2. Gene
  3. KLRC1 - killer cell lectin like receptor C1 Gene

KLRC1 - killer cell lectin like receptor C1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NKG2; NKG2A; CD159A

Gene ID: 3821 | Gene type: protein coding

About KLRC1

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,442,264-10,454,685 (from NCBI)

This gene has 7 transcripts (splice variants), 676 orthologues and 23 paralogues. Broad expression in spleen (RPKM 1.5), endometrium (RPKM 1.3) and 21 other tissues.

Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]

KLRC1 Products(5)

mRNA Protein Name
NM_001304448.1 NP_001291377.1 NKG2-A/NKG2-B type II integral membrane protein isoform C
NM_002259.5 NP_002250.2 NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-A
NM_007328.4 NP_015567.2 NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-B
NM_213657.3 NP_998822.2 NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-B
NM_213658.3 NP_998823.2 NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-A

KLRC1 Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (137 - 230)

  • 0
  • 100
  • 200
  • 233 a.a.
Protein Preferred Names Protein Names

NKG2-A/NKG2-B type II integral membrane protein

C-lectin type II protein

Recombinant KLRC1 Proteins

Cat. No. Product Name Accession Purity
HY-P70551 NKG2A Protein, Human (HEK293, His) P26715 (R100-L233) ≥95%
HY-P70713 NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Flag) P26715 (R100-L233)&Q13241 (S34-I179) ≥95%
HY-P74691 NKG2A Protein, Human (Biotinylated, HEK293, His) P26715 (P94-L233) ≥95%
HY-P77803 NKG2A-CD94 Heterodimer Protein, Human (HEK293, Fc-Flag) P26715 (R100-L233)&Q13241 (S34-I179) ≥95%
HY-P77804 NKG2A-CD94 Heterodimer Protein, Human (HEK293, mFc) P26715 (R100-L233)&Q13241 (S34-I179) ≥95%
HY-P77805 NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Avi) P26715 (R100-L233)&Q13241 (S34-I179) ≥95%
HY-P77806 NKG2A-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) P26715 (R100-L233)&Q13241 (S34-I179) ≥95%
HY-P78182 NKG2A Protein, Human (Biotinylated, HEK293, His-Avi) P26715-1 (R100-L233) ≥95%
HY-P78497 NKG2A Protein, Human (HEK293, Fc) P26715 (R100-A219) ≥95%
HY-P78499 NKG2A Protein, Human (HEK293, His-Avi) P26715 (R100-L233) ≥95%

Related Diseases

Diseases Alias
Nk Cell Deficiency
Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections
Bare Lymphocyte Syndrome, Type I

Hla Class I Deficiency

Mhc Class I Deficiency

Bls, Type I

Bare Lymphocyte Syndrome Type I

Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency

Blsi

Mhc Class 1 Deficiency

Major Histocompatibility Complex Class 1 Deficiency

Bare Lymphocyte Syndrome 1

BLS1

Bls I

Bls Type I

Bl-1

Bare Lymphocyte Syndrome Type 1

Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1

Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens

Bls - [Bare Lymphocyte Syndrome] Nos
Bronchiectasis 1
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Parotid Gland Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Parotid Gland
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07391 KLRC1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KLRC1 MGD MGI:1336161
Rattus norvegicus KLRC1 RGD RGD:2976
Macaca fascicularis KLRC1 NCBI
Macaca mulatta KLRC1 NCBI
Others KLRC1 NCBI