Actin
Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. Actin exists in three major isoforms, including α-, β-, and γ-actin. α-Actin isoform is predominantly expressed in muscle cells (e.g., α-skeletal, α-cardiac, α-vascular smooth), while β- and γ-actin are primarily found in nonmuscle cells (e.g., β-cytoplasmic, γ-cytoplasmic, γ-enteric smooth). In physiological conditions, actin can reversibly polymerize between its monomeric (G-actin) and filamentous (F-actin) forms. The ability of actin to reversibly assemble into filaments (F-actin) provides the foundation upon which many essential cellular functions rely, such as cell movement, cytokinesis, and maintenance of the cytoskeletal structure, which is closely associated with cancer metastasis.
Actin Isoform Specific Products
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Actin Related Products (9)
Related Products (9)
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Actin Isoform Comparison
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3-(4-Pyridyl)indole
0 ImagesSynonyms: Rockout; 3-(4-Pyridinyl)-1H-indole; Rho Kinase Inhibitor III, Rockout3-(4-Pyridyl)indole (Rockout; 3-(4-Pyridinyl)-1H-indole; Rho Kinase Inhibitor III, Rockout) is a Rho-kinase inhibitor (IC50 = 25 μM). 3-(4-Pyridyl)indole inhibits cell migration, membrane blebbing, and stress fiber and focal adhesion formation, and induces actin stress fiber disassembly. 3-(4-Pyridyl)indole promotes cell spreading and alters cell morphology and dynamics. 3-(4-Pyridyl)indole inhibits PRK2. 3-(4-Pyridyl)indole is used in wound healing research.
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β-actin-IN-1
0 ImagesCat. No.: HY-184235β-actin-IN-1 is a selective and covalent β-actin polymerization inhibitor. β-actin-IN-1 targets Cys272 of β-actin and shows selectivity over α-actin and γ-actin. β-actin-IN-1 inhibits β-actin polymerization and disrupts the actin cytoskeleton in cancer cells, leading to cell migration inhibition as well as cell death. β-actin-IN-1 can be used for the study of osteosarcoma.
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CK-571
0 ImagesCat. No.: HY-180792CAS No.: 1119536-89-8CK-571 is an allosteric inhibitor of smooth muscle myosin (Myosin)-2. CK-571 binds the SH1-relay cleft of the motor domain, traps the intermediate conformation of the recovery stroke and stabilizes the ATP-bound state, blocking ATP hydrolysis and F-actin (Actin) binding. CK-571 inhibits actin-activated ATPase activity of non-muscle, cardiac, and skeletal muscle myosin-2. CK-571 can be used in research related to asthma and chronic obstructive pulmonary disease (COPD).
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(-)-Maritoclax
0 ImagesCat. No.: HY-15613ACAS No.: 1010732-14-5Synonyms: (-)-Marinopyrrole A(-)-Maritoclax ((-)-Marinopyrrole A) is an actin-targeting cytotoxic and antibacterial agent. (-)-Maritoclax exhibits cytotoxicity against cancer cells. (-)-Maritoclax can be used in the research of methicillin-resistant Staphylococcus aureus infections and colon cancer.
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CI-959 free acid
0 ImagesCat. No.: HY-113886CAS No.: 104795-66-6CI-959 free acid is an orally active cell activation inhibitor. CI-959 free acid selectively suppresses inflammatory cell activation post-receptor signaling via inhibiting calcium influx and weak calmodulin antagonism, without targeting PLC, PKC or NADPH oxidase. CI-959 free acid blocks lung allergic mediator release, anti-IgE bronchial contraction, neutrophil function, T-cell proliferation and DC marker expression while sparing monocytes. CI-959 free acid provides gastric cytoprotection by inhibiting leukocyte adhesion and suppresses tumor motility through F-actin reduction. CI-959 free acid can be used for research on allergies, inflammation, autoimmune diseases, gastric injury, and tumor metastasis .
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CI-959
0 ImagesCat. No.: HY-19108CAS No.: 104795-68-8CI-959 is an orally active cell activation inhibitor. CI-959 selectively suppresses inflammatory cell activation post-receptor signaling via inhibiting calcium influx and weak calmodulin antagonism, without targeting PLC, PKC or NADPH oxidase. CI-959 blocks lung allergic mediator release, anti-IgE bronchial contraction, neutrophil function, T-cell proliferation and DC marker expression while sparing monocytes. CI-959 provides gastric cytoprotection by inhibiting leukocyte adhesion and suppresses tumor motility through F-actin reduction. CI-959 can be used for research on allergies, inflammation, autoimmune diseases, gastric injury, and tumor metastasis .
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A2P5P
0 ImagesA2P5P (2',5'-ADP) is a P2Y1 purinergic receptor antagonist and ribonuclease inhibitor. A2P5P selectively blocks Adenosine 5'-diphosphate (ADP) (HY-W010918)-induced P2Y1-mediated phospholipase C activation and intracellular Ca2+ mobilization, is selective for P2Y2/P2Y4 with no significant effect on P2Y11, thereby inhibiting platelet shape change, aggregation, actin (Actin) polymerization, early αIIbβ3 activation, granule centralization, filopodia formation, and serotonin secretion, without affecting Thrombin (MW 37kDa) (HY-114164)-induced aggregation. A2P5P also binds to the catalytic site of RNase A (HY-129046), EDN, and ECP, inhibiting ribonucleolytic activity through water-mediated hydrogen bonds and transglycosidic/ribose conformations, stabilizing the inactive catalytic histidine conformation. A2P5P can be used for research on platelet function and ribonuclease-related studies.
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Antifungal agent 183
0 ImagesCat. No.: HY-189456Antifungal agent 183 is a Myosin I inhibitor (Kd = 0.37 μM) that binds to the conserved phenamacril-binding pocket in the motor domain of Botrytis cinerea myosin I, inhibits Actin-dependent ATPase activity, and blocks the ATPase cycle, thereby disrupting hyphal tip morphogenesis and inhibiting hyphal and colony growth. Antifungal agent 183 can be used for research on gray mold.
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Troponin I (104-115)
0 ImagesCat. No.: HY-P2142CAS No.: 98353-69-6Troponin I (104-115) is a polypeptide derived from Troponin I. Troponin I is an inhibitor of Acto-S1-TM ATPase, with an IC50 of 2.25 μM against skeletal muscle Acto-S1-TM ATP enzyme. Troponin I is used in research on muscle contraction-relaxation and restrictive cardiomyopathy.
