COMT - catechol-O-methyltransferase Gene

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding
Gene ID: 445450

About COMT

Primary_assembly 26: 30,763,078-30,783,978 reverse strand.ROS_Cfam_1.0:CM025125.1

This gene has 3 transcripts (splice variants), 276 orthologues and 2 paralogues.

COMT Products (1)

mRNA Protein Name
NM_001004074.1 NP_001004074.1 catechol O-methyltransferase

COMT Protein Structure

YrrM

YrrM: cl28097 (48 - 240)

  • 0
  • 100
  • 200
  • 269 a.a.
Protein Preferred Names Protein Names

catechol O-methyltransferase

  • O-methyltransferase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1473A Serotonin Inhibitor 99.86% Unkown
HY-B1473 Serotonin hydrochloride Inhibitor 99.97% Unkown
HY-17406 Tolcapone Inhibitor 99.86% Yes
HY-14280 Entacapone Inhibitor 99.97% Yes
HY-14896 Opicapone Inhibitor 98.81% Yes
HY-100562 Flopropione Inhibitor 99.97% Unkown
HY-B1473R Serotonin hydrochloride (Standard) Inhibitor 99.28% Unkown
HY-14280R Entacapone (Standard) Inhibitor 99.24% Unkown
HY-17406R Tolcapone (Standard) Inhibitor / Unkown
HY-14280A Entacapone sodium salt Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-N0529 Rosmarinic acid Inhibitor 99.73% Phase 3
HY-106405 Nebicapone Inhibitor 99.89% Phase 2
HY-106842 Nitecapone Inhibitor 98.71% Phase 2
HY-19061 CGP 28014 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (30)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B1473AS Serotonin-d4 Inhibitor 99.61% Unkown
HY-N0522 (-)-Gallocatechin gallate Inhibitor 99.97% Unkown
HY-B1473S Serotonin-d4 hydrochloride Inhibitor 99.48% Unkown
HY-133068 5-Hydroxyferulic acid 99.43% Unkown
HY-125339 Ro 41-0960 Inhibitor 98.22% Unkown
HY-100959 3,5-Dinitrocatechol Inhibitor 99.72% Unkown
HY-W012264 3-O-Methyldopa monohydrate 99.16% Unkown
HY-151388 hMAO-B/MB-COMT-IN-1 Inhibitor 98.04% Unkown
HY-157719 S-Adenosylhomocysteine sulfoxide Inhibitor ≥95.0% Unkown
HY-128410 4-Phenyl-7,8-dihydroxycoumarin Inhibitor 99.35% Unkown
HY-17406S1 Tolcapone-d4 Inhibitor 99.13% Unkown
HY-121949 U-0521 Inhibitor 98.67% Unkown
HY-14280S Entacapone-d10 Inhibitor 98.6% Unkown
HY-120325 DHMPA Inhibitor / Unkown
HY-W704878 (Z)-Entacapone-d10-1 / Unkown
HY-17406S Tolcapone-d7 Inhibitor / Unkown
HY-139089 (Z)-Entacapone Inhibitor / Unkown
HY-100642S1 3-O-Methyltolcapone-d4 Inhibitor / Unkown
HY-133068A (E)-5-Hydroxyferulic acid / Unkown
HY-100642S 3-O-Methyltolcapone-d7 Inhibitor 99.0% Unkown
HY-169611 Serotonin maleate Inhibitor / Unkown
HY-B1473S2 Serotonin-13C,D4 / Unkown
HY-109119 Neluxicapone Inhibitor / Unkown
HY-162760 COMT-IN-1 Inhibitor / Unkown
HY-151390 hMAO-B/MB-COMT-IN-2 Inhibitor / Unkown
HY-168154 COMT-IN-2 Inhibitor / Unkown
HY-156069 Methylspinazarin Inhibitor / Unkown
HY-100642 3-O-Methyltolcapone Inhibitor 99.95% Unkown
HY-119224 BIA 3-335 Inhibitor / Unkown
HY-126194 Tolcapone 3-β-D-glucuronide Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens COMT NCBI NCBI:1312