Pten - phosphatase and tensin homolog Gene

Also Known as Mmac; TEP1; MMAC1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 50557

About Pten

Primary_assembly 1: 230,630,338-230,696,838 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 150 orthologues, 5 paralogues and is associated with 162 phenotypes. Biased expression in Adrenal (RPKM 635.2), Lung (RPKM 588.6) and 9 other tissues.

Summary

Enables several functions, including PDZ domain binding activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; dephosphorylation; and negative regulation of transport. Located in several cellular components, including dendritic spine; mitochondrion; and postsynaptic membrane. Is active in postsynaptic cytosol. Used to study portal hypertension and substance-related disorder. Biomarker of several diseases, including acute myocardial infarction; fatty liver disease; glucose metabolism disease (multiple); retinal disease (multiple); and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast Cancer (multiple); gastrointestinal system Cancer (multiple); nervous system Cancer (multiple); and reproductive organ Cancer (multiple). Orthologous to human PTEN (Phosphatase and tensin homolog). [provided by Alliance of Genome Resources, Apr 2022]

Pten Products (1)

mRNA Protein Name
NM_031606.2 NP_113794.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
20628354 RGD
enables ionotropic glutamate receptor binding IDA
IDA: Inferred from direct assay
15102920 RGD
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IDA
IDA: Inferred from direct assay
17324556 RGD
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IMP
IMP: Inferred from mutant phenotype
20628354 RGD
enables platelet-derived growth factor receptor binding IDA
IDA: Inferred from direct assay
14718524 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16474401 RGD
enables protein tyrosine kinase binding IDA
IDA: Inferred from direct assay
22609523 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to ethanol IDA
IDA: Inferred from direct assay
12700235 RGD
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
12700235 RGD
involved in cellular response to insulin-like growth factor stimulus IDA
IDA: Inferred from direct assay
12700235 RGD
involved in cellular response to leptin stimulus IMP
IMP: Inferred from mutant phenotype
24103758 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
10662831 RGD
involved in cellular response to sorbitol IEP
IEP: Inferred from expression pattern
16807353 RGD
involved in inositol phosphate catabolic process IDA
IDA: Inferred from direct assay
18056380 RGD
involved in long-term synaptic depression IMP
IMP: Inferred from mutant phenotype
20628354 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
15317872 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
30783439 RGD
involved in negative regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
30783439 RGD
involved in negative regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
30783439 RGD
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
14656929 RGD
involved in negative regulation of defense response to bacterium IMP
IMP: Inferred from mutant phenotype
18056380 RGD
involved in negative regulation of dendrite extension IMP
IMP: Inferred from mutant phenotype
23028614 RGD
involved in negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
28008308 RGD
involved in negative regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
18056380 RGD
involved in negative regulation of potassium ion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
24103758 RGD
involved in negative regulation of signaling receptor activity IMP
IMP: Inferred from mutant phenotype
24044036 RGD
involved in neuron projection development IDA
IDA: Inferred from direct assay
14990793 RGD
involved in phosphatidylinositol dephosphorylation IDA
IDA: Inferred from direct assay
17324556 RGD
involved in phosphatidylinositol dephosphorylation IMP
IMP: Inferred from mutant phenotype
20628354 RGD
involved in platelet-derived growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
14718524 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16502258 RGD
involved in positive regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
22609523 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20578043 RGD
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
30783439 RGD
involved in positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
10662831 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
30783439 RGD
involved in protein dephosphorylation IMP
IMP: Inferred from mutant phenotype
22609523 RGD
involved in regulation of Fc receptor mediated stimulatory signaling pathway IMP
IMP: Inferred from mutant phenotype
18056380 RGD
involved in response to ATP IEP
IEP: Inferred from expression pattern
17132626 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
23812090 RGD
involved in response to arsenic-containing substance IEP
IEP: Inferred from expression pattern
14713550 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
15482376 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
12939597 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
16804083 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
17166883 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18095365 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16188065 RGD
involved in response to zinc ion IEP
IEP: Inferred from expression pattern
18054565 RGD
Cellular Component GO Annotation Evidence References Source
located in dendritic spine IDA
IDA: Inferred from direct assay
20628354 RGD
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
26780512 RGD
is active in postsynaptic cytosol IMP
IMP: Inferred from mutant phenotype
26780512 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
20628354 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pten Protein Structure

PTP_PTEN

PTP_PTEN: cd14509 (23 - 180)

PTEN_C2

PTEN_C2: pfam10409 (187 - 348)

  • 0
  • 100
  • 200
  • 300
  • 403 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

  • mutated in multiple advanced cancers 1

  • phosphatase and tensin homolog deleted on chromosome ten

  • protein tyrosine phosphatase and tensin-like protein

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-128932 Cefminox sodium 99.83% Unkown

Pre-clinical Phase

Bioactive Molecules (29)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18234A Leupeptin hemisulfate Inhibitor 99.39% Yes
HY-13074 VO-Ohpic trihydrate Inhibitor / Unkown
HY-128693 BpV(HOpic) Inhibitor ≥98.0% Unkown
HY-15842 SF1670 Inhibitor 98.57% Unkown
HY-N1435 Oroxin B Activator 99.39% Unkown
HY-N0103 Sophocarpine Activator 99.85% Unkown
HY-N1441 Afzelin 99.62% Unkown
HY-160093 SQLE-IN-1 Inducer 99.21% Unkown
HY-136065 bpV(phen) Inhibitor 98.0% Unkown
HY-N2116 Ginkgolic acid C17:1 Inhibitor 99.80% Unkown
HY-144707 AK-778-XXMU Agonist 99.96% Unkown
HY-122818 BpV(phen) trihydrate Inhibitor 98.0% Unkown
HY-106263B Tyroserleutide hydrochloride Activator 99.92% Unkown
HY-18764 BpV(pic) potassium hydrate Inhibitor 98.8% Unkown
HY-N2993 Polyporenic acid C Activator ≥99.0% Unkown
HY-170791 CIB-L43 Activator 99.71% Unkown
HY-18234C Leupeptin Ac-LL hydrochloride Inhibitor 95.0% Unkown
HY-N11709 Theasaponin E1 Activator 99.08% Unkown
HY-N8884 Coelonin Inhibitor 98.0% Unkown
HY-N7325 Valerosidate Inducer 96% Unkown
HY-18234 Leupeptin Inhibitor / Unkown
HY-178360 NP1192 / Unkown
HY-181097 EGFR-IN-192 Modulator / Unkown
HY-179498 ROCK2-IN-13 Activator / Unkown
HY-110067 VO-OHPic Inhibitor / Unkown
HY-167843 Alborixin / Unkown
HY-18234B Leupeptin Ac-LL Inhibitor / Unkown
HY-131549A bpV(bipy) hydrate Inhibitor / Unkown
HY-183478 Leupeptin hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pten NCBI NCBI:5728