Rad51 - RAD51 recombinase Gene

Also Known as RGD1563603

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 499870

About Rad51

Primary_assembly 3: 106,100,381-106,125,035 forward strand.mRatBN7.2:CM026976.1

This gene has 3 transcripts (splice variants), 220 orthologues, 5 paralogues and is associated with 20 phenotypes. Biased expression in Thymus (RPKM 112.8), Spleen (RPKM 6.) and 9 other tissues.

Summary

Predicted to enable several functions, including ATP binding activity; DNA binding activity; and catalytic activity, acting on DNA. Involved in several processes, including cellular response to cisplatin; cellular response to gamma radiation; and response to X-ray. Located in nucleus. Used to study cardiomyopathy and hypertension. Biomarker of pancreatic Cancer. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group R; breast cancer; congenital mirror movement disorder; and ovarian Cancer. Orthologous to human RAD51 (RAD51 recombinase). [provided by Alliance of Genome Resources, Apr 2022]

Rad51 Products (1)

mRNA Protein Name
NM_001109204.1 NP_001102674.1 DNA repair protein RAD51 homolog 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to cisplatin IEP
IEP: Inferred from expression pattern
14755242 RGD
involved in cellular response to gamma radiation IEP
IEP: Inferred from expression pattern
9885240 RGD
involved in double-strand break repair via homologous recombination IEP
IEP: Inferred from expression pattern
14755242 RGD
involved in meiosis I IEP
IEP: Inferred from expression pattern
25142975 RGD
involved in response to X-ray IEP
IEP: Inferred from expression pattern
17148264 RGD
involved in response to glucoside IEP
IEP: Inferred from expression pattern
9885240 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
23969067 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
24243707 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11754170 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rad51 Protein Structure

recomb_RAD51

recomb_RAD51: TIGR02239 (24 - 338)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
Protein Preferred Names Protein Names

DNA repair protein RAD51 homolog 1

  • RAD51 homolog

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-19793 RS-1 Activator 99.77% Phase 2
HY-111887 Emzadirib Inhibitor 99.32% Phase 2
HY-10206 Amuvatinib Inhibitor 99.40% Phase 2

Pre-clinical Phase

Bioactive Molecules (40)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D0086 DIDS sodium salt Inhibitor 99.13% Unkown
HY-101462 RAD51 Inhibitor B02 Inhibitor 99.89% Unkown
HY-15317 RI-1 Inhibitor 99.83% Unkown
HY-103710 IBR2 Inhibitor 98.24% Unkown
HY-150147 CAM833 Inhibitor 99.83% Unkown
HY-126020 Bractoppin Inhibitor 99.90% Unkown
HY-N3980 Guaiol 99.67% Unkown
HY-N7271 Solanidine Inhibitor 99.90% Unkown
HY-163944 LL-K12-18 Modulator 98.42% Unkown
HY-16904 RI-2 Inhibitor 99.90% Unkown
HY-148183 Homologous recombination-IN-1 Inhibitor 98.65% Unkown
HY-126972A RI(dl)-2 TFA Inhibitor 98.8% Unkown
HY-122705 RAD51-IN-1 Inhibitor 99.18% Unkown
HY-143736 RAD51-IN-5 Inhibitor 98.87% Unkown
HY-136604 RAD51-IN-3 Inhibitor 99.60% Unkown
HY-176549 (Rac)-IBR120 Inhibitor 99.65% Unkown
HY-10206A Amuvatinib hydrochloride Inhibitor / Unkown
HY-143735 RAD51-IN-4 Inhibitor / Unkown
HY-143741 RAD51-IN-7 Inhibitor / Unkown
HY-143737 RAD51-IN-6 Inhibitor / Unkown
HY-178022 HDAC6-IN-63 Inhibitor / Unkown
HY-181694 SeSA-HCPT Inhibitor / Unkown
HY-169213 LN-439A Inhibitor / Unkown
HY-181651 SZU305 Degrader / Unkown
HY-178021 HDAC1-IN-11 Inhibitor / Unkown
HY-173345 BRCA2-RAD51-IN-2 Inhibitor / Unkown
HY-103710A (R)-IBR2 Control / Unkown
HY-170907 HDAC-IN-85 Inducer / Unkown
HY-126972 RI(dl)-2 Inhibitor / Unkown
HY-122583 D-G23 Inhibitor / Unkown
HY-121693 DIDS Inhibitor / Unkown
HY-P10516 BRC4 peptide / Unkown
HY-187096 ERα/RAD51 degrader 1 Degrader / Unkown
HY-150958 RAD51-IN-8 / Unkown
HY-N7271R Solanidine (Standard) Inhibitor / Unkown
HY-115533 LBL1 Inhibitor / Unkown
HY-169622 RAD51-IN-9 Inhibitor / Unkown
HY-162104 BRCA2-RAD51-IN-1 Inhibitor / Unkown
HY-172252 CSN5-IN-2 Inhibitor / Unkown
HY-181561 BRCA2-RAD51-IN-3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rad51 NCBI NCBI:5888