KLRC1 - killer cell lectin like receptor C1 Gene

Also Known as NKG2; NKG2A; CD159A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3821

About KLRC1

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,442,264-10,454,685 (from NCBI)

This gene has 7 transcripts (splice variants), 676 orthologues and 23 paralogues. Broad expression in spleen (RPKM 1.5), endometrium (RPKM 1.3) and 21 other tissues.

Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]

KLRC1 Products (5)

mRNA	Protein	Name
NM_001304448.1	NP_001291377.1	NKG2-A/NKG2-B type II integral membrane protein isoform C
NM_002259.5	NP_002250.2	NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-A
NM_007328.4	NP_015567.2	NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-B
NM_213657.3	NP_998822.2	NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-B
NM_213658.3	NP_998823.2	NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables HLA-E specific inhibitory MHC class Ib receptor activity	IDA IDA: Inferred from direct assay	9486650	GOA
enables MHC class I protein complex binding	IPI IPI: Inferred from physical interaction	18448674	GOA
enables inhibitory MHC class Ib receptor activity	IDA IDA: Inferred from direct assay	37264229	GOA
NOT enables protein antigen binding	IDA IDA: Inferred from direct assay	18448674	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9485206	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in CD8-positive, gamma-delta intraepithelial T cell differentiation	IDA IDA: Inferred from direct assay	18064301	GOA
involved in natural killer cell inhibitory signaling pathway	IDA IDA: Inferred from direct assay	9485206	GOA
involved in negative regulation of T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	9485206	GOA
involved in negative regulation of natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	9485206	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	9485206	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	18448674	GOA
part of receptor complex	IPI IPI: Inferred from physical interaction	18448674	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLRC1 Protein Structure

Lectin_C

0
100
200
233 a.a.

Protein Preferred Names	Protein Names
NKG2-A/NKG2-B type II integral membrane protein	C-lectin type II protein

KLRC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KLRC1	P26715	CD151	Homo sapiens	P48509	Validated Y2H	32296183
Intra	KLRC1	P26715	TTMP	Homo sapiens	Q5BVD1	Validated Y2H	32296183
Intra	KLRC1	P26715	TMEM182	Homo sapiens	Q6ZP80	Validated Y2H	32296183
Intra	KLRC1	P26715	LSMEM2	Homo sapiens	Q8N112	Validated Y2H	32296183
Intra	KLRC1	P26715	CYB561A3	Homo sapiens	Q8NBI2	Validated Y2H	32296183
Intra	KLRC1	P26715	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	KLRC1	P26715	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	KLRC1	P26715	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	KLRC1	P26715	ERMP1	Homo sapiens	Q7Z2K6	Validated Y2H	32296183
Intra	KLRC1	P26715	TMPPE	Homo sapiens	Q6ZT21	Validated Y2H	32296183
Intra	KLRC1	P26715	CLEC2D	Homo sapiens	Q9UHP7-3	Complementation	32296183
Intra	KLRC1	P26715	CLEC2D	Homo sapiens	Q9UHP7-3	Validated Y2H	32296183
Intra	KLRC1	P26715	CLEC7A	Homo sapiens	Q9BXN2-6	Validated Y2H	32296183
Intra	KLRC1	P26715	CTXN3	Homo sapiens	Q4LDR2	Validated Y2H	32296183
Intra	KLRC1	P26715	MS4A13	Homo sapiens	Q5J8X5	Validated Y2H	32296183
Intra	KLRC1	P26715	PLP1	Homo sapiens	P60201-2	Validated Y2H	32296183
Intra	KLRC1	P26715	TSPO2	Homo sapiens	Q5TGU0	Validated Y2H	32296183
Intra	KLRC1	P26715	BRICD5	Homo sapiens	Q6PL45-2	Validated Y2H	32296183
Intra	KLRC1	P26715	GPR61	Homo sapiens	Q9BZJ8	Validated Y2H	32296183
Intra	KLRC1	P26715	GJB4	Homo sapiens	Q9NTQ9	Validated Y2H	32296183
Intra	KLRC1	P26715	CGRRF1	Homo sapiens	Q99675	Validated Y2H	32296183
Intra	KLRC1	P26715	PMP22	Homo sapiens	Q01453	Validated Y2H	25416956
Intra	KLRC1	P26715	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
Intra	KLRC1	P26715	PMP22	Homo sapiens	Q01453	Y2H Array	25416956
Intra	KLRC1	P26715	PMP22	Homo sapiens	Q01453	Y2H Prey Pooling	25416956
Intra	KLRC1	P26715	ITM2B	Homo sapiens	Q9Y287	Y2H Array	32814053
Intra	KLRC1	P26715	ITM2B	Homo sapiens	Q9Y287	Validated Y2H	32814053
Intra	KLRC1	P26715	ITM2B	Homo sapiens	Q9Y287	Y2H Pooling	32814053
Intra	KLRC1	P26715	DLST	Homo sapiens	P36957	Validated Y2H	32814053
Intra	KLRC1	P26715	DLST	Homo sapiens	P36957	Y2H Array	32814053
Intra	KLRC1	P26715	DLST	Homo sapiens	P36957	Y2H Pooling	32814053
Intra	KLRC1	P26715	ATP6V0B	Homo sapiens	Q99437	Validated Y2H	32296183
Intra	KLRC1	P26715	GJB2	Homo sapiens	P29033	Validated Y2H	32296183
Intra	KLRC1	P26715	EMP3	Homo sapiens	P54852	Validated Y2H	32296183
Intra	KLRC1	P26715	EMP3	Homo sapiens	P54852	Complementation	32296183
Intra	KLRC1	P26715	NKG7	Homo sapiens	Q16617	Validated Y2H	32296183
Intra	KLRC1	P26715	TMEM54	Homo sapiens	Q969K7	Validated Y2H	32296183
Intra	KLRC1	P26715	MAL	Homo sapiens	P21145	Validated Y2H	25416956
Intra	KLRC1	P26715	MAL	Homo sapiens	P21145	Y2H Array	25416956
Intra	KLRC1	P26715	MAL	Homo sapiens	P21145	Y2H Prey Pooling	25416956
Intra	KLRC1	P26715	EMP1	Homo sapiens	P54849	Validated Y2H	32296183
Intra	KLRC1	P26715	UNC93B1	Homo sapiens	Q9H1C4	Validated Y2H	32296183
Intra	KLRC1	P26715	CD82	Homo sapiens	P27701	Validated Y2H	32296183
Intra	KLRC1	P26715	ATP6V0C	Homo sapiens	P27449	Validated Y2H	32296183
Intra	KLRC1	P26715	VTI1B	Homo sapiens	Q9UEU0	Validated Y2H	32296183
Intra	KLRC1	P26715	MALL	Homo sapiens	Q13021	Validated Y2H	32296183
Intra	KLRC1	P26715	KLRG1	Homo sapiens	Q96E93	Validated Y2H	32296183
Intra	KLRC1	P26715	KLRD1	Homo sapiens	Q13241	BN-PAGE	32575403

