MTX-23
Based on 1 publication(s) in Google Scholar
MTX-23 is a PROTAC degrader targeting androgen receptor splice variant 7 (AR-V7) and full-length androgen receptor (AR-FL), with DC50 values of 0.37 μM and 2 μM, respectively. MTX-23 binds to the DNA-binding domains of AR-V7 and AR-FL, recruits the VHL E3 ubiquitin ligase (E3 ubiquitin ligase) and induces their degradation. MTX-23 reduces the proliferation of prostate cancer cells, promotes their apoptosis (apoptosis), and also inhibits tumor growth in mouse models. MTX-23 can be used for the research of prostate cancer.
(Pink: AR-V7 Target protein ligand; Blue: VHL ligand (HY-112078); Black: linker).
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 2488296-74-6
- Formula: C43H53F2N7O7S2
- Molecular Weight:882.05
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Anti-Cancer Compound Library
HY-L025
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Transcription Factor-Targeted Library
HY-L090
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Anti-Prostate Cancer Compound Library
HY-L124
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Nuclear Receptor Compound Library
HY-L126
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PROTAC Library
HY-L151
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) MTX-23
MoreAll PROTACs Isoforms
More
Biological Activity
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AR-V7 0.37 μM (DC50) |
AR-FL 2 μM (DC50) |
MTX-23 degrades AR-V7 with a DC50 of 0.37 μmol/L and AR-FL with a DC50 of 2 μmol/L as measured by immunoblot analysis[1].
MTX-23 inhibits proliferation and increases apoptosis in androgen-responsive prostate cancer cells, with this antiproliferative effect dependent on the presence of AR-V7 and AR-FL[1].
MTX-23 inhibits proliferation in 12 human prostate cancer cell lines resistant to second-line antiandrogen therapies[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2488296-74-6
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Appearance Solid
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Molecular Weight 882.05
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Formula C43H53F2N7O7S2
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Color Off-white to light yellow
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SMILES
O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCCCNC(COC4=C(C5=CSC(N6CCOCC6)=N5)C=CC(F)=C4F)=O)=O
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Synonyms
PROTAC AR-V7 degrader-2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Nature
2026 Apr;652(8110):763-773. PMID: 41882358
Solvent & Solubility
DMSO : 100 mg/mL (113.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1337 mL | 5.6686 mL | 11.3372 mL | 28.3431 mL |
| 5 mM | 0.2267 mL | 1.1337 mL | 2.2674 mL | 5.6686 mL | |
| 10 mM | 0.1134 mL | 0.5669 mL | 1.1337 mL | 2.8343 mL | |
| 15 mM | 0.0756 mL | 0.3779 mL | 0.7558 mL | 1.8895 mL | |
| 20 mM | 0.0567 mL | 0.2834 mL | 0.5669 mL | 1.4172 mL | |
| 25 mM | 0.0453 mL | 0.2267 mL | 0.4535 mL | 1.1337 mL | |
| 30 mM | 0.0378 mL | 0.1890 mL | 0.3779 mL | 0.9448 mL | |
| 40 mM | 0.0283 mL | 0.1417 mL | 0.2834 mL | 0.7086 mL | |
| 50 mM | 0.0227 mL | 0.1134 mL | 0.2267 mL | 0.5669 mL | |
| 60 mM | 0.0189 mL | 0.0945 mL | 0.1890 mL | 0.4724 mL | |
| 80 mM | 0.0142 mL | 0.0709 mL | 0.1417 mL | 0.3543 mL | |
| 100 mM | 0.0113 mL | 0.0567 mL | 0.1134 mL | 0.2834 mL |
MTX-23 Related Classifications
HY-148771 Related Classifications
Powered by Bioz
- MTX-23
- 2488296-74-6
- PROTAC AR-V7 degrader-2
- MTX23
- MTX 23
- PROTACs
- Androgen Receptor
- Apoptosis
- AR-V7
- Androgen Receptor Full-Length
- Androgen Receptor Splice Variant-7
- prostate cancer cells
- mouse models
- Von Hippel-Lindau E3 ubiquitin ligase
- AR-FL
- androgen-responsive prostate cancer cells
- human prostate cancer cell lines
- castration-resistant prostate cancer
- Inhibitor
- inhibitor
- inhibit