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Cat. No.: HY-16742C

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Gepotidacin hydrochloride

(Synonyms: GSK2140944 hydrochloride)

12 Cited Publications

Customer Review

Based on 12 publication(s) in Google Scholar

Gepotidacin hydrochloride is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor.

For research use only. We do not sell to patients.

CAS No.: 1075235-46-9
Formula: C₂₄H₂₉ClN₆O₃
Molecular Weight:484.98

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Gepotidacin hydrochloride Chemical Structure

CAS No.: 1075235-46-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Gepotidacin hydrochloride is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor.

All Antibiotic Isoforms :

All Topoisomerase Isoforms :

Chemical Information

CAS No. 1075235-46-9
Molecular Weight 484.98
Formula C₂₄H₂₉ClN₆O₃
SMILES

O=C(C=NC(C=C1)=C23)N3[C@H](CN4CCC(NCC5=CC(CCCO6)=C6C=N5)CC4)CN2C1=O.Cl
Synonyms

GSK2140944 hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (12)

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Nat Microbiol

Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains. [Abstract]

2023 Mar;8(3):410-423. PMID: 36759752
Cell Chem Biol

Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation. [Abstract]

2019 Sep 19;26(9):1274-1282.e4. PMID: 31279606

Gepotidacin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Chem Biol. 2019 Sep 19;26(9):1274-1282.e4. [Abstract]

Cross-Resistance of EN-7^R Strains with Other Gyrase Inhibitors
No observed cross-resistance between EN-7 and other gyrase-targeting antibiotics, ciprofloxacin and novobiocin; however, there is some cross-resistance to the NBTI Gepotidacin.
PLoS Biol

Rational design of balanced dual-targeting antibiotics with limited resistance. [Abstract]

2020 Oct 5;18(10):e3000819. PMID: 33017402
Antibiotics (Basel)

Antibacterial Activity of the Novel Drug Gepotidacin against Stenotrophomonas maltophilia-An In Vitro and In Vivo Study. [Abstract]

2022 Feb 1;11(2):192. PMID: 35203795

Gepotidacin hydrochloride purchased from MedChemExpress. Usage Cited in: Antibiotics (Basel). 2022 Feb 1;11(2):192. [Abstract]

MIC (mg/L) distribution of N = 100 Stenotrophomonas maltophilia strains for Gepotidacin as found in broth microdilution after EUCAST.
ACS Infect Dis

Activities of the Novel Bacterial Topoisomerase Inhibitor OSUAB-0284 against the Biothreat Pathogen Bacillus anthracis and Its Type II Topoisomerases. [Abstract]

2026 Jan 9;12(1):363-375. PMID: 41430688

Gepotidacin hydrochloride purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2026 Jan 9;12(1):363-375. [Abstract]

Gepotidacin induced primarily single-stranded DNA breaks mediated by B. anthracis gyrase.
ACS Infect Dis

Role of DNA Double-Strand Break Formation in Gyrase Inhibitor-Mediated Killing of Nonreplicating Persistent Mycobacterium tuberculosis in Caseum. [Abstract]

2024 Oct 11;10(10):3631-3639. PMID: 39315541
Antimicrob Agents Chemother

Stepwise evolution and clonal enrichment of gepotidacin resistance in Neisseria gonorrhoeae. [Abstract]

2026 Apr;70(4):e0170625. PMID: 41810969

Gepotidacin hydrochloride purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2026 Apr;70(4):e0170625. [Abstract]

In vitro induction of Gepotidacin (18-24 h) resistance in N. gonorrhoeae ST8123 occurred. MZX-24-16 (ST8123 isolate with GyrA S91F/D95A and ParC E91G) was used.
Antimicrob Agents Chemother

Multidrug tolerance conferred by loss-of-function mutations in anti-sigma factor RshA of Mycobacterium abscessus. [Abstract]

2024 Dec 5;68(12):e0105124. PMID: 39470195
Microbiol Spectr

Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors Exhibit Bactericidal Activity against Planktonic and Biofilm Staphylococcus aureus In Vitro. [Abstract]

2022 Dec 21;10(6):e0205622. PMID: 36250857

Gepotidacin hydrochloride purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2022 Dec 21;10(6):e0205622. [Abstract]

Time-kill kinetics of the novel bacterial topoisomerase inhibitor (NBTI) compound Gepotidacin and comparator agents for S. aureus were assessed.Untreated time (T) of 0 h, 1.67 × 10⁶ CFU/mL; untreated T of 24 h, 3.66 × 10⁹ CFU/mL.
Vet Microbiol

Antibacterial activity of novel bacterial topoisomerase inhibitors against key veterinary pathogens. [Abstract]

2023 Sep:284:109840. PMID: 37531840
bioRxiv

2026 Feb 23.
University of Szeged

2019 Jan.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Farrell DJ, et al. In Vitro Activity of Gepotidacin (GSK2140944) against Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2017 Feb 23;61(3). [Content Brief]

[2]. Biedenbach DJ, et al. In Vitro Activity of Gepotidacin, a Novel Triazaacenaphthylene Bacterial Topoisomerase Inhibitor, against a Broad Spectrum of Bacterial Pathogens. Antimicrob Agents Chemother. 2016 Jan 4;60(3):1918-23. [Content Brief]

[3]. O'Riordan W, et al. Efficacy, Safety, and Tolerability of Gepotidacin (GSK2140944) in the Treatment of Patients with Suspected or Confirmed Gram-Positive Acute Bacterial Skin and Skin Structure Infections. Antimicrob Agents Chemother. 2017 May 24;61(6). [Content Brief]

[4]. So W, et al. Pharmacodynamic Profile of GSK2140944 against Methicillin-Resistant Staphylococcus aureus in a Murine Lung Infection Model. Antimicrob Agents Chemother. 2015 Aug;59(8):4956-61. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Gepotidacin hydrochloride

12 Cited Publications

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Biological Activity
- Description
Chemical Information
Publications (12)
Purity & Documentation
References

1/16
1/16

Gepotidacin hydrochloride purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2026 Jan 9;12(1):363-375. [Abstract]

Customer Validation
Gepotidacin induced primarily single-stranded DNA breaks mediated by B. anthracis gyrase.
1/16

Gepotidacin hydrochloride purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2026 Apr;70(4):e0170625. [Abstract]

Customer Validation
In vitro induction of Gepotidacin (18-24 h) resistance in N. gonorrhoeae ST8123 occurred. MZX-24-16 (ST8123 isolate with GyrA S91F/D95A and ParC E91G) was used.
1/16

Gepotidacin hydrochloride purchased from MedChemExpress. Usage Cited in: Antibiotics (Basel). 2022 Feb 1;11(2):192. [Abstract]

Customer Validation
MIC (mg/L) distribution of N = 100 Stenotrophomonas maltophilia strains for Gepotidacin as found in broth microdilution after EUCAST.
1/16

Gepotidacin hydrochloride purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2022 Dec 21;10(6):e0205622. [Abstract]

Customer Validation
Time-kill kinetics of the novel bacterial topoisomerase inhibitor (NBTI) compound Gepotidacin and comparator agents for S. aureus were assessed.Untreated time (T) of 0 h, 1.67 × 10⁶ CFU/mL; untreated T of 24 h, 3.66 × 10⁹ CFU/mL.
1/16

Gepotidacin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Chem Biol. 2019 Sep 19;26(9):1274-1282.e4. [Abstract]

Customer Validation
Cross-Resistance of EN-7^R Strains with Other Gyrase Inhibitors
No observed cross-resistance between EN-7 and other gyrase-targeting antibiotics, ciprofloxacin and novobiocin; however, there is some cross-resistance to the NBTI Gepotidacin.

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Gepotidacin hydrochloride

Publications Citing Use of MedChemExpress (MCE) Gepotidacin hydrochloride

All Antibiotic Isoforms

All Topoisomerase Isoforms

Biological Activity

Chemical Information

Publications (12)

Purity & Documentation

References

Calculators

Help & FAQs

Gepotidacin hydrochloride Related Classifications

HY-16742C Related Classifications