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KLRC1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70551	NKG2A Protein, Human (HEK293, His)	P26715-1 (R100-L233)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70713	NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Flag)	P26715 (R100-L233)&Q13241-1 (S34-I179)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74691	NKG2A Protein, Human (Biotinylated, HEK293, His)	P26715-1 (P94-L233)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P77803	NKG2A-CD94 Heterodimer Protein, Human (HEK293, Fc-Flag)	P26715 (R100-L233)&Q13241-1 (S34-I179)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77804	NKG2A-CD94 Heterodimer Protein, Human (HEK293, mFc)	P26715 (R100-L233)&Q13241-1 (S34-I179)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77805	NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Avi)	P26715 (R100-L233)&Q13241-1 (S34-I179)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77806	NKG2A-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi)	P26715 (R100-L233)&Q13241-1 (S34-I179)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78182	NKG2A Protein, Human (Biotinylated, HEK293, His-Avi)	P26715-1 (R100-L233)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78497	NKG2A Protein, Human (HEK293, Fc)	P26715-1 (R100-L233)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78499	NKG2A Protein, Human (HEK293, His-Avi)	P26715-1 (R100-L233)	≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases	Alias
Nk Cell Deficiency
Human Cytomegalovirus Infection	Cytomegalovirus Infection Cytomegalovirus Infections
Bare Lymphocyte Syndrome, Type I	Hla Class I Deficiency Mhc Class I Deficiency Bls, Type I Bare Lymphocyte Syndrome Type I Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency Blsi Mhc Class 1 Deficiency Major Histocompatibility Complex Class 1 Deficiency Bare Lymphocyte Syndrome 1 BLS1 Bls I Bls Type I Bl-1 Bare Lymphocyte Syndrome Type 1 Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1 Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens Bls - [Bare Lymphocyte Syndrome] Nos
Bronchiectasis 1
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Parotid Gland Adenoid Cystic Carcinoma	Adenoid Cystic Carcinoma Of Parotid Gland
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07391	KLRC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19453	Klrc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25945	Klrc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KLRC1	MGD	MGI:1336161
Rattus norvegicus	KLRC1	RGD	RGD:2976
Others	KLRC1	NCBI