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Cat. No.: HY-136881

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CH0076989

CH0076989 is a specific CCR3 agonist. CH0076989 activates eosinophils and transfectants expressing both wild-type CCR3 and a CCR1:CCR3 chimaeric receptor lacking the CCR3 amino-terminus. CH0076989 has a direct interaction with the transmembrane helices of CCR3, supported by the complete loss of its activity due to mutations of the residues Y41, Y113 and E287. CH0076989 can be used for the study of inflammation and allergic diseases (such as asthma).

For research use only. We do not sell to patients.

CAS No.: 954371-52-9
Formula: C₂₄H₂₂Br₂N₂O₂
Molecular Weight:530.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CH0076989 Chemical Structure

CAS No.: 954371-52-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All CCR Isoforms :

In Vitro

CH0076989 (0.01-10 μM, 4 min) induces eosinophil shape change in a dose dependent manner^[1].
CH0076989 (0.0001-10 μM, 5 h) elicits chemotaxis in CCR3-transfected L1.2 cells with an optimal concentration of 1 μM, but has no effect on CCR1-transfected cells^[1].
CH0076989 (10 μM, 20 min) induces CCR3 internalization in CCR3-transfected L1.2 cells, which is dose-dependently inhibited by cis-J-113863 (UCB35625) (HY-103360A)^[1].
CH0076989 (0.0001-10 μM, 5 h) induces chemotaxis in L1.2 cells transfected with the CCR1:CCR3 chimeric receptor (Chi-1)^[1].
CH0076989 (0.0001-10 μM, 5 h) fails to induce chemotaxis in L1.2 cells transfected with Y41A, Y113A, or E287Q mutant CCR3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 954371-52-9
Molecular Weight 530.25
Formula C₂₄H₂₂Br₂N₂O₂
SMILES

BrC1=CC(NC(CC2=C3C=COC3=CC=C2)=O)=CC=[N+]1CCCC4=CC=CC=C4.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wise EL, et al. Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation. J Biol Chem. 2007 Sep 21;282(38):27935-43. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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