HPK1-IN-57
HPK1-IN-57 (Compound 10c) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 value of 0.09 nM. HPK1-IN-57 inhibits the activity of HPK1 kinase, hindering the phosphorylation of the downstream adaptor protein SLP76 (IC50 is 33.74 nM) and effectively stimulating the secretion of the T cell activation marker IL-2 (EC50 is 84.24 nM). HPK1-IN-57 is promising for research of tumor immunotherapy.
For research use only. We do not sell to patients.
- Formula: C30H36F2N8O3
- Molecular Weight:594.66
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All MAP4K Isoforms
More
Biological Activity
Chemical Information
-
Molecular Weight 594.66
-
Formula C30H36F2N8O3
-
SMILES
O=C(N)C1=CN=C(NC2=CC=C(C(NC3CCC(F)(F)CC3)=O)C=C2)N=C1NC4=C(OC)C=C(N5CCN(C)CC5)C=C4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HPK1-IN-57 Related Classifications
HY-172594 Related Classifications
Powered by Bioz