Gsdmd - gasdermin D Gene

Also Known as DF5L; M2-4; Dfna5l; GsdmD-1; Gsdmdc1; 1810036L03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 69146

Summary

Enables phospholipid binding activity and wide pore channel activity. Involved in several processes, including defense response to bacterium; positive regulation of interleukin-1 beta production; and protein-containing complex assembly. Acts upstream of or within cellular response to extracellular stimulus. Located in cytosol; extracellular space; and plasma membrane. Part of NLRP3 inflammasome complex. Is expressed in several structures, including gut; liver; lung; metanephros; and spleen. Orthologous to human GSDMD (gasdermin D). [provided by Alliance of Genome Resources, Apr 2022]

Gsdmd Products (1)

mRNA Protein Name
NM_026960.4 NP_081236.1 gasdermin-D

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cardiolipin binding IDA
IDA: Inferred from direct assay
27383986 MGI
enables phosphatidic acid binding IDA
IDA: Inferred from direct assay
27383986 MGI
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
27383986 MGI
enables phosphatidylinositol-4-phosphate binding IDA
IDA: Inferred from direct assay
27383986 MGI
enables phosphatidylserine binding IDA
IDA: Inferred from direct assay
27383986 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
37327784 MGI
enables wide pore channel activity IDA
IDA: Inferred from direct assay
27339137 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to stimulus IDA
IDA: Inferred from direct assay
10322635 MGI
involved in defense response to Gram-negative bacterium IDA
IDA: Inferred from direct assay
27383986 MGI
involved in defense response to Gram-negative bacterium IMP
IMP: Inferred from mutant phenotype
37988464 MGI
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
27383986 MGI
involved in pore complex assembly IDA
IDA: Inferred from direct assay
27383986 MGI
involved in positive regulation of inflammatory response IDA
IDA: Inferred from direct assay
27383986 MGI
involved in positive regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
26611636 MGI
involved in protein homooligomerization IDA
IDA: Inferred from direct assay
27383986 MGI
involved in protein secretion IDA
IDA: Inferred from direct assay
35705808 MGI
involved in pyroptotic cell death IDA
IDA: Inferred from direct assay
27339137 MGI
involved in pyroptotic inflammatory response IDA
IDA: Inferred from direct assay
26611636 MGI
involved in pyroptotic inflammatory response IMP
IMP: Inferred from mutant phenotype
37988464 MGI
Cellular Component GO Annotation Evidence References Source
part of NLRP3 inflammasome complex IDA
IDA: Inferred from direct assay
26611636 MGI
located in cytosol IDA
IDA: Inferred from direct assay
27383986 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
27383986 MGI
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
37001519 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
27339137 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
27339137 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gasdermin-D

  • gasdermin domain containing 1

  • gasdermin domain-containing protein 1

  • gasderminD-1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0240 Disulfiram 99.77% Unkown
HY-B0240R Disulfiram (Standard) 99.54% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-19309 ABT-546 hydrochloride / Phase 1

Pre-clinical Phase

Bioactive Molecules (33)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13453 BAY 11-7082 99.98% Unkown
HY-127019 Nigericin 99.64% Unkown
HY-100381 Nigericin sodium salt 99.60% Unkown
HY-100573 Necrosulfonamide 98.61% Unkown
HY-111674 LDC7559 Inhibitor 99.47% Unkown
HY-171006 IRF1-IN-1 Inhibitor 99.72% Unkown
HY-N0816 Polyphyllin VI 98.49% Unkown
HY-N2414 Periplogenin ≥99.70% Unkown
HY-111675 Ac-FLTD-CMK Inhibitor 99.18% Unkown
HY-171007 IRF1-IN-2 99.83% Unkown
HY-N0218 Benzoylmesaconine Inhibitor 99.56% Unkown
HY-18711A SCR-1481B1 Inhibitor 99.95% Unkown
HY-152670 JC2-11 Inhibitor 98.03% Unkown
HY-N7400 Phaseoloidin 99.92% Unkown
HY-RS05857 GSDMD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-156374 D359-0396 Inhibitor 99.98% Unkown
HY-161727 P2Y14R antagonist 1 98.76% Unkown
HY-100573A (E/Z)-Necrosulfonamide 98.03% Unkown
HY-100573S Necrosulfonamide-d4 99.65% Unkown
HY-130480 Fructose-arginine Inhibitor 98.32% Unkown
HY-173234 GI-Y2 Inhibitor / Unkown
HY-P11603 SK56 Inhibitor / Unkown
HY-RS16519 Gsdmd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-135283 ABT-546 / Unkown
HY-161332 Antitumor agent-143 / Unkown
HY-172788 NLRP3-IN-78 Inhibitor / Unkown
HY-175640 Troponin-IN-1 Inhibitor / Unkown
HY-179348 DPP9-IN-2 / Unkown
HY-180830 NLRP3-IN-86 Inhibitor / Unkown
HY-181168 Lb54 / Unkown
HY-182066 Photosensitizer-9 Activator / Unkown
HY-185207 CQ80 Inducer / Unkown
HY-RS22950 Gsdmd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gsdmd NCBI NCBI:79792