RGD
involved in regulation of microglial cell activation IMP
IMP: Inferred from mutant phenotype
28007901 RGD
involved in response to hypoxia IDA
IDA: Inferred from direct assay
16651613 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Atm Protein Structure

TAN

TAN: pfam11640 (7 - 164)

FAT

FAT: pfam02259 (2136 - 2528)

PIKKc_ATM

PIKKc_ATM: cd05171 (2722 - 3001)

FATC

FATC: pfam02260 (3065 - 3094)

  • 0
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  • 2000
  • 2500
  • 3096 a.a.
Protein Preferred Names Protein Names

serine-protein kinase ATM

  • Ataxia telangiectasia gene mutated in human beings

  • ataxia telangiectasia mutated homolog

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-109566 AZD1390 Inhibitor 99.22% Phase 3
HY-13902 Berzosertib Inhibitor 99.67% Phase 2
HY-139609 Camonsertib Inhibitor 99.99% Phase 2
HY-150617 Lartesertib Inhibitor 99.94% Phase 2
HY-111783G AZD-7648 (GMP) Inhibitor / Phase 2
HY-100016 AZD0156 Inhibitor 99.83% Phase 1

Pre-clinical Phase

Bioactive Molecules (26)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111783 AZD-7648 Inhibitor 99.86% Unkown
HY-12016 KU-55933 Inhibitor 99.92% Unkown
HY-14731 VE-821 Inhibitor 99.67% Unkown
HY-12061 KU-60019 Inhibitor 99.43% Unkown
HY-15520 CGK733 Inhibitor 99.71% Unkown
HY-15521 ETP-46464 Inhibitor 99.54% Unkown
HY-103241 Ro 90-7501 Inhibitor 98.50% Unkown
HY-11002 CP-466722 Inhibitor 99.74% Unkown
HY-112198 AZ31 Inhibitor 98.22% Unkown
HY-112305 AZ32 Inhibitor 99.81% Unkown
HY-158345 PROTAC ATM degrader-1 Degrader 98.01% Unkown
HY-112614 ATM Inhibitor-1 Inhibitor / Unkown
HY-174828 ATR/PARP1-IN-1 Inhibitor / Unkown
HY-144686 ATM Inhibitor-3 Inhibitor / Unkown
HY-169310 ATM Inhibitor-11 Inhibitor / Unkown
HY-172247 ATR-IN-31 Inhibitor / Unkown
HY-144687 ATM Inhibitor-4 Inhibitor / Unkown
HY-13902A Berzosertib hydrochloride Inhibitor 98.77% Unkown
HY-144685 ATM Inhibitor-2 Inhibitor / Unkown
HY-147567 ATR-IN-15 Inhibitor / Unkown
HY-174989 ATM-IN-2 Inhibitor / Unkown
HY-149291 ATM Inhibitor-7 Inhibitor / Unkown
HY-141478 Antitumor agent-28 Inhibitor / Unkown
HY-151915 ATR-IN-20 Inhibitor / Unkown
HY-185575 ATM ligand-1 Ligand / Unkown
HY-N18301 Americanin A Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atm NCBI NCBI:472