Ulk1 - unc-51 like autophagy activating kinase 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 360827

About Ulk1

Primary_assembly 12: 45,851,710-45,877,966 forward strand.mRatBN7.2:CM026985.1

This gene has 2 transcripts (splice variants), 202 orthologues, 2 paralogues and is associated with 3 phenotypes. Biased expression in Heart (RPKM 81.8), Adrenal (RPKM 77.1) and 9 other tissues.

Summary

Predicted to enable several functions, including HSP90 protein binding activity; enzyme binding activity; and identical protein binding activity. Involved in neuron projection regeneration and positive regulation of autophagosome assembly. Located in axon. Used to study mucositis. Orthologous to human ULK1 (unc-51 like Autophagy activating kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ulk1 Products (1)

mRNA Protein Name
NM_001108341.1 NP_001101811.1 serine/threonine-protein kinase ULK1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
18007665 RGD
involved in neuron projection regeneration IMP
IMP: Inferred from mutant phenotype
18007665 RGD
involved in positive regulation of autophagosome assembly IMP
IMP: Inferred from mutant phenotype
23448468 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
25040536 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ulk1 Protein Structure

STKc_ULK1

STKc_ULK1: cd14202 (12 - 278)

DUF3543

DUF3543: cl13493 (843 - 1050)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1057 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase ULK1

  • unc-51-like kinase 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-160699 DCC-3116 Inhibitor 99.84% Phase 2

Pre-clinical Phase

Bioactive Molecules (28)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16966 SBI-0206965 Inhibitor 99.92% Unkown
HY-13018 MRT67307 Inhibitor 99.56% Unkown
HY-100006 MRT68921 Inhibitor 98.09% Unkown
HY-114490 ULK-101 Inhibitor 99.91% Unkown
HY-100006A MRT68921 dihydrochloride Inhibitor 99.67% Unkown
HY-124729 BL-918 Activator 99.72% Unkown
HY-101923B LYN-1604 dihydrochloride Activator 99.55% Unkown
HY-101923 LYN-1604 Activator 99.47% Unkown
HY-137742 SBP-7455 Inhibitor 98.01% Unkown
HY-137506 XST-14 Inhibitor 99.26% Unkown
HY-148061 DB1113 99.86% Unkown
HY-179089 SBP-1750 Inhibitor 98.05% Unkown
HY-148063 DB0614 96.07% Unkown
HY-186224 GW296115 Inhibitor / Unkown
HY-101923A LYN-1604 hydrochloride Activator / Unkown
HY-13018A MRT67307 hydrochloride Inhibitor / Unkown
HY-162100 MR-2088 Inhibitor 99.50% Unkown
HY-143466 ULK1-IN-2 Inhibitor 98.34% Unkown
HY-161850 ULK1-IN-3 Inhibitor / Unkown
HY-100006B MRT68921 hydrochloride Inhibitor / Unkown
HY-181815 SBP-5147 Inhibitor / Unkown
HY-181699 ULK1-IN-5 Inhibitor / Unkown
HY-181062 VWK147 Inhibitor / Unkown
HY-181742 ULK1/2-IN-1 Inhibitor / Unkown
HY-125199 ULK-100 Inhibitor / Unkown
HY-158408 NZ-66 / Unkown
HY-184326 DRAK2-IN-2 Inhibitor / Unkown
HY-117413 SR-17398 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ulk1 NCBI NCBI:8408