HPK1-IN-56
HPK1-IN-56 (Compound A29) is a HPK1 inhibitor (IC50: 2.70 nM). HPK1-IN-56 inhibits downstream p-SLP76 (IC50: 8.1 nM in Jurkat T cells). HPK1-IN-56 induces the production of IL-2 in human PBMCs. HPK1-IN-56 has anticancer effect, enhances T-cell killing ability and the antitumor efficacy of anti-PD-1 antibody.
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- CAS No.: 2901054-39-3
- 화학식: C24H26N8O
- 분자량:442.52
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
All MAP4K Isoforms
More
Biological Activity
제품 설명
IC50 & Target
[1]|
HPK1 2.7 nM (IC50) |
MAP4K4 18.2 nM (IC50) |
MAP4K6 27.9 nM (IC50) |
MAP4K5 79.1 nM (IC50) |
GLK/MAP4K3 29.2 nM (IC50) |
MAP4K2 104.3 nM (IC50) |
Chemical Information
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CAS No. 2901054-39-3
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분자량 442.52
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화학식 C24H26N8O
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SMILES
COC1=C(NC2=NN=C3C(N)=CC(C4=C(C)C(N)=CN=C4)=CC3=N2)C=C5CN(C)CCC5=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Patient-Derived Xenograft (PDX)
Patient-derived xenograft (PDX) models are generated by engrafting primary human tumor tissue directly into immunodeficient mice, allowing in vivo propagation of patient tumor biology without initial in vitro adaptation. These models are used to preserve key histopathological and molecular characteristics of the original tumor and enable assessment of tumor growth dynamics and therapeutic response in a living organism. The biological readout is tumor engraftment and subsequent growth in the murine host, which reflects the ability of human tumor cells to survive, vascularize, and expand in an immunocompromised microenvironment.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HPK1-IN-56 Related Classifications
HY-172107 Related Classifications
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