HPK1-IN-56
HPK1-IN-56 (Compound A29) is a HPK1 inhibitor (IC50: 2.70 nM). HPK1-IN-56 inhibits downstream p-SLP76 (IC50: 8.1 nM in Jurkat T cells). HPK1-IN-56 induces the production of IL-2 in human PBMCs. HPK1-IN-56 has anticancer effect, enhances T-cell killing ability and the antitumor efficacy of anti-PD-1 antibody.
For research use only. We do not sell to patients.
- CAS No.: 2901054-39-3
- Formula: C24H26N8O
- Molecular Weight:442.52
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All MAP4K Isoforms
More
Biological Activity
|
HPK1 2.7 nM (IC50) |
MAP4K4 18.2 nM (IC50) |
MAP4K6 27.9 nM (IC50) |
MAP4K5 79.1 nM (IC50) |
GLK/MAP4K3 29.2 nM (IC50) |
MAP4K2 104.3 nM (IC50) |
Chemical Information
-
CAS No. 2901054-39-3
-
Molecular Weight 442.52
-
Formula C24H26N8O
-
SMILES
COC1=C(NC2=NN=C3C(N)=CC(C4=C(C)C(N)=CN=C4)=CC3=N2)C=C5CN(C)CCC5=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HPK1-IN-56 Related Classifications
HY-172107 Related Classifications
Powered by Bioz