2. Anti-infection Cell Cycle/DNA Damage
  3. Antibiotic Bacterial Topoisomerase
  4. Gepotidacin hydrochloride

Gepotidacin hydrochloride  (Synonyms: GSK2140944 hydrochloride)

Cat. No.: HY-16742C
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Gepotidacin hydrochloride is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor.

For research use only. We do not sell to patients.

CAS No. : 1075235-46-9

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Gepotidacin hydrochloride Related Antibodies

Top Publications Citing Use of Products

    Gepotidacin hydrochloride purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2026 Apr;70(4):e0170625.

    In vitro induction of Gepotidacin (18-24 h) resistance in N. gonorrhoeae ST8123 occurred. MZX-24-16 (ST8123 isolate with GyrA S91F/D95A and ParC E91G) was used.

    Gepotidacin hydrochloride purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2026 Jan 9;12(1):363-375.  [Abstract]

    Gepotidacin induced primarily single-stranded DNA breaks mediated by B. anthracis gyrase.

    Gepotidacin hydrochloride purchased from MedChemExpress. Usage Cited in: Antibiotics (Basel). 2022 Feb 1;11(2):192.

    MIC (mg/L) distribution of N = 100 Stenotrophomonas maltophilia strains for Gepotidacin as found in broth microdilution after EUCAST.

    Gepotidacin hydrochloride purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2022 Dec 21;10(6):e0205622.  [Abstract]

    Time-kill kinetics of the novel bacterial topoisomerase inhibitor (NBTI) compound Gepotidacin and comparator agents for S. aureus were assessed.Untreated time (T) of 0 h, 1.67 × 106 CFU/mL; untreated T of 24 h, 3.66 × 109 CFU/mL.

    Gepotidacin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Chem Biol. 2019 Sep 19;26(9):1274-1282.e4.  [Abstract]

    Cross-Resistance of EN-7R Strains with Other Gyrase Inhibitors
    No observed cross-resistance between EN-7 and other gyrase-targeting antibiotics, ciprofloxacin and novobiocin; however, there is some cross-resistance to the NBTI Gepotidacin.

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    Topoisomerase Topo I Topo II DNA gyrase

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    Gepotidacin hydrochloride Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Gepotidacin1075235-46-9GSK2140944GSK 2140944GSK-2140944AntibioticBacterialTopoisomeraseInhibitorinhibitorinhibit

